CefepiMe interMediate (7-PIME)

CefepiMe interMediate (7-PIME) Structure
CAS No.
103121-85-3
Chemical Name:
CefepiMe interMediate (7-PIME)
Synonyms
7-PIME;1-[[(6R,7R)-7-AMino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]Methyl]-1-MethylpyrrolidiniuM Chloride;CEFEPIME USP RC E;Cefepime EP Impurity E;Cefepime parent nucleus;Cefepime mother nucleus;Cefepime amine derivative;Cefepime EP Impurity E HCl;Cefepime amine derivatives;CefepiMe Related CoMpound E
CBNumber:
CB32663756
Molecular Formula:
C13H20ClN3O3S
Molecular Weight:
333.8342
MOL File:
103121-85-3.mol
MSDS File:
SDS
Modify Date:
2023/5/4 15:16:18

CefepiMe interMediate (7-PIME) Properties

Melting point >150°C (dec.)
Boiling point 681℃[at 101 325 Pa]
Density 1.61[at 20℃]
vapor pressure 0Pa at 25℃
storage temp. Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly)
form Solid
color Off-White to Pale Beige
Water Solubility 111g/L at 20℃
Stability Very Hygroscopic
LogP -3.35 at 20℃

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H319-H335-H302-H315
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
HS Code  2941906000

CefepiMe interMediate (7-PIME) Chemical Properties,Uses,Production

Uses

1-[[(6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methylpyrrolidinium Chloride is an impurity in the synthesis of Cefepime (C242750), a semisynthetic, fourth generation cephalosporin antibiotic. Antibacterial.

CefepiMe interMediate (7-PIME) Preparation Products And Raw materials

Raw materials

Preparation Products

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CefepiMe interMediate (7-PIME) CefepiMe Related CoMpound E Cefepime Related Compound E (20 mg) (1-{[(6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl}-1-methylpyrrolidin-1-ium chloride) Cefepime EP Impurity E Cefepime EP Impurity E HCl (6R,7R)-7-Amino-3-[(1-methyl-1-pyrrolidiniumyl)methyl]-8-oxo-5-th ia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride (1:1) (6R,7R)-7-Amino-3-[(1-methyl-1-pyrrolidiniumyl)methyl]-8-oxo-5-th ia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate hydrochloride (1:1) Cefepime amine derivative Cefepime EP Impurity E/ Cefepime Related Compound E (6R,7R)-7-amino-3-[(1-methylpyrrolidinium-1-yl)methyl]-8-oxo... Cefepime Related Compound E (1-{[(6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en (1097691) 1-[[(6R,7R)-7-AMino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]Methyl]-1-MethylpyrrolidiniuM Chloride 7-PIME 1-(((6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl)methyl)-1-methylpyrrolidin-1-ium chloride Cefepime parent nucleus Cefepime EP Impurity E Chloride (Cefepime USP Related Compound E) Cefepime mother nucleus CEFEPIME USP RC E Cefepime amine derivatives 103121-85-3 C13H20N3O3SCl Chiral Reagents, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds