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Ziconotide Polyacetate

CAS No.: 107452-89-1

Chemical Name:: Ziconotide Polyacetate

Synonyms: snx111;Ziconotide;ω-conotoxin mviia;OMEGA-CGTX MVII A;o-Conotoxin MVIIA;Zicontide Acetate;ω-Conotoxin MVIIA;ZICONOTIDE ACETATE;SNX-111, Ziconotide;OMEGA-CONOTOXIN MVIIA

CBNumber:: CB3190092

Molecular Formula:: C102H172N36O32S7

Molecular Weight:: 2639.13

MOL File:: 107452-89-1.mol

MSDS File:: SDS

Modify Date:: 2024/6/17 17:42:23

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Ziconotide Polyacetate Properties

Density	1.60±0.1 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO (Slightly, Sonicated), Methanol (Slightly)
form	Solid
color	White to Off-White
InChIKey	BPKIMPVREBSLAJ-QTBYCLKRSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301+H331
Precautionary statements	P261-P304+P340+P312-P403+P233
RIDADR	3172
WGK Germany	3
HazardClass	6.1(b)
PackingGroup	III

Ziconotide Polyacetate price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	C1182	ω-Conotoxin MVIIA ≥95% (HPLC)	107452-89-1	0.1MG	₹28199.13	2022-06-14	Buy
Sigma-Aldrich(India)	C1182	ω-Conotoxin MVIIA ≥95% (HPLC)	107452-89-1	0.5MG	₹101527.68	2022-06-14	Buy

Product number	Packaging	Price	Buy
C1182	0.1MG	₹28199.13	Buy
C1182	0.5MG	₹101527.68	Buy

Ziconotide Polyacetate Chemical Properties,Uses,Production

Description

ω-conotoxin MVIIA, also knwn as Ziconotide acetate, is a peptide consisting of 25 amino acid. It is a disulfide-bridged polypeptide from the venom of the sea snail Conusmagus that binds to neuronal N-type calcium channels. It forms a compact folded structure, presenting a loop between Cys8 and Cys15 that contains a set of residues critical for its binding. Both ω-conotoxins GVIA and MVIIA could bind to neuronal N-type calcium channels. ω-conotoxin GVIA is rich in hydroxyl groups while ω-conotoxin MVIIA contains a large number of positively charged side chains[1-2].

Uses

Ziconotide acetate (ω-Conotoxin MVIIA), the peptide toxin of the Conus magus (cone snail) is a selective antagonist of N-type voltage sensitive calcium channels (VSCC). As a most well-known identified conotoxin so far, it has been used as a effective drug to treat intractable chronic pain in cancer and ADIS patients[2]. Blocks neurotransmitter release by preventing depolarization-induced calcium influx. Used as a ligand for binding studies of voltage sensitive calcium channels. Analgesic; neuroprotective.

General Description

ω-Conotoxin MVIIA functions as a selective inhibitor of N-type voltage-sensitive calcium channels (VSCCs). It has analgesic and neuroprotective effects. ω-Conotoxin MVIIA is used to treat neuropathic pain.

References

[1] Wang R, et al. Development of an ic-ELISA and immunochromatographic strip based on IgG antibody for detection of ω-conotoxin MVIIA. Journal of Hazardous Materials, 2019; 378: 120510.
[2] Zhou Y, et al. A Chemoenzymatic Approach To Produce a Cyclic Analogue of the Analgesic Drug MVIIA (Ziconotide). Angew. Chem. Int. Ed., 2023; 62: e202302812.

Ziconotide Polyacetate Preparation Products And Raw materials

Raw materials

Preparation Products

Ziconotide Polyacetate Suppliers

Global( 198)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Hantai Biomedical Group Co. LTD	+8618819265912	China	37	58	Inquiry
henan kanbei chemical co.,ltd	+undefined-86-1523780-4566 +undefined15237804566	China	511	58	Inquiry
Henan Bao Enluo International TradeCo.，LTD	+86-17331933971 +86-17331933971	China	2503	58	Inquiry
Wuhan Haorong Biotechnology Co.,ltd	+86-18565342920; +8618565342920	China	289	58	Inquiry
Zibo Hangyu Biotechnology Development Co., Ltd	+86-0533-2185556 +8617865335152	China	10978	58	Inquiry
Nantong Guangyuan Chemicl Co,Ltd	+undefined17712220823	China	616	58	Inquiry
Henan Fengda Chemical Co., Ltd	+86-371-86557731 +86-13613820652	China	20296	58	Inquiry
Shanghai Affida new material science and technology center	+undefined15081010295	China	114	58	Inquiry
Alpha Biopharmaceuticals Co., Ltd	+86-15542445688	China	888	58	Inquiry
Shanghai Daken Advanced Materials Co.,Ltd	+86-371-66670886	China	16859	58	Inquiry

Supplier	Advantage
Hantai Biomedical Group Co. LTD	58
henan kanbei chemical co.,ltd	58
Henan Bao Enluo International TradeCo.，LTD	58
Wuhan Haorong Biotechnology Co.,ltd	58
Zibo Hangyu Biotechnology Development Co., Ltd	58
Nantong Guangyuan Chemicl Co,Ltd	58
Henan Fengda Chemical Co., Ltd	58
Shanghai Affida new material science and technology center	58
Alpha Biopharmaceuticals Co., Ltd	58
Shanghai Daken Advanced Materials Co.,Ltd	58

107452-89-1(Ziconotide Polyacetate)Related Search:

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H-PHE-BETA-ALA-OH H-TYR-BETA-ALA-OH H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2

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OMEGA-CONOTOXIN MVIIA OMEGA-CGTX MVII A ZICONOTIDE ACETATE snx111 H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 H-CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 (DISULFIDE BRIDGE: 1-16, 8-20, AND 15-25) CYS-LYS-GLY-LYS-GLY-ALA-LYS-CYS-SER-ARG-LEU-MET-TYR-ASP-CYS-CYS-THR-GLY-SER-CYS-ARG-SER-GLY-LYS-CYS-NH2 CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (DISULFIDE BRIDGE: 1-16,8-20, AND 15-25) ω-conotoxin mviia omega-conopeptide MVIIA SNX-111, Ziconotide omega-Conopeptide MVIIA (Conus) H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2, disulfid bridges 1-16/8-20/15-25 REF DUPL: H-Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2, disulfid bridges 1-16/8-20/15-25 Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys -Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH2(Disulfide,Cys1-Cys16, Cys8-Cys20,Cys15-Cys25) Ziconotide [USAN:INN] CONOTOXIN MVII A (Omega-) o-Conotoxin MVIIA Ziconotide Zicontide Acetate L-Cysteinamide, L-cysteinyl-L-lysylglycyl-L-lysylglycyl-L-alanyl-L-lysyl-L-cysteinyl-L-seryl-L-arginyl-L-leucyl-L-methionyl-L-tyrosyl-L-α-aspartyl-L-cysteinyl-L-cysteinyl-L-threonylglycyl-L-seryl-L-cysteinyl-L-arginyl-L-serylglycyl-L-lysyl-, cyclic (1→16),(8→20),(15→25)-tris(disulfide) Ziconotide acetate USP/EP/BP ω-Conotoxin MVIIA Ziconotide Polyacetate 107452-89-1 107425-89-1 914451-03-8 C102H172N36O32S7 C102H172N36O32S7C2H4O2 Cell Biology Calcium Channel Modulators Peptide Toxins Ion Channels Voltage-gated Ion Channels Cell Signaling and Neuroscience BioChemical Peptide 107452-89-1