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DE-7

DE-7 Structure
CAS No.
681490-93-7
Chemical Name:
DE-7
Synonyms
DE-7;Dilamanid intermediate;2-Chloro-1-[[(2R)-2-methyloxiranyl]methyl]-4-nitro-1H-imidazole;(R)-2-chloro-1-{(2-methyloxiran-2-yl)methyl}-4-nitro-1H-imidazole;1H-Imidazole, 2-chloro-1-[[(2R)-2-methyl-2-oxiranyl]methyl]-4-nitro-
CBNumber:
CB33154114
Molecular Formula:
C7H8ClN3O3
Molecular Weight:
217.61
MOL File:
681490-93-7.mol
MSDS File:
SDS
Modify Date:
2023/4/23 13:52:06
Request For Quotation

DE-7 Properties

Melting point 72-73 °C
Boiling point 393.9±38.0 °C(Predicted)
Density 1.68±0.1 g/cm3(Predicted)
solubility Chloroform, DCM
form Solid
pka -2.55±0.60(Predicted)
color Off-White

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07,GHS08
Signal word  Danger
Hazard statements  H312-H303-H315-H319-H361-H372-H317-H351-H335-H336-H412
Precautionary statements  P501-P273-P272-P260-P270-P202-P201-P271-P264-P280-P312-P337+P313-P305+P351+P338-P362+P364-P333+P313-P302+P352+P312-P304+P340+P312-P403+P233-P405

DE-7 Chemical Properties,Uses,Production

Uses

2-Chloro-1-[[(2R)-2-methyloxiranyl]methyl]-4-nitro-1H-imidazole is an intermediate in the synthesis of Delamanid (D230660), a novel anti-tuberculosis medication that inhibits mycolic acid synthesis and shows potent in-vitro and in-vivo activity against drug-resistant strains of Mycobacterium tuberculosis.

DE-7 Preparation Products And Raw materials

Raw materials

2-Chloro-4-nitroimidazole DE-6 (R)-3-(2-chloro-4-nitro-1H-imidazol-1-yl)-2-hydroxy-2-methylpropylmethanesulfonate (R)-2-chloro-1-(2,3-dihydroxy-2-methyl)-propyl-4-nitroimidazole (R)-2-chloro-1-[2-hydroxy-2-methyl-3-(4-nitrobenzoyloxy)]-propyl-4-nitroimidazole

Preparation Products

DE-7 Suppliers

Global( 17)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CD Chemical Group Limited +8615986615575 China 20356 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Zhengzhou Acme Chemical Co., Ltd. 0371-0371-63315541 13323832564 China 9909 58 Inquiry
Lynnchem 86-(0)29-85992781 17792393971 China 4587 58 Inquiry
Aikon International Limited 18626450290 China 10718 58 Inquiry
Changzhou Yanji Biotechnology Co., Ltd. 0519-83556355 18015005120 China 3785 55 Inquiry
Chemipanda Bio-Tech Co., Ltd. +86-571-85224801; 13588483690 China 104 62 Inquiry
Bide Pharmatech Ltd. 400-6005915 China 39668 58 Inquiry
Suzhou Meishi Biotechnology Co., Ltd. 1173954148q China 20035 58 Inquiry
Hangzhou Hua Zhe Biological Medicine Co., LTD 0571-5683-8096 17302275155 China 98 58 Inquiry
Supplier Advantage
CD Chemical Group Limited 58
Amadis Chemical Company Limited 58
Zhengzhou Acme Chemical Co., Ltd. 58
Lynnchem 58
Aikon International Limited 58
Changzhou Yanji Biotechnology Co., Ltd. 55
Chemipanda Bio-Tech Co., Ltd. 62
Bide Pharmatech Ltd. 58
Suzhou Meishi Biotechnology Co., Ltd. 58
Hangzhou Hua Zhe Biological Medicine Co., LTD 58
DE-7 (R)-2-chloro-1-{(2-methyloxiran-2-yl)methyl}-4-nitro-1H-imidazole 2-Chloro-1-[[(2R)-2-methyloxiranyl]methyl]-4-nitro-1H-imidazole Dilamanid intermediate 1H-Imidazole, 2-chloro-1-[[(2R)-2-methyl-2-oxiranyl]methyl]-4-nitro- 681490-93-7