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HARRINGTONINE

HARRINGTONINE Structure
CAS No.
26833-85-2
Chemical Name:
HARRINGTONINE
Synonyms
HT;nsc124147;(3(r))-ter;HARRINGTONIN;HARRINGTONINE;2'R-HARRINGTONINE;HARRINGTONINE98%,99%;Harringtonine 26833-85-2;alkaloidcfromcephalotaxus;HARRINGTONINE(P) USP/EP/BP
CBNumber:
CB2702955
Molecular Formula:
C28H37NO9
Molecular Weight:
531.6
MOL File:
26833-85-2.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:04

HARRINGTONINE Properties

Melting point 73~75℃
Boiling point 679.4±55.0 °C(Predicted)
Density 1.35±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form A crystalline solid
pka 11.62±0.29(Predicted)
color White to light yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H310-H300-H330
Precautionary statements  P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501
RIDADR  1544
HazardClass  6.1(a)
PackingGroup  II
NFPA 704
0
4 0

HARRINGTONINE Chemical Properties,Uses,Production

Description

The full structure of harringtonine has now been established from a study of the hydrolysis products of this base.

Chemical Properties

White Solid

Uses

A natural product with significant antitumor activities.

References

Mikolajczak, Powell, Smith, Tetrahedron, 28, 1995 (1972)
Kelly, McKenna, Christenson, Tetrahedron Lett., 35m (1973)

HARRINGTONINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(3(r))-ter 4-methyl-cephalotaxin2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate(es alkaloidcfromcephalotaxus cephalotaxine,4-methyl(2r)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioat nsc124147 HARRINGTONIN HARRINGTONINE HT 2'R-HARRINGTONINE Cephalotaxine, 4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate (ester) HARRINGTONINE98%,99% 2’R-Harringtonine,Harringtonin 3-[4-Methyl (2R)-2-hydroxy-2-(3-hydroxy-3-Methylbutyl)butanedioate]cephalotaxine 3-methylbutyl)butanedioate (ester), [3(R)]- Cephalotaxine, 4-methyl 2-hydroxy-2-(3-hydroxy- 2-Hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioic acid 1-[(3R)-3-deoxycephalotaxin-3-yl]4-methyl ester Harringtonine, 98%, from Taxus chinensis (Pilg.) Rehder Harringtonine 26833-85-2 Cephalotaxine, 3-[4-methyl (2R)-2-hydroxy-2-(3-hydroxy-3-methylbutyl)butanedioate] HARRINGTONINE(P) USP/EP/BP 26833-85-2 C28H37NO9 Intermediates & Fine Chemicals Pharmaceuticals Alkaloids