methyl orsellinate
![methyl orsellinate Structure](CAS/GIF/3187-58-4.gif)
- CAS No.
- 3187-58-4
- Chemical Name:
- methyl orsellinate
- Synonyms
- Methyl;METHYL ORSELLINATE;Methyl o-orsellinate;Orsellinic acid methyl;o-Orsellinic acid methyl;6-Methyl-β-resorcylicacidmethyl;6-Methyl-β-resorcylic acid methyl;BENZOIC ACID,2,4-DIHYDROXY-6-METHYL-, METHYL ESTER
- CBNumber:
- CB31484897
- Molecular Formula:
- C9H10O4
- Molecular Weight:
- 182.17
- MOL File:
- 3187-58-4.mol
- Modify Date:
- 2024/7/9 13:10:46
Melting point | 141-142℃ |
---|---|
Boiling point | 339℃ |
Density | 1.296 |
Flash point | 138℃ |
storage temp. | 2-8°C |
solubility | Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly) |
form | Solid |
pka | 8.27±0.23(Predicted) |
color | White to Off-White |
InChI | InChI=1S/C9H10O4/c1-5-3-6(10)4-7(11)8(5)9(12)13-2/h3-4,10-11H,1-2H3 |
InChIKey | NCCWCZLEACWJIN-UHFFFAOYSA-N |
SMILES | C(OC)(=O)C1=C(C)C=C(O)C=C1O |
LogP | 2.380 (est) |
EPA Substance Registry System | Benzoic acid, 2,4-dihydroxy-6-methyl-, methyl ester (3187-58-4) |
methyl orsellinate Chemical Properties,Uses,Production
Uses
Methyl 2,4-Dihydroxy-6-methylbenzoate (methyl orsellinate) is a useful synthetic intermediate in the synthesis of Grifolic Acid (G786500); a selective partial GPR120 agonist. Grifolic Acid induces ERK and [Ca2+]i responses in cells expressing GPR120, but has no effects on those expressing GPR40.
Biochem/physiol Actions
Methyl orsellinate, an antifungal compound, is produced during submerged culture from Sparassis crispa. Methyl orsellinate have appeared to have higher antifungal activity than sparassol. Methyl orsellinate is a phytotoxic compound; it can cause significant inhibition of radicle growth of Amaranthus hypochondriacus and Echinochloa crus-galli, interact with bovine-brain calmodulin and inhibit the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase. It could inhibit PTP1B activity with 50% inhibitory concentration values of 277 +/- 8.6 microM; the selective inhibition of PTP1B has been widely recognized as a potential drug target for the treatment of type 2 diabetes and obesity; methyl orsellinate may treat the type 2 diabetes and obesity.
methyl orsellinate Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | Inquiry |
---|---|---|---|---|---|
A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
Zhengzhou Anbu Chem Co.,Ltd | +86-0371-88006763; +8615988602810 | China | 3000 | 58 | Inquiry |
Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-18789408387 | China | 3406 | 58 | Inquiry |
Xiamen Work-For-World Medicine Co.,Ltd. | +undefined15921822462 | China | 235 | 58 | Inquiry |
career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
WinWin Chemical CO., Limited | +86-0086-577-64498589 +86-15355981851 | China | 14278 | 58 | Inquiry |
LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
PNP Biotech Co. Ltd | +8618516098983 | China | 1001 | 58 | Inquiry |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |
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