HEPTACHLOR
- CAS No.
- 76-44-8
- Chemical Name:
- HEPTACHLOR
- Synonyms
- Hepta;Heptachlor Standard;E3314;E3314(R);Heptachloor;1,4,5,6,7,8,8-HEPTACHLORO-3A,4,7,7A-TETRAHYDRO-4,7-METHANOINDENE;GPkh;H-34;H-60;Heptox
- CBNumber:
- CB3246285
- Molecular Formula:
- C10H5Cl7
- Molecular Weight:
- 373.32
- MOL File:
- 76-44-8.mol
- Modify Date:
- 2024/3/14 15:18:26
| Melting point | 96℃ |
|---|---|
| Boiling point | 458.95°C (rough estimate) |
| Density | 1.6 g/cm3 |
| vapor pressure | 2.33(x 10-4 mmHg) at 25 °C (subcooled liquid vapor pressure calculated from GC retention time data, Hinckleyet al., 1990) |
| refractive index | 1.5407 (estimate) |
| Flash point | 11 °C |
| storage temp. | APPROX 4°C |
| Water Solubility | 0.056 mg l-1 (25-29 °C) |
| Merck | 13,4675 |
| Henry's Law Constant | 0.19(x 10-3 atm?m3/mol) at 5 °C, 0.31 at 15 °C, 0.40 at 20 °C, 0.61 at 25 °C, 0.82 at 35 °C:in 3% NaCl solution: 0.52 at 5 °C, 0.82 at 15 °C, 1.33 at 25 °C, 2.09 at 35 °C (gas stripping-GC, Cetin et al., 2006) |
| Exposure limits | NIOSH REL: TWA 0.5 mg/m3, IDLH 35 mg/m3; OSHA PEL: TWA 0.5 mg/m3; ACGIH TLV: TWA 0.5 mg/m3. |
| Stability | Stable. Non-combustible. Incompatible with strong alkali, oxidizing agents. Corrodes many metals. |
| IARC | 2B (Vol. Sup 7, 53, 79) 2001 |
| EPA Substance Registry System | Heptachlor (76-44-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H300+H310-H351-H373-H410 |
| Precautionary statements | P202-P260-P273-P280-P301+P310-P302+P352+P310 |
| Hazard Codes | T,N,F,Xn |
| Risk Statements | 24/25-33-40-50/53-39/23/24/25-23/24/25-11-67-65-38-51/53 |
| Safety Statements | 36/37-45-60-61-62-16-7 |
| RIDADR | 2761 |
| OEB | C |
| OEL | TWA: 0.5 mg/m3 [skin] |
| WGK Germany | 3 |
| RTECS | PC0700000 |
| HazardClass | 6.1(a) |
| PackingGroup | II |
| Toxicity | LD50 in male, female rats (mg/kg): 100, 162 orally (Gaines) |
| IDLA | 35 mg/m3 |
HEPTACHLOR Chemical Properties,Uses,Production
Description
Heptachlor is a soft, white to light tan, waxy, non-combustible, crystalline solid with a camphor-like odour. Heptachlor is a member of the cyclodiene group of chlorinated insecticides (aldrin, dieldrin, endrin, chlordane, heptachlor, and endosulfan) and has a long history following World War II. It was registered as a commercial pesticide in 1952 for foliar, soil, and structure applications and for malarial control programmes; after 1960, it was used primarily in soil applications against agricultural pests and to a lesser extent against termites. Heptachlor is available commercially as a dust, a dust concentrate, an emulsifiable concentrate, a wettable powder, or in oil solutions. It is corrosive to metals and reacts with iron and rust to form hydrogen chloride gas. Heptachlor is incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides but is stable under normal temperatures and pressures. It may burn, but does not ignite readily. Heptachlor at high heat and temperature produces highly toxic, corrosive fumes of hydrogen chlorine gas and toxic oxides of carbon. An important metabolite of heptachlor is heptachlor epoxide which is an oxidation product formed from heptachlor by many plant and animal species. Heptachlor is almost insoluble in water but soluble in ether, acetone, benzene, and many other organic solvents.
