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ACONINE

CAS No.: 509-20-6

Chemical Name:: ACONINE

Synonyms: ACONINE;Aconitysat;Jesaconine;ACONINE USP/EP/BP;Aconine (Jesaconine);20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13...;20-Ethyl-1α,6α,16β-trimethoxy-4-(methoxymethyl)aconitane-3α,8,13,14α,15α-pentol;(15S,16S)-20-Ethyl-1α,6α,16-trimethoxy-4-(methoxymethyl)aconitane-3α,8β,13β,14α,15-pentol;Aconitane-3,8,13,14,15-pentol,20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, (1a,3a,6a,14a,15a,16b)-;Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, (1α,3α,6α,14α,15α,16β)-

CBNumber:: CB31229467

Molecular Formula:: C25H41NO9

Molecular Weight:: 499.6

MOL File:: 509-20-6.mol

MSDS File:: SDS

Modify Date:: 2023/8/24 17:20:48

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ACONINE Properties

Melting point	129-131℃
alpha	D +23°
Boiling point	590.79°C (rough estimate)
Density	1.42
refractive index	1.6000 (estimate)
storage temp.	-20°C Freezer
solubility	Chloroform (Slightly), DMSO (Slightly)
pka	9.52(at 25℃)
form	Solid
color	Off-White to Pale Yellow

ACONINE Chemical Properties,Uses,Production

Description

Aconine is an alkaloid originally isolated from Aconitum species and active metabolite of aconitine. It inhibits osteoclast differentiation of RANKL-stimulated RAW 264.7 cells and bone resorption in a pit formation assay in a concentration-dependent manner. Aconine also inhibits RANKL-induced activation of NF-κB and NFATc1 in RAW 264.7 cells. In vivo, aconine is toxic to mice when administered intravenously at a dose of 120 mg/kg. It induces flaccid paralysis and toxicity in rats with toxic dose (TD₅₀) and LD₅₀ values of 1.5 and 1.7 μmol per animal, respectively.

ACONINE Preparation Products And Raw materials

Raw materials

Preparation Products

ACONINE Suppliers

Global( 121)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Shaanxi Haibo Biotechnology Co., Ltd	+undefined18602966907	China	1000	58	Inquiry
Hangzhou FandaChem Co.,Ltd.	008657128800458; +8615858145714	China	9343	55	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29888	58	Inquiry
Chengdu GLP biotechnology Co Ltd	028-87075086 13350802083	CHINA	1824	58	Inquiry
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	China	3772	58	Inquiry
BOC Sciences	+1-631-485-4226	United States	19553	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Hubei Ipure Biology Co., Ltd	+8613367258412	China	10326	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	China	34571	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24099	58	Inquiry

Supplier	Advantage
Shaanxi Haibo Biotechnology Co., Ltd	58
Hangzhou FandaChem Co.,Ltd.	55
career henan chemical co	58
Chengdu GLP biotechnology Co Ltd	58
Chengdu Biopurify Phytochemicals Ltd.	58
BOC Sciences	58
Chongqing Chemdad Co., Ltd	58
Hubei Ipure Biology Co., Ltd	58
Hefei TNJ Chemical Industry Co.,Ltd.	58
Dideu Industries Group Limited	58

Aconine – an alkaloid from Aconitum species
Aconine is an alkaloid originally isolated from Aconitum species and active metabolite of aconitine [1]. It inhibits osteoclas....
Dec 24，2019

509-20-6(ACONINE)Related Search:

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ACONINE (15S,16S)-20-Ethyl-1α,6α,16-trimethoxy-4-(methoxymethyl)aconitane-3α,8β,13β,14α,15-pentol 20-Ethyl-1α,6α,16β-trimethoxy-4-(methoxymethyl)aconitane-3α,8,13,14α,15α-pentol (1alpha,3alpha,6alpha,14alpha,15alpha,16beta)-20-Ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13,14,15-pentol Jesaconine Aconitane-3,8,13,14,15-pentol,20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, (1a,3a,6a,14a,15a,16b)- Aconine (Jesaconine) Aconitane-3,8,13,14,15-pentol, 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-, (1α,3α,6α,14α,15α,16β)- ACONINE USP/EP/BP 20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)aconitane-3,8,13... Aconitysat 509-20-6 C25H41NO9 Alkaloids chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM). standardized herbal extract