ChemicalBook > Product Catalog >Organic Chemistry >Ketones >2-Methyl-4H-3,1-benzoxazin-4-one

2-Methyl-4H-3,1-benzoxazin-4-one

CAS No.: 525-76-8

Chemical Name:: 2-Methyl-4H-3,1-benzoxazin-4-one

Synonyms: NSC 10119;NSC 521353;ACETANTHRANIL;AURORA KA-3785;Acetylanthranyl;ACETYL ANTHRANIL;TIMTEC-BB SBB000135;2-METHYL-3,1-BENZOXAZA-4-ONE;2-methyl-3,1-benzoxazin-4-one;2-methyl-4h-1-benzoxazin-4-one

CBNumber:: CB3163296

Molecular Formula:: C9H7NO2

Molecular Weight:: 161.16

MOL File:: 525-76-8.mol

Modify Date:: 2024/7/5 11:27:04

Request For Quotation

2-Methyl-4H-3,1-benzoxazin-4-one Properties

Melting point	79-82 °C(lit.)
Boiling point	144-145 °C(Press: 12 Torr)
Density	1.25±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
pka	2.84±0.20(Predicted)
InChI	InChI=1S/C9H7NO2/c1-6-10-8-5-3-2-4-7(8)9(11)12-6/h2-5H,1H3
InChIKey	WMQSKECCMQRJRX-UHFFFAOYSA-N
SMILES	N1C2=CC=CC=C2C(=O)OC=1C
EPA Substance Registry System	4H-3,1-Benzoxazin-4-one, 2-methyl- (525-76-8)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H315-H319-H335
Precautionary statements	P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
WGK Germany	3
HazardClass	IRRITANT

2-Methyl-4H-3,1-benzoxazin-4-one price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	457752	2-Methyl-4H-3,1-benzoxazin-4-one 98%	525-76-8	10G	₹4530	2022-06-14	Buy

Product number	Packaging	Price	Buy
457752	10G	₹4530	Buy

2-Methyl-4H-3,1-benzoxazin-4-one Chemical Properties,Uses,Production

Uses

2-Methyl-4H-3,1-benzoxazin-4-one is a synthetic antimicrobial agent. It belongs to the quinazolinone class of drugs. It has been shown to be effective against Staphylococcus aureus and other bacteria. Quinazolinones are potent inhibitors of bacterial growth and have been used successfully in the treatment of tuberculosis and other infectious diseases. 2-Methyl-4H-3,1-benzoxazin-4-one has also been shown to inhibit the growth of some Gram-negative bacteria, such as Salmonella typhi and Escherichia coli.

Synthesis Reference(s)

The Journal of Organic Chemistry, 45, p. 363, 1980 DOI: 10.1021/jo01290a038

Synthesis

In 250 mL of RBF took (0.01 mole or 1.37 gm) anthranilic acid (2-amino benzoic acid) to that added 15 mL of acetic anhydride (excess) with porcelain chips. Reflux the solution at 35-40 ℃ for 50-55 min on heating mantle. TLC was done using EA: n-hexane (1:1) solvent system. Then removed the excess solvent (acetic anhydride) at low pressure using rotatory evaporator, To the remaining solid, added petroleum ether (40-60) to extract the 2-methyl-4H-3,1-benzoxazin-4-one. Repeated petroleum ether step to extract the entire product. After drying of petroleum-ether, the crystals of 2-methyl-4H-3, 1-benzoxazin-4-one was obtained and then it was recrystallized with ethanol8. M.P 80-82℃, Yield 79 %.
2-METHYL-3,1-BENZOXAZA-4-ONE

2-Methyl-4H-3,1-benzoxazin-4-one Preparation Products And Raw materials

Raw materials

2'-IODOACETANILIDE N-(2-ACETYL-PHENYL)-ACETAMIDE 2-Azidobenzoic acid PHENYL FORMATE carbon monoxide