Chemical Properties
Heptachlor is an organochlorine cyclodiene insecticide isolated from technical chlordane. It is available in the form of white crystals or a tan-colored waxy solid with a characteris- tic camphor-like or cedar-like odor. It is sparingly soluble or insoluble in water, but fairly soluble in acetone, benzene, ethanol, xylene, and other organic solvents. It is used for the control of termites, ants, and soil insects in cultivated and non-cultivated soils. Heptachlor epoxide is formed in nature when heptachlor is released into the environment and mixes with oxygen. Heptachlor epoxide remains in the soil for long periods of time. Heptachlor and heptachlor epoxide may also be present at numerous hazardous waste sites. Although the use of heptachlor is restricted, exposure to the general population does occur through the ingestion of contaminated food.
Physical properties
Colorless to light tan, waxy or crystalline, nonflammable solid with a camphor-like odor
Uses
Heptachlor is used for the control of termites, ants, household insects and soil insects. It is also applied as a seed treatment, soil treatment or directly to foliage.
Preparation
Heptachlor may be synthesized by reacting chlordene with N-bromosuccinimide to give the intermediate 1-bromochlordene followed by chlorination with hydrogen chloride in nitromethane in the presence of aluminum trichloride.
Definition
ChEBI: A cyclodiene organochlorine insecticide that is 3a,4,7,7a-tetrahydro-1H-4,7-methanoindene substituted by chlorine atoms at positions 1, 4, 5, 6, 7, 8 and 8. Formerly used to kill termites, ants and other insects in agricultural and domes ic situations.
General Description
HEPTACHLOR is a white to light tan waxy looking solid. Noncombustible. Insoluble in water. Can cause illness by inhalation, skin absorption and/or ingestion. The primary hazard is the threat posed to the environment. Immediate steps should be taken to limit its spread to the environment. Used as an insecticide.
Air & Water Reactions
Susceptible to epoxidation. Insoluble in water. Slowly losses hydrogen chloride in the presence of alkaline solution.
Reactivity Profile
HEPTACHLOR is incompatible with strong alkalis. Corrosive to metals. Can react with iron and rust to form toxic gases. Can react vigorously with oxidizing materials. Susceptible to epoxidation . May be incompatible with many amines, nitrides, azo/diazo compounds, alkali metals, and epoxides.
Hazard
Toxic by ingestion, inhalation, and skin absorption; use has been restricted and discontinued except for termite control. Possible carcinogen.
Health Hazard
Exposures to heptachlor epoxide cause adverse health effects to animals and humans. Exposure to heptachlor is toxic by mouth, by skin contact, as well as by inhalation of dust from powder concentrates. Heptachlor acts as a CNS stimulant. Prolonged period of expo- sures to high concentrations of heptachlor cause headache, dizziness, nausea, vomiting, weakness, irritability, salivation, lethargy, respiration distress, muscle tremors, convul- sions, and paralysis. Severe cases of poisoning lead to respiratory failure and death. In fact, seizures and cortical excitability are the prime CNS symptoms following acute hepta- chlor exposure. The photoisomer of heptachlor (photoheptachlor) and the major metabo- lite of heptachlor, namely, heptachlor epoxide are more toxic than the parent compound. Heptachlor induces tremors, convulsions, paralysis, and hypothermia in rats and young calves. The poisoned animals showed muscle spasms in the head and neck region, convul- sive seizures, elevated body temperatures, and engorged brain blood vessels. Humans exposed to heptachlor in the home during termite control operations showed signs of neurotoxicity, i.e., irritability, salivation, lethargy, dizziness, labored respiration, muscle tremors, convulsions, and death due to respiratory failure. Heptachlor interfered with nerve transmission, caused hyperexcitation of the CNS, lethargy, incoordination, tremors, convulsions, stomach cramps or pain, leading to coma and death.
Fire Hazard
Special Hazards of Combustion Products: Irritating hydrogen chloride fumes may form in fire.
Metabolic pathway
Heptachlor is quite stable and resistant to environmental degradation. Metabolic processes by which it undergoes transformation are epoxidation, hydrolysis and dechlorination. It is transformed into a variety of products, many of which differ from one another only in stereochemical features while retaining the carbon skeleton and the chlorinated norbornene moiety. The main biological metabolite is exoepoxyheptachlor. Products formed by sensitised photolysis have caged structures and undergo reactions that are typical of this class.
HEPTACHLOR Preparation Products And Raw materials
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