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Fiacitabine

Fiacitabine Structure
CAS No.
69123-90-6
Chemical Name:
Fiacitabine
Synonyms
FOAC;FIAC;NSC382097;NSC 382097;NSC -82097;Fiacitabine;NSC-382097;FIAC;FICA, NSC382097, FOAC;Fiacitabine (NSC-382097;FOAC|||FIAC|||NSC 382097
CBNumber:
CB31178749
Molecular Formula:
C9H11FIN3O4
Molecular Weight:
371.1
MOL File:
69123-90-6.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:04
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Fiacitabine Properties

Boiling point 524.6±60.0 °C(Predicted)
Density 2.44±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO: ≥ 37 mg/mL (99.70 mM)
pka 12.84±0.70(Predicted)
form Powder
color White to off-white

Fiacitabine Chemical Properties,Uses,Production

Description

Fiacitabine is a pyrimidine nucleoside analog with activity against various herpesviruses. It is converted to its triphosphate form in vivo and inhibits viral DNA polymerase. It has been used in trials studying the treatment of HIV Infections and Cytomegalovirus Infections.

Preparation

The preparation method for Fecitabine involves using 2-deoxy-2-fluoro-tribenzoyl-α-D-arabinofuranose as the raw material. The arabinofuranose is brominated with the hydrobromic acetic acid solution under normal room temperature conditions to obtain 2-deoxy-2-fluoro-tribenzoyl-α-D-brominated arabinofuranose. Next, cytosine is used as the raw material for iodination and is Bz-protected to obtain -(5-Iodo-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide, which serves as the final intermediate. After the reaction, deprotection is carried out to obtain Fecitabine with a total yield as high as 43%.?

Mode of action

Fiacitabine is an antimicrobial agent that inhibits microbial growth by binding to the ribosomal 30S subunit and blocking protein synthesis. It is a prodrug that is converted to 5-fluorocytosine (5FC) in the liver, where it inhibits the activity of the enzyme dihydropyrimidine dehydrogenase, thereby interfering with DNA replication.

Fiacitabine Preparation Products And Raw materials

Raw materials

Cytosine 2-deoxy-2-fluoro-3-phenylpropanoyl-α-D-arabinofuranose

Preparation Products

Fiacitabine Suppliers

Global( 56)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Shenzhen Nexconn Pharmatechs Ltd +86-755-89396905 +86-15013857715 China 10318 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD. +86-021-61551413 +8618813727289 China 5738 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 +1-00000000000 United States 19892 58 Inquiry
Career Henan Chemica Co +86-0371-86658258 +8613203830695 China 30253 58 Inquiry
NewCan Biotech Limited +86-0571-86912261 +8613735419629 China 9980 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD 0371-55159968 18137130222 China 466 58 Inquiry
Supplier Advantage
Capot Chemical Co.,Ltd. 60
Shenzhen Nexconn Pharmatechs Ltd 58
BOC Sciences 58
CONIER CHEM AND PHARMA LIMITED 58
SHANGHAI T&W PHARMACEUTICAL CO., LTD. 58
TargetMol Chemicals Inc. 58
Career Henan Chemica Co 58
NewCan Biotech Limited 58
LEAPCHEM CO., LTD. 58
PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD 58

69123-90-6(Fiacitabine)Related Search:

N,N-DIETHYLBENZAMIDE Aspartate aminotransferase 5-IODOCYTOSINE 5-Iodo-2'-deoxycytidine 5-Iodo-2-pyrimidone
Fiacitabine
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5-Iodo-2'-deoxy-2'-fluoro-beta-D-arabinocytidine Fiacitabine 2(1H)-Pyrimidinone, 4-amino-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodo- 4-aMino-1-(2-deoxy-2-fluoro-b-D-arabinofuranosyl)-5-iodo- FIAC FOAC NSC 382097 NSC382097 4-Amino-1-[(2R,3S,4R,5R)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-iodopyrimidin-2-one 1-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine NSC 382097; FIAC; FOAC;NSC382097; NSC -82097 NSC -82097 5-Iodo-2’-deoxy-2’-fluoro-beta-D-arabinocytidine, Fiacitabine 5-Iodo-2’-deoxy-2’-fluoro-β-D-arabinocytidine NSC-382097;FIAC Fiacitabine (NSC-382097 FICA, NSC382097, FOAC 1-(2-Deoxy-2-fluoro-beta-D-arabinofuranosyl)-5-iodocytosine Fiacitabine,NSC-382097,NSC382097,Herpes simplex virus,HSV,inhibit,Inhibitor 5-Iodo-2’-deoxy-2’-fluoro-beta-D-arabino cytidine FOAC|||FIAC|||NSC 382097 69123-90-6 C9H11FIN3O4