ChemicalBook >제품 카탈로그 >AMG 925

AMG 925

AMG 925 구조식 이미지

카스 번호:: 1401033-86-0

상품명:: AMG 925

동의어(영문):: FLX925;FLX-925;AMG 925;CS-1594;FLX 925.;AMG 925 (FLX925;FLX925 (AMG-925);AMG 925;AMG925;AMG-925;AMG925; AMG-925; AMG 925; FLX925; FLX-925; FLX 925.;2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-

CBNumber:: CB32685918

분자식:: C26H29N7O2

포뮬러 무게:: 471.55

MOL 파일:: 1401033-86-0.mol

속성

안전

용도

공급 업체 61

AMG 925 속성

끓는 점: 712.3±70.0 °C(Predicted)

밀도: 1.48±0.1 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: insoluble in DMSO; insoluble in H2O; insoluble in EtOH

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): 13.41±0.10(Predicted)

색상: Light yellow to yellow

안전

AMG 925 C화학적 특성, 용도, 생산

개요

AMG 925 is a dual inhibitor of FMS-related tyrosine kinase 3 (FLT3) and cyclin-dependent kinase 4 (Cdk4; IC₅₀s = 1 and 3 nM, respectively). It is selective for FLT3 and Cdk4 over Cdk1 (IC₅₀ = 2.22 μM). AMG 925 also binds to FLT3^ITD, FLT3^D835Y, FLT3^D835H, FLT3^K663Q, and FLT3^N841I (K_ds = 1-4 nM). It inhibits proliferation of MOLM-13, COLO 205, and U937 cancer cells (IC₅₀s = 19, 55, and 52 nM, respectively). AMG 925 (50, 75, and 150 mg/kg) reduces intratumor levels of pSTAT5 and pRb and inhibits tumor growth in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model.

AMG 925 준비 용품 및 원자재

원자재

2,4-Pyrimidinediamine, N4-(trans-4-methylcyclohexyl)- 1401033-82-6 2,4-Pyrimidinediamine, 5-iodo-N4-(trans-4-methylcyclohexyl)- 9H-Pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine, 9-(trans-4-methylcyclohexyl)- AMG-925 Intermediate 트랜스-4-메틸사이클로헥실아민 tert-butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate 트랜스-4-메틸시클로헥실아민염산염 2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-나프티리딘염화물 글리콜산 플로로피리딘

준비 용품

AMG 925 공급 업체

글로벌( 61)공급 업체

공급자	전화	이메일	국가	제품 수	이점
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57511	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131980	58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.	17702719238 17702719238	sales@sun-shinechem.com	China	915	64
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4663	58
Shanghai Topbiochem Technology Co., Ltd	021-58170097	info@topbiochem.com	China	9461	58
Haoyuan Chemexpress Co., Ltd.	021-58950125	info@chemexpress.com	China	7553	61
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2784	58