1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE

CAS No.: 168986-60-5

Chemical Name:: 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE

Synonyms: RS67333HCl;RS 67333 hydrochlori;RS 67333 HYDROCHLORIDE;RS 67333 hydrochloride >=98% (HPLC);1-(4-AMino-5-chloro-2-Methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one hydrochloride;1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE;1-Propanone, 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-, hydrochloride (1:1)

CBNumber:: CB3187740

Molecular Formula:: C19H30Cl2N2O2

Molecular Weight:: 389.36

MOL File:: 168986-60-5.mol

Modify Date:: 2024/7/2 8:55:05

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1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Properties

storage temp.	Store at RT
form	Powder
color	Light yellow to yellow
Water Solubility	Soluble to 25 mM in water with gentle warming

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML1882	RS 67333 hydrochloride ≥98% (HPLC)	168986-60-5	5MG	₹10619.33	2022-06-14	Buy
Sigma-Aldrich(India)	SML1882	RS 67333 hydrochloride ≥98% (HPLC)	168986-60-5	25MG	₹42877.83	2022-06-14	Buy

Product number	Packaging	Price	Buy
SML1882	5MG	₹10619.33	Buy
SML1882	25MG	₹42877.83	Buy

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Chemical Properties,Uses,Production

Uses

RS 67333 Hydrochloride is a 5-HT4 receptor agonist.

Biological Activity

A potent and highly selective 5-HT 4 partial agonist, with pK i values of 8.7 at 5-HT 4 sites in guinea pig striatum and > 6 at various other receptors, including 5-HT 1A , 1D , 2A , 2C , D 1 , D 2 and M 1-3 . Active in vivo , with an intrinsic activity relative to 5-HT of 0.5.

Biochem/physiol Actions

RS 67333 is a selective, high affinity (pKi = 8.7 for the 5-HT4 binding site in guinea-pig striatum) partial agonist toward 5-HT4 receptor that relaxes carbachol-contracted rat oesphageal muscularis mucosae ex vivo (pEC50/%reversal = 8.7/50 with RS 67333 vs. 8.2/100 with 5-HT) and induces tachycardia (tachyarrhythmia) of anaesthetized micropigs in vivo (ED50 via i.p. in μg/kg over max heart rate increase in beats/min = 4.9/35 with RS 67333 vs. 3.2/95 with 5-HT). RS 67333 is also reported to show high affinity for sigma receptors (pKi = 8.9/σ1 and 8.0/σ2), while exhibiting much reduced affinity toward a panel of other receptors, including 5-HT1A, 5-HT2A, 5-HT2C, 5-HT3 (pKi <6.4), muscarinic receptors (pKi = 5.2/M1 & 5.3/M2), and adrenoceptors (pKi <6.7 for α1A, α1B, α2A, α2B, β1, β2).

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Suppliers

Global( 49)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	+86-18341751992 +86-15382112998	China	892	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	52927	58	Inquiry
Wuhan Jingkang en Biomedical Technology Co., Ltd	+8613720134139	China	4692	58	Inquiry
Bide Pharmatech Ltd.	400-1647117 15221909166	China	63720	58	Inquiry
Wuhan Jingkangen Biomedical Technology Co., Ltd	13720134139 13720134139	China	5347	58	Inquiry
Shenzhen SUNGENING Bio-Medical Co., Ltd.	0755-28967200 13631290199	China	9592	60	Inquiry
Suzhou Zhixin Biotechnology Co., Ltd.	0512-65118909 15162312715	China	2992	58	Inquiry
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Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
TargetMol Chemicals Inc.	58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd	58
Aladdin Scientific	58
Wuhan Jingkang en Biomedical Technology Co., Ltd	58
Bide Pharmatech Ltd.	58
Wuhan Jingkangen Biomedical Technology Co., Ltd	58
Shenzhen SUNGENING Bio-Medical Co., Ltd.	60
Suzhou Zhixin Biotechnology Co., Ltd.	58
Shanghai SuperLan Chemcial Technique Centre	58

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE Spectrum

1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE(168986-60-5)¹HNMR

168986-60-5(1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE)Related Search:

Poly(hexamethylenebiguanide)hydrochloride Triethylamine hydrochloride 1-(4-Amino-2-hydroxy-phenyl)-propan-1-one 2-Chloro-5-methoxyaniline P-HEXYLANILINE HYDROCHLORIDE

1-(4-AMINO-3-CHLORO-PHENYL)-PROPAN-1-ONE 4-(3-PHENYL-PROPYL)-PIPERIDINE HCL 1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE 1-(4-AMINO-3-CHLORO-PHENYL)-ETHANONE 4-aminohexanoylphenone

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1-(4-AMINO-5-CHLORO-2-METHOXYPHENYL)-3-[1-BUTYL-4-PIPERIDINYL]-1-PROPANONE HYDROCHLORIDE RS 67333 HYDROCHLORIDE RS67333HCl 1-(4-AMino-5-chloro-2-Methoxyphenyl)-3-(1-butylpiperidin-4-yl)propan-1-one hydrochloride RS 67333 hydrochlori RS 67333 hydrochloride >=98% (HPLC) 1-Propanone, 1-(4-amino-5-chloro-2-methoxyphenyl)-3-(1-butyl-4-piperidinyl)-, hydrochloride (1:1) 168986-60-5 C19H30Cl2N2O2 C19H29ClN2O2HCl