IC 261
- CAS No.
- 186611-52-9
- Chemical Name:
- IC 261
- Synonyms
- CS-1551;IC261, >98%;SU-5607 IC 261;IC-261(SU-5607);IC261;SU5607;IC 261;SU 5607;IC261 - CAS 186611-52-9 - Calbiochem;3-(2,4,6-Ttrimethoxybenzylidene)indolin-2-one;(E)-3-(2,4,6-trimethoxybenzylidene)indolin-2-one;IC261,Inhibitor,Apoptosis,IC-261,inhibit,IC 261,Casein Kinase;1,3-Dihydro-3-[(2,4,6-triMethoxyphenyl)Methylene]-2H-indol-2-one, SU5607
- CBNumber:
- CB2503626
- Molecular Formula:
- C18H17NO4
- Molecular Weight:
- 311.335
- MOL File:
- 186611-52-9.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/9/4 16:42:00
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
WGK Germany | 3 |
HS Code | 2933.79.8500 |
IC 261 price More Price(4)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | I0658 | IC 261 ≥98% (HPLC) | 186611-52-9 | 5MG | ₹15544.7 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 400090 | IC261 - CAS 186611-52-9 - Calbiochem A cell-permeable, reversible, potent and selective inhibitor of casein kinase (CK1) that inhibits CK1δ (IC?? = 0.7-1.3 μM) and CK1ε (IC?? = 0.6-1.4 μM | 186611-52-9 | 5MG | ₹17860 | 2022-06-14 | Buy |
TCI Chemicals (India) | I1077 | IC 261 | 186611-52-9 | 10MG | ₹7300 | 2022-05-26 | Buy |
TCI Chemicals (India) | I1077 | IC 261 | 186611-52-9 | 50MG | ₹14200 | 2022-05-26 | Buy |
IC 261 Chemical Properties,Uses,Production
General Description
A cell-permeable, reversible, potent and selective inhibitor of Casein Kinase (CK1) that inhibits the CK1δ (IC50 = 0.7-1.3 μM) and CK1ε (IC50 = 0.6-1.4 μM) isozymes. Also inhibits CK1α1 at much higher concentrations (IC50 = 11-21 μM). The inhibition is competitive with respect to ATP. Has only a trivial effect on p34cdc2 and p55fyn (IC50s >100 μM). Blocks the phosphorylation of p53 by CK1δ and CK1ε, thereby modulating p53′s effect on the cell cycle. At low micromolar concentrations, IC261 inhibits cytokinesis causing a transient mitotic arrest.
Biochem/physiol Actions
Cell permeable: yes
IC 261 Preparation Products And Raw materials
Global( 89)Suppliers
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32835 | 60 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29820 | 58 | Inquiry |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
Aladdin Scientific | +1-+1(833)-552-7181 | United States | 57511 | 58 | Inquiry |
Amadis Chemical Company Limited | 571-89925085 | China | 131980 | 58 | Inquiry |
186611-52-9(IC 261)Related Search:
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SU5607, 1,3-Dihydro-3-[(2,4,6-trimethoxyphenyl)methylene]-2H-indol-2-one
1,3-Dihydro-3-[(2,4,6-triMethoxyphenyl)Methylene]-2H-indol-2-one, SU5607
SU-5607 IC 261
(E)-3-(2,4,6-trimethoxybenzylidene)indolin-2-one
IC261, >98%
IC-261(SU-5607)
IC261 - CAS 186611-52-9 - Calbiochem
IC261;SU5607;IC 261;SU 5607
CS-1551
3-(2,4,6-Ttrimethoxybenzylidene)indolin-2-one
IC261,Inhibitor,Apoptosis,IC-261,inhibit,IC 261,Casein Kinase
186611-52-9
Inhibitors