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apovincamine

apovincamine Structure
CAS No.
4880-92-6
Chemical Name:
apovincamine
Synonyms
Apovincamina;apovincamine;Apovincaminum;Vinpocetine-2;Unii-504R182zx7;Einecs 225-491-0;cis-ApovincaMine;(+)-trans-Cavinton;(+)-trans-Cavinton;Apovincaminum [latin]
CBNumber:
CB2890058
Molecular Formula:
C21H24N2O2
Molecular Weight:
336.43
MOL File:
4880-92-6.mol
MSDS File:
SDS
Modify Date:
2024/8/8 18:06:34
Request For Quotation

apovincamine Properties

Melting point 160-162℃
Boiling point 405.7±45.0 °C(Predicted)
Density 1.30±0.1 g/cm3(Predicted)
storage temp. Refrigerator
solubility Chloroform (Slightly), Methanol (Slightly)
pka 7.82±0.60(Predicted)
color Off-White to Pale Grey

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
HS Code  2939800000

apovincamine price More Price(1)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PHR3634 Vinpocetine Related Compound B certified reference material, pharmaceutical secondary standard 4880-92-6 50MG ₹71315.1 2022-06-14 Buy
Product number Packaging Price Buy
PHR3634 50MG ₹71315.1 Buy

apovincamine Chemical Properties,Uses,Production

Originator

Apovincamine,GC Promochem

Manufacturing Process

Apovincamine is semisynthethetic derivative of (+)-vincamine. Vincamine is alkaloid of Vinca minor. Alcoloid of Tabernaemontana rigida (Apocynaceae) also is used as raw material for preparing of apovincamine. (+)- Vincamine was transformed into oxime ester by reaction with NaNO2 in acetic acid at 0°C -(+/-)-methyl-3-((12bR)-1-ethyl-1,2,3,4,6,7,12,12b-octahydroindolo[2,3- a]quinolizin-1-yl)-2-(hydroxyimino)propanoate, which was resolved on the isomers with dibenzoyl D-tartratic acid. (-)-Methyl 3-((12bR)-1-ethyl- 1,2,3,4,6,7,12,12b-octahydroindolo[2,3-a]quinolizin-1-yl)-2- (hydroxyimino)propanoate was re-crystallized from methanol to afford (-)- methyloxime ester, MP: 195°C.
2 g of above oxime methyl ester was heated in mixture of methanol (37.5 ml) and conc. H2SO4 (13.5 ml) on water bath for 1 hour. The solution was poured into ice-water (80 ml), basified with conc. NH4OH to pH 9, and extracted with CH2Cl2 (3x20 ml). The combined extracts were dried (MgSO4), filtered, evaporated in vacuum and the residue was re-crystallized from MeOH (5 ml) to yield 1.32 g (72.5%) of (+)-apovincamine, MP: 160°-162°C.

Therapeutic Function

Vasodilator

apovincamine Preparation Products And Raw materials

Raw materials

L(+)-Tartaric acid DIBENZOATE Vincamine Dibenzoyltartaric acid

Preparation Products

apovincamine Suppliers

Global( 51)Suppliers
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CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd +91-172-5066494 Haryana, India 6773 58 Inquiry
Shaanxi Dideu Medichem Co. Ltd 18192627656 China 3002 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30250 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
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PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD 0371-55159968 18137130222 China 527 58 Inquiry
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CLEARSYNTH LABS LTD. 58
Pharmaffiliates Analytics and Synthetics P. Ltd 58
Shaanxi Dideu Medichem Co. Ltd 58
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 58
China National Standard Pharmaceutical Corporation Limited 58
PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD 58
ROSEWA HOLDING GROUP CO.,LIMITED 58
cjbscvictory 58

4880-92-6(apovincamine)Related Search:

Vinpocetine ApovincaMinic Acid Ethyl Ester N-Oxide methyl (41R,12R,13aS)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate methyl (3alpha,14alpha,16alpha)-14,15-dihydro-14-hydroxyeburnamenine-14-carboxylate (41S,12S,13aS)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylic acid
methyl (41R,12S,13aS)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate methyl (41S,12S,13aS)-13a-ethyl-12-hydroxy-8-methoxy-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate ethyl (41R,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (+)-(14β)-Dihydrovinpocetine (-)-DihydroapovincaMinic Acid Ethyl Ester
ethyl (41S,12R,13aS)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate ethyl (41S,13aR)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate methyl (41R,12R,13aR)-13a-ethyl-12-hydroxy-2,3,41,5,6,12,13,13a-octahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate 16,17-Dihydroapovincamine sodium (41S,13aS)-13a-ethyl-2,3,41,5,6,12,13,13a-octahydro- 1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12- carboxylate
methyl (41S,12R,13aR)-13a-ethyl-12- hydroxy-2,3,41,5,6,12,13,13aoctahydro- 1H-indolo[3,2,1- de]pyrido[3,2,1-ij][1,5]naphthyridine- 12-carboxylate (3alpha,16alpha)-eburnamenine-14-carboxylic acid ethyl apovincaminate
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Methyl (3alpha,16alpha)-eburnamenine-14-carboxylate apovincamine Methyl (13aS,13bS)-13a-ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate methyl (41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate (3α,16α)-Eburnamenine-14-carboxylic acid methyl ester Apo-14,15-dehydrovincamine Apovincaminic acid methyl (+)-trans-Cavinton Apovincamina Apovincamina [spanish] Apovincaminum Apovincaminum [latin] Eburnamenine-14-carboxylic acid, methyl ester, (3-alpha,16-alpha)- Einecs 225-491-0 Methyl (13as,13bs)-13A-ethyl-2,3,4,6,13A,14B-hexahydro-1H-indilol(3.2.1-de)pyrido(3,2,1-ij)(1,5)naphthylridin-12-carboxylat Unii-504R182zx7 Vinpocetine Related Compound B (30 mg) (methyl (13aS,13bS)-13a-ethyl-9-methoxy-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate) IMp. B (EP): Methyl (13aS,13bS)-13a-Ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1- de]pyrido[3,2,1-ij][1,5]naphthyridine-12- carboxylate (ApovincaMine) Vinpocetine IMp. B (EP) cis-ApovincaMine Vinpocetine Related CoMpound B Vincamine EP Impurity B Vinpocetine EP Impurity B methyl (41S,13aS)-13a-ethyl-2,3,41,5,6,13a-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]phthyridine-12-carboxylate Vinpocetine-2 (41S,13aS)-methyl 13a-ethyl- Methyl (13aS,13bS)-13a-Ethyl-2,3,5, Vinpocetine impurity B CRS Eburnamenine-14-carboxylic acid, methyl ester, (3α,16α)- (+)-trans-Cavinton Vinpocetine Related Compound B(Secondary Standards traceble to USP) Vinpocetine Related Compound B (Methyl(13aS,13bS)-13a-ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2 (1714620) Vinpocetine impurity B (apovincamine) Vinpocetine USP Related Compound B methyl14,15-didehydrovincane-14-carboxylate(apovincamine) methyl(13aS,13bS)-13a-ethyl-2,3,5,6,13a,13b-hexahydro-1H-indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine-12-carboxylate(apovincamine) Vincamine EP Impurity D (+)-apovincamine, cis-apovincamine 4880-92-6