Daclatasvir Dihydrochloride

CAS No.: 1009119-65-6

Chemical Name:: Daclatasvir Dihydrochloride

Synonyms: BMS 790052;Declatasvir;BMS790052 HCl;Daclatasvir API;BMS-790052 2HCl;Daclatasvir HCL;DACLATASVIR(2HCl);Daclatasvir DiHCl;Daclatasvir/Daklinza;BMS 790052 (di HClsalt)

CBNumber:: CB32514542

Molecular Formula:: C40H51ClN8O6

Molecular Weight:: 775.35

MOL File:: 1009119-65-6.mol

Modify Date:: 2023/5/18 11:31:01

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Daclatasvir Dihydrochloride Properties

Melting point	>207°C (dec.)
storage temp.	-20°C Freezer
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
color	Off-White to Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07,GHS08
Signal word	Warning
Hazard statements	H317-H373-H335-H319
Precautionary statements	P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P260-P314-P501-P264-P280-P305+P351+P338-P337+P313P

Daclatasvir Dihydrochloride Chemical Properties,Uses,Production

Description

Daclatasvir dihydrochloride is a hepatitis C virus nonstructural 5A (NS5A) replication complex inhibitor which was first approved in Japan for the treatment of genotype 1 HCV patients who fail to respond to interferon plus ribavirin. The drug has also been approved for patients with untreated, chronic HCV who are eligible for interferon. Additionally, in Europe, daclatasvir was approved for use in combination with other products across genotype 1–4 HCV. Daclatasvir was discovered and developed by Bristol–Myers Squibb and a fascinating account describing the initiation of the program from a phenotypic screen and the medicinal chemistry strategy leading to the discovery of the compound has been recently reported.

Chemical Properties

Daclatasvir dihydrochloride is white to yellow powder. It is freely soluble in water (>700 mg/mL). The solubility is strongly pH-dependent and the solubility is high at low pH values.

Uses

Daclatasvir Dihydrochloride is the dihydrochloride salt form of daclatasvir, an orally available inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A) replication complex, with potential activity against HCV. Daclatasvir is used with another antiviral medication (sofosbuvir) to treat chronic (long-lasting) hepatitis C, a viral infection of the liver. Daclatasvir should never be used without sofosbuvir. Daclatasvir and sofosbuvir may also be used with another antiviral medication (ribavirin).

Definition

ChEBI: Daclatasvir hydrochloride is a hydrochloride obtained by combining daclatasvir with two molar equivalents of hydrochloric acid. It is a potent inhibitor of nonstructural protein 5A and is used for treatment of hepatitis C. It has a role as an antiviral drug and a nonstructural protein 5A inhibitor. It contains a daclatasvir(2+).

Mode of action

Daclatasvir is an inhibitor of nonstructural protein 5A (NS5A), a multifunctional protein that is an essential component of the HCV replication complex. Daclatasvir binds to the N-terminus of NS5A and inhibits both viral RNA replication and virion assembly.

Daclatasvir Dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Daclatasvir Dihydrochloride Suppliers

Global( 282)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Jigs Chemical ltd	+919099003427	Gujarat, India	239	58	Inquiry
Bulat Pharmaceutical Pvt Ltd	+91-8448085659 +91-8448085660	Haryana, India	123	58	Inquiry
Viruj Pharmaceuticals Pvt Ltd	+91-9441591589 +91-9441591589	Hyderabad, India	33	58	Inquiry
Glenmark Pharmaceuticals Limited	+912240189999	Maharashtra, India	93	58	Inquiry
Hetero Drugs Limited	+91-4023704923 +91-4023704923	Telangana, India	296	58	Inquiry
VIVIN DRUGS AND PHARMACEUTICALS LTD	+91-22670456625 +91-224067045635	Telangana, India	22	58	Inquiry
Arene Lifesciences Limited	+91-9849847907 +91-8455241148	Telangana, India	55	58	Inquiry
Mylan Laboratories Ltd	+91-4023550543 +91-4030866666	Telangana, India	150	58	Inquiry
AKASH PHARMA EXPORTS	+91-9388123451 +91-9846039283	Kerela, India	470	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6761	58	Inquiry

Supplier	Advantage
Jigs Chemical ltd	58
Bulat Pharmaceutical Pvt Ltd	58
Viruj Pharmaceuticals Pvt Ltd	58
Glenmark Pharmaceuticals Limited	58
Hetero Drugs Limited	58
VIVIN DRUGS AND PHARMACEUTICALS LTD	58
Arene Lifesciences Limited	58
Mylan Laboratories Ltd	58
AKASH PHARMA EXPORTS	58
Pharma Affiliates	58

