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AMG 925

AMG 925 Structure
CAS No.
1401033-86-0
Chemical Name:
AMG 925
Synonyms
FLX925;FLX-925;AMG 925;CS-1594;FLX 925.;AMG 925 (FLX925;FLX925 (AMG-925);AMG 925;AMG925;AMG-925;AMG925; AMG-925; AMG 925; FLX925; FLX-925; FLX 925.;2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-
CBNumber:
CB32685918
Molecular Formula:
C26H29N7O2
Molecular Weight:
471.55
MOL File:
1401033-86-0.mol
MSDS File:
SDS
Modify Date:
2024/7/2 8:55:06
Request For Quotation

AMG 925 Properties

Boiling point 712.3±70.0 °C(Predicted)
Density 1.48±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in DMSO; insoluble in H2O; insoluble in EtOH
form solid
pka 13.41±0.10(Predicted)
color Light yellow to yellow

AMG 925 Chemical Properties,Uses,Production

Description

AMG 925 is a dual inhibitor of FMS-related tyrosine kinase 3 (FLT3) and cyclin-dependent kinase 4 (Cdk4; IC50s = 1 and 3 nM, respectively). It is selective for FLT3 and Cdk4 over Cdk1 (IC50 = 2.22 μM). AMG 925 also binds to FLT3ITD, FLT3D835Y, FLT3D835H, FLT3K663Q, and FLT3N841I (Kds = 1-4 nM). It inhibits proliferation of MOLM-13, COLO 205, and U937 cancer cells (IC50s = 19, 55, and 52 nM, respectively). AMG 925 (50, 75, and 150 mg/kg) reduces intratumor levels of pSTAT5 and pRb and inhibits tumor growth in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model.

AMG 925 Preparation Products And Raw materials

Raw materials

2,4-Pyrimidinediamine, N4-(trans-4-methylcyclohexyl)- 1401033-82-6 2,4-Pyrimidinediamine, 5-iodo-N4-(trans-4-methylcyclohexyl)- 9H-Pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine, 9-(trans-4-methylcyclohexyl)- 2-methylpropan-2-yl 2-({9-[(1r,4r)-4-methylcyclohexyl]pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-5,6,7,8-tetrahydropyrido[4,3-b]pyridine-6-carboxylate
trans-4-Methylcyclohexyl amine tert-butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate trans-4-Methylcyclohexylamine hydrochloride 2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE Glycolic acid
3-Fluoropyridine
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Preparation Products

AMG 925 Suppliers

Global( 61)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
TargetMol Chemicals Inc. +1-781-999-5354 United States 19973 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Matrix Scientific 803 788-9494 All other calls United States 6655 80 Inquiry
Taizhou Crene Biotechnology Co. Ltd. +86-0576-88813233 +86-13396860566 China 1990 58 Inquiry
United States Biological 1-800-520-3011 United States 6106 58 Inquiry
ApexBio Technology + 1-832-696-8203 United States 6254 58 Inquiry
Absin Bioscience Inc. 021-38015121 15000105423 China 24734 58 Inquiry
Supplier Advantage
BOC Sciences 58
InvivoChem 58
TargetMol Chemicals Inc. 58
Aladdin Scientific 58
Amadis Chemical Company Limited 58
Matrix Scientific 80
Taizhou Crene Biotechnology Co. Ltd. 58
United States Biological 58
ApexBio Technology 58
Absin Bioscience Inc. 58

AMG 925 Spectrum

AMG 925(1401033-86-0)1HNMR
AMG 925 1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone 2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2- Ethanone, 1-[7,8-dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxy- AMG 925;AMG925;AMG-925 CS-1594 2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone AMG925; AMG-925; AMG 925; FLX925; FLX-925; FLX 925. FLX 925. FLX925 FLX-925 AMG 925 (FLX925 FLX925 (AMG-925) CDK,AMG 925,Cluster of differentiation antigen 135,FLT3,Cyclin dependent kinase,inhibit,CD135,AMG-925,AMG925,Inhibitor,Fms like tyrosine kinase 3 1401033-86-0 C26H29N7O2