Acetyl chloride N-Acetylanthranilic acid Methyl anthranilate 2-Iodoaniline Anthranilic acid

chevron_left

1of2

chevron_right

Preparation Products

1,2-DIHYDRO-4-HYDROXY-2-OXO-3-QUINOLINECARBOXYLIC ACID ETHYL ESTER METHAQUALONE

2-Methyl-4H-3,1-benzoxazin-4-one Suppliers

Global( 129)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
KROMOZOME	+91-91-9650900955 +91-09650900955	Maharashtra, India	71	58	Inquiry
SRIHARIDATTA LABORATORIES Pvt Ltd	+91-8074356448 +91-9966926662	Telangana, India	32	58	Inquiry
CSR Laboratories Pvt Ltd	+91-8712840214 +91-8897651070	Hyderabad, India	19	58	Inquiry
CHEMSWORTH	+91-261-2397244	New Delhi, India	6707	30	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Marvel pharm limited	+8613302302478	China	22	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-029-81148696 +8615536356810	China	943	58	Inquiry
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	China	20361	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry

Supplier	Advantage
KROMOZOME	58
SRIHARIDATTA LABORATORIES Pvt Ltd	58
CSR Laboratories Pvt Ltd	58
CHEMSWORTH	30
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Marvel pharm limited	58
Shaanxi Dideu Medichem Co. Ltd	58
Henan Fengda Chemical Co., Ltd	58
Capot Chemical Co.,Ltd.	60

525-76-8(2-Methyl-4H-3,1-benzoxazin-4-one)Related Search:

2-Methyl-4H-3,1-benzoxazin-4-one BENTRANIL AURORA 18390 2-(4-Nitrophenyl)-4H-3,1-benzoxazin-4-one AURORA 5332

2-(3-METHOXYPHENYL)-4H-3,1-BENZOXAZIN-4-ONE 2,6-dimethyl-4H-3,1-benzoxazin-4-one 2-(2-METHYLPHENYL)-4H-3,1-BENZOXAZIN-4-ONE 2-(4-FLUOROPHENYL)-4H-3,1-BENZOXAZIN-4-ONE 2-(o-Chlorophenyl)-4H-3,1-benzoxazin-4-one

2-(TRICHLOROMETHYL)-4H-3,1-BENZOXAZIN-4-ONE 2-(4-CHLOROPHENYL)-6-METHYL-4H-3,1-BENZOXAZIN-4-ONE AURORA 18389 2-(2-CHLOROPHENYL)-6-METHYL-4H-3,1-BENZOXAZIN-4-ONE 2-(3-nitrophenyl)-4H-3,1-benzoxazin-4-one

2-(CHLOROMETHYL)-4H-3,1-BENZOXAZIN-4-ONE AURORA KA-4769 2-(2,6-DICHLORO-4-PYRIDYL)-5-FLUORO-4H-3,1-BENZOXAZIN-4-ONE

chevron_left

1of4

chevron_right

TIMTEC-BB SBB000135 2-methyl-4h-1-benzoxazin-4-one 2-METHYL-3,1-BENZOXAZA-4-ONE 2-METHYL-4H-3,1-BENZOXAZIN-4-ONE ACETYL ANTHRANIL ACETANTHRANIL 2-2-METHYL-4H-3,1-BENZOXAZIN-4-ONE 4H-3,1-benzoxazin-4-one, 2-methyl- 2-methyl-3,1-benzoxazin-4-one 2-Methyl-benzo(d)(1,3)oxazin-4-one 2-Methyl-4H-benzo[d][1,3]oxazin-4-one 2-Methyl-3,1-benzoxazine-4-one 2-Methyl-4-oxo-3,1-benzoxazine 2-Methyl-4-oxo-4H-3,1-benzoxazine 2-Methylbenzo[1,3]oxazin-4-one Acetylanthranyl NSC 10119 NSC 521353 2-Methyl-4H-3,1-benzoxazin-4-one 98% 2-Methylbenzisoxazinone(2-Methyl-4H-3,1-Benzoxazin-4-One) AURORA KA-3785 3-methyl-1-phenyl-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-dione 2-Methyl-4H-3,1-benzoxazin-4-o Ortho acetamide benzoic acid lactone 2-Methyl-4H-benzo [d] [1,3]oxazin-4o 525-76-8 Benzoxazines Building Blocks Heterocyclic Building Blocks API intermediates Benzoxazines Building Blocks Heterocyclic Building Blocks