Daclatasvir Dihydrochloride Spectrum

Daclatasvir Dihydrochloride(1009119-65-6)¹HNMR

1009119-65-6(Daclatasvir Dihydrochloride)Related Search:

Daclatasvir tadalafi methyl ((S)-1-((S)-2-(5-(4'-(2-((S)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-yl)-1H-imidazol-4-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate Daclatasvir Impurity 5 (SRSS-Isomer) Daclatasvir Impurity F

Daclatasvir Impurity 1-{4'-acetyl-[1,1'-biphenyl]-4-yl}-2-bromoethan-1-one Daclatasvir Impurity 7 1,1'-[1,1'-biphenyl]-4,4'-diylbis[2,2-dibromo]-ethanone

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BMS 790052 N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride Daclatasvir`Daclatasvir dihydrochloride Dclatasvir dihydrochloride Daclatasvir Digydrochloride Carbamic acid, N,N'-[[1,1'-biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]bis-, C,C'-dimethyl ester, hydrochloride (1:2) Daclatasvir API Dackatasvir dihydrochloride daclatasvir hydrochloride BMS-790052 (dihydrochloride) BMS790052 HCl Daclatasvir dihydrochloride BMS-790052 2HCl DACLATASVIR(2HCl) Daclatasvir HCL Methyl (1-((2S)-2-(5-(4'-(2-(1-((methoxycarbonyl)valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate hydrochloride Daclatasivir Dihydrochloride Daclatasvir/Daklinza dimethyl ((2S,2'S)-((2S,2'S)-2,2'-(5,5'-([1,1'-biphenyl]-4,4'-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate Daclatasvir dihydrochloride, >=98% BMS-790052;BMS790052 ;BMS 790052;DACLATASVIR;BMS-790052 DIHYDROCHLORIDE;BMS790052 DIHYDROCHLORIDE;BMS 790052 DIHYDROCHLORIDE BMS-790052; BMS790052 ; BMS 790052;DACLATASVIR Daclatasvir dihydrochloride (BMS-790052) BMS 790052 (di HClsalt) N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)- Daclatasvir dihydrochloride (BMS-790052 dihydrochloride) Dacatavir dihydrochloride Daclatavir Dihydrochloride Daclatasvir DiHCl N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride USP/EP/BP Daclatasvir dihydrochlorid methyl N-[(2S)-1-[(2S)-2-[5-(4'-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-5-yl}-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl]pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate dihydrochloride TIANFU CHEM---N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride Daclatasvir dihydrochloride(BMS-790052) Competitive price/Top quality Methyl ((S)-1-((S)-2-(5-(4'-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate dihydrochloride Declatasvir Daclatasvir Hcl In-House methyl N-[(2S)-1-[(2S)-2-{4-[4-(4-{2-[(2S)-1-[(2S)-2-[(methoxycarbonyl)amino]-3-methylbutanoyl]pyrrolidin-2-yl]-1H-imidazol-4-yl}phenyl)phenyl]-1H-imidazol-2-yl}pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]carbamate.dihydrochloride Methyl ((S)-1-((S)-2-(5-(4'-(2-((S)-1-((methoxycarbonyl)-L-valyl)pyrrolidin-2-yl)-1H-imidazol-5-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate dihydrochloride N,N'-[[1,1'-Biphenyl]-4,4'-diylbis[1H-imidazole-5,2-diyl-(2S)-2,1-pyrrolidinediyl[(1S)-1-(1-methylethyl)-2-oxo-2,1-ethanediyl]]]biscarbamic acid dimethyl ester hydrochloride dimethyl ((2S,2'S)-((2S,2'S)-2,2'-(5,5'-([1,1'-biphenyl]-4,4'-diyl)bis(1H-imidazole-5,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate hydrochloride dimethyl ((2S,2'S)-((2S,2'S)-2,2'-(4,4'-([1,1'-biphenyl]-4,4'-diyl)bis(1H-imidazole-4,2-diyl))bis(pyrrolidine-2,1-diyl))bis(3-methyl-1-oxobutane-2,1-diyl))dicarbamate dihydrochloride 1009119-65-6 C40H52Cl2N8O6 C40H50N8O62HCl C40H50N8O62ClH Inhibitors