Chloramphenicol hemisuccinate
- CAS No.
- 3544-94-3
- Chemical Name:
- Chloramphenicol hemisuccinate
- Synonyms
- Chronicin foam;Paraxin succinate;Kemicetine succinate;Levomycetin succinate;Chloromycetin succinate;Chloramphenicol succinate;Levomycetin hemisuccinate;Chloramphenicol 3-succinate;Chloramphenicol hemisuccinate;Chloramphenicol monosuccinate
- CBNumber:
- CB2925965
- Molecular Formula:
- C15H16Cl2N2O8
- Molecular Weight:
- 423.2
- MOL File:
- 3544-94-3.mol
- Modify Date:
- 2023/6/8 9:02:56
| Melting point | 127 °C |
|---|---|
| Boiling point | 716.3±60.0 °C(Predicted) |
| Density | 1.6769 (rough estimate) |
| refractive index | 1.7350 (estimate) |
| storage temp. | Store at -20°C |
| solubility | DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble |
| form | A solid |
| pka | 4.36±0.17(Predicted) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H302-H332-H335-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P261-P271-P304+P340-P312-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 | |||||||||
| NFPA 704 |
|
Chloramphenicol hemisuccinate Chemical Properties,Uses,Production
Description
Chloramphenicol succinate is a water-soluble prodrug form of the antibiotic chloramphenicol. It is a substrate for succinate dehydrogenase (SDH) and is oxidized by human liver and rat liver and kidney mitochondria to release chloramphenicol in vitro. Chloramphenicol succinate reduces human leukocyte migration in vitro. In vivo, chloramphenicol succinate reduces E. coli growth in rabbit and rat models of pyelonephritis when administered at doses of 150 and 200 mg/kg, respectively. Chloramphenicol succinate (20 mg/kg) reduces infarct size in a porcine model of myocardial ischemia-reperfusion injury. Formulations containing chloramphenicol succinate have been used in the treatment of severe bacterial infections.
Uses
Chloramphenicol succinate is prepared by acylation of chloramphenicol with succinic anhydride to provide a water soluble pro-drug. Chloramphenicol succinate represents an alternative pro-drug strategy for chloramphenicol that has found a niche in surface antibiotic treatment in surgery. Chloramphenicol succinate is significantly less active than chloramphenicol but acts as a prodrug, forming chloramphenicol in the presence of succinate dehydrogenase.
Chloramphenicol hemisuccinate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| ShreeGen Pharma Ltd (part of Rumit Group of Companies) | +91-4023869399 +91-9664830616 | Telangana, India | 25 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Nabros Pharma Private Limited | 08048372725Ext 851 | Ahmedabad, India | 2 | 58 | Inquiry |
| Cardkem Pharma Pvt Ltd | 08048361295Ext 942 | Gujarat, India | 14 | 58 | Inquiry |
| Noblemeds And Surgicals Private Limited | 08048988975 | Nagpur, India | 12 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | China | 15395 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
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