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PEROSPIRONE

PEROSPIRONE Structure
CAS No.
150915-41-6
Chemical Name:
PEROSPIRONE
Synonyms
Perospirine;PEROSPIRONE;PEROSPIRONE HCL;[14C]-Perospirone;PerospironeQ: What is Perospirone Q: What is the CAS Number of Perospirone;cis-N-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cyclohexanedicarboximide;(1R,2S)-N-[4-[4-(1,2-Benzisothiazole-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarbimide;1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, cis-;(3aα,7aα)-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H-isoindole-1,3(2H)-dione;(3aR,7aS)-2-[4-[4-(1,2-benzothiazol-3-yl)-1-piperazinyl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione
CBNumber:
CB3101658
Molecular Formula:
C23H30N4O2S
Molecular Weight:
426.57
MOL File:
150915-41-6.mol
MSDS File:
SDS
Modify Date:
2023/5/21 10:59:17
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PEROSPIRONE Properties

storage temp. Store at -20°C
solubility Soluble in DMSO
form Solid
color White to Off-White

PEROSPIRONE Chemical Properties,Uses,Production

Description

Perospirone hydrochloride was launched in Japan as a new treatment of schizophrenia and other psychoses. This structurally-related analog of ziprasidone can be classically prepared by alkylation of 1-(3-benzisothiazolyl)-piperazine with the appropriate N- (chlorobutyl)-succinimide. As a result of an in vitro determination of its binding profile, perospirone demonstrated a high affinity for 5-HT2, 5-HT1A and D2 receptors as well as a significant but lower affinity for DI and al receptors. Interestingly, these differential effects on neurotransmitters with a high in vivo occupancy of 5-HT2A receptors with lower D2 occupancy seems to provide this new agent with a significantly lower propensity for the development of extrapyramidal symptoms (EPS) and tardive schizophrenia, the main sideeffects associated with classical antipsychotic therapy. Furthermore, perospirone exhibited anxiolytic-like effects in animal models. A long-term clinical trial (> 6 months) in a group of patients suffering from schizophrenia demonstrated the efficacy of perospirone over placebo for the treatment of the positive, negative and general symptoms of schizophrenia at doses of 12 mg to 96 mg t.i.d.

Originator

Sumitomo Pharm. (Japan)

brand name

Lullan

PEROSPIRONE Preparation Products And Raw materials

Raw materials

3-Chloro-1,2-benzisothiazole 3-(1-Piperazinyl)-1,2-benzisothiazole

Preparation Products

PEROSPIRONE Suppliers

Global( 56)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. 571-88938639 +8617705817739 China 52861 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
PT CHEM GROUP LIMITED China 35426 58 Inquiry
GIHI CHEMICALS CO.,LIMITED +8618058761490 China 50000 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Sequoia Research Products Ltd. 44 7802 291086 United Kingdom 3115 69 Inquiry
QVENTAS INC. 203 481 4560 United States 383 47 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6846 58 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
Dayang Chem (Hangzhou) Co.,Ltd. 58
TargetMol Chemicals Inc. 58
PT CHEM GROUP LIMITED 58
GIHI CHEMICALS CO.,LIMITED 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Sequoia Research Products Ltd. 69
QVENTAS INC. 47
Shanghai Hao Zhun Biological Technology Co., Ltd. 58

150915-41-6(PEROSPIRONE)Related Search:

1,2-Cyclohexanedicarboximide 1,2-Cyclohexanedicarboximide etisazole PEROSPIRONE 3-Piperazinobenzisothiazole hydrochloride
PEROSPIRONE HYDROCHLORIDE DIHYDRATE,PEROSPIRONE HYDROCHLORIDE HYDRATE,PEROSPIRONE HYDROCHLORIDE,Perospirone Hydrochloride Trihydrate cis-Octahydroisoindole 1,2-Benzisothiazol-3-amine
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PEROSPIRONE PEROSPIRONE HCL 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, (3aR,7aS)-rel- (9CI) 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, cis- cis-N-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]-1,2-cyclohexanedicarboximide Perospirine (1R,2S)-N-[4-[4-(1,2-Benzisothiazole-3-yl)-1-piperazinyl]butyl]cyclohexane-1,2-dicarbimide (3aα,7aα)-2-[4-[4-(1,2-Benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-1H-isoindole-1,3(2H)-dione (3aS,7aR)-2-[4-[4-(1,2-Benzothiazol-3-Yl)Piperazin-1-Yl]Butyl]-3a,4,5,6,7,7a-Hexahydroisoindole-1,3-Dione (3aR,7aS)-2-[4-[4-(1,2-benzothiazol-3-yl)-1-piperazinyl]butyl]-3a,4,5,6,7,7a-hexahydroisoindole-1,3-dione [14C]-Perospirone 1H-Isoindole-1,3(2H)-dione, 2-[4-[4-(1,2-benzisothiazol-3-yl)-1-piperazinyl]butyl]hexahydro-, (3aR,7aS)-rel- PerospironeQ: What is Perospirone Q: What is the CAS Number of Perospirone deficits,atypical,Perospirone,SM-9018,Dopamine Receptor,5-hydroxytryptamine Receptor,5-HT Receptor,Orally,SM9018,schizophrenic,disease,Serotonin Receptor,cognitive,Inhibitor,SM 9018,inhibit,antipsychotic 150915-41-6 C23H30N4O2S