ecallantide
- CAS No.
- 460738-38-9
- Chemical Name:
- ecallantide
- Synonyms
- DX 88;ecallantide;Cys16-Cys40;Cys32-Cys53);ecallantide USP/EP/BP;H-Glu-Ala-Met-His-Ser-Phe-Cys-Ala-Phe-Lys-Ala-Asp-Asp-Gly-Pro-Cys-Arg-Ala-Ala-His-Pro-Arg-Trp-Phe-Phe-Asn-Ile-Phe-Thr-Arg-Gln-Cys-Glu-Glu-Phe-Ile-Tyr-Gly-Gly-Cys-Glu-Gly-Asn-Gln-Asn-Arg-Phe-Glu-Ser-Leu-Glu-Glu-Cys-Lys-Lys-Met-Cys-Thr-Arg-Asp-OH(Disulfide bridge：Cys7-Cys57
- CBNumber:
- CB31508597
- Molecular Formula:
- C305H442N88O91S8
- Molecular Weight:
- 7053.82798
- MOL File:
- 460738-38-9.mol
- Modify Date:
- 2023/11/15 17:17:25
ecallantide Chemical Properties,Uses,Production
Description
Ecallantide, also known as DX-88, was approved in 2009 in the United States for treatment of hereditary angioedema (HAE), a condition characterized by episodic attacks of localized edema in cutaneous and mucosal tissues. HAE results from deficiencies or disorders of C1-esterase inhibitor protein (C1- 1NH). Mutation of the gene that encodes C1-1NH causes the lack or altered activity of the serine protease, C1-1NH. C1-1NH regulates the kallikrein–kinin (contact activation) and complement cascade systems. Ecallantide (DX-88) was designed to inhibit the action of plasma kallikrein. Ecallantide is a potent and selective inhibitor of plasma kallikrein with a Ki= 25 pM. The discovery program that identified ecallantide used phage display technology and a library of designed variants of the first Kunitz domain of TFPI. Ecallantide, a 60-amino acid peptide, with 3-disulfide bonds, differs from TFPI by 7-amino acids. Ecallantide has been developed as a subcutaneous administered formulation.
Uses
Treatment of hereditary angioedema; reduction of blood loss during cardiothoracic surgery (plasma kallikrein inhibitor).
ecallantide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | China | 616 | 58 | Inquiry |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10311 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24200 | 58 | Inquiry |
| Wuhan Fortuna Chemical Co., Ltd | +86-027-59207850 | China | 5989 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Henan Alfa Chemical Co., Ltd | +8618339805032 | China | 13183 | 58 | Inquiry |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | China | 2944 | 58 | Inquiry |
| CONTIDE BIOTECH CO.,LTD | +44-7438349267 +44-7438349267 | China | 562 | 58 | Inquiry |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 +86-17380623303 | China | 4887 | 58 | Inquiry |
| MOTIF BIOTECH.,Ltd | 0512-66891112-807 17805067858 | China | 136 | 58 | Inquiry |