ChemicalBook > Product Catalog >Chemical Reagents >Organic reagents >Thiol / thiol >DL-Dithiothreitol
DL-Dithiothreitol
- CAS No.
- 27565-41-9
- Chemical Name:
- DL-Dithiothreitol
- Synonyms
- DTT;1,4-DITHIOTHREITOL;1,4-DITHIO-DL-THREITOL;Cleland's reagent;DTT-MBG;DITHIOTHRIETOL;(2R,3R)-1,4-dimercaptobutane-2,3-diol;DITT;DL-DTT;CGMP DTT
- CBNumber:
- CB3342918
- Molecular Formula:
- C4H10O2S2
- Molecular Weight:
- 154.25
- MOL File:
- 27565-41-9.mol
- Modify Date:
- 2024/3/26 17:16:27
| Melting point | 41-44 °C(lit.) |
|---|---|
| Boiling point | 125-130 °C (2 mmHg) |
| Density | 1.04 g/mL at 20 °C |
| refractive index | 1.5200 (estimate) |
| Flash point | >230 °F |
| storage temp. | 2-8°C |
| solubility | H2O: 50 mg/mL, clear, colorless |
| form | Liquid |
| color | White |
| Water Solubility | Soluble |
| Merck | 3376 |
| CAS DataBase Reference | 27565-41-9(CAS DataBase Reference) |
| EPA Substance Registry System | 2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-rel-(27565-41-9) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H319-H302-H335-H315 |
| Precautionary statements | P264-P270-P301+P312-P330-P501-P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P |
| Hazard Codes | Xn |
| Risk Statements | 25-36/37/38-22 |
| Safety Statements | 26-45-36 |
| WGK Germany | 3 |
| RTECS | EK1610000 |
| F | 3-10-16-23 |
| HS Code | 29309090 |
| Toxicity | mouse,LD50,intramuscular,108mg/kg (108mg/kg),BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Journal of Pharmacy and Pharmacology. Vol. 1, Pg. 576, 1949. |
DL-Dithiothreitol Chemical Properties,Uses,Production
Chemical Properties
White solid
Uses
Reagent for the quantitative reduction of disulfide group. Prevents the oxidation of cholecystokinin during its extraction from brain and duodenal tissues. Cleavage of disulfide bonds in proteins.
Preparation
The preparation of DL-Dithiothreitol is as follows:To a round bottom flask was charged THPP (23mg, 0.11mmol, 1.10eq) and the basic buffer solution [tris-(hydroxymethyl)-aminomethane-CaCl2 based buffer; pH 8.00; 1.0mL]. The reaction mixture was stirred at room temperature for about 5 min and then to this homogenous solution was charged trans-4,5-Dihydroxy-1,2-dithiane (15.2mg, 0.10 mmol, 1.00eq.). The reaction mixture was stirred at room temperature until the reaction was complete (about 30 min). The product was readily identified by 1H-NMR analysis.
Purification Methods
Crystallise DTT from ether and sublime it at 37o/0.005mm. It should be stored at 0o. [Beilstein 1 III 2360.]
DL-Dithiothreitol Preparation Products And Raw materials
Global( 239)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| Jiangsu Boquan Biotechnology Co., Ltd. | +86-18168774353 | China | 248 | 58 | Inquiry |
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | China | 12456 | 58 | Inquiry |
| hebei hongtan Biotechnology Co., Ltd | +86-86-1913198-3935 +8617331935328 | China | 973 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29898 | 58 | Inquiry |
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | China | 7513 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | China | 13164 | 58 | Inquiry |
| Hebei Yanxi Chemical Co., Ltd. | +86-17531190177; +8617531190177 | China | 5873 | 58 | Inquiry |
27565-41-9(DL-Dithiothreitol)Related Search:
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DTT (RACEMIC)
DL-THREO-2,3-DIHYDROXY-1,4-DITHIOLBUTANE
DL-THREO-1,4-DIMERCAPTO-2,3-BUTANEDIOL
DL-DTT
DITHIOTHREITOL, 1,4-
DITT
DL-2,3-DIHYDROXY-1,4-BUTANEDITHIOL
DL-1,4-DIMERCAPTO-2,3-BUTANEDIOL
CGMP DTT
CLELAND REAGENT RACEMIC
CLELAND'S REAGENT, IMMOBILIZED
CLELAND'S REDUCTACRYL(TM) REAGENT
2,3-BUTANEDIOL, 1,4-DIMERCAPTO-(R*,R*)-
(2S,3S:2R,3R)-THREO-1,4-DIMERCAPTO-2,3-BUTANEDIOL
1,4-DITHIOTHREITHOL
RAC-CLELAND'S REAGENT
(R,R)-DITHIOTHREITOL
(R,R)-1,4-DIMERCAPTO-2,3-BUTANEDIOL
THREO-2,3-DIHYDROXY-1,4-DITHIOBUTANE
THREO-2,3-DIHYDROXY-1,4-DITHIOLBUTANE
SPUTOLYSIN(R) REAGENT
1,4-dimercapto-,(r*,r*)-(+-)-3-butanediol
1,4-dimercapto-,(theta,theta)-(+/-)-3-butanediol
4-dimercapto-3-butanediodl-threo-1
4-dithio-dl-threito
rac-dithiothreitol
1 4-DITHIO-DL-THREITOL(+4℃)
Di-dithiothreitol
DTT(1,4-Dithiothreitol
1,4-Dithio-DL-threitol≥ 99% (Titration)
1,4-dithio-dl-threitol sol.
Clelands REDUCTACRYL
dithiothreitol (dtt) sequencing grade
dithiothreitol molecular biology*reagent
DithiothreitollelandsReagenz
Dithithreitol
DL-Dithothreitol
(R*,R*)-(±)-1,4-dimercaptobutane-2,3-diol
2,3-BUTANEDIOL, 1,4-DIMERCAPTO-(R*,R*)-()-OR,DITHIOTHREITOL
Dtt(Dl-Dithiothreitol)
(±)-1,4-Dithiothreitol-D6
DL-DITHIOTHREITOL,ELECTROPHORESISGRADE
(+/-)-1,4-Dithio-D-threitol
D-Dithiothreitol, (2S,3S)-threo-1,4-Dimercapto-2,3-butandiol
DL-DITHIOTHREITOL extrapure
2,3-Butanediol, 1,4-dimercapto-, (2R,3R)-
DL-1,4-Dimercapto-2,3-dihydroxybutane
threo-2,3-Dihydroxy-1,4-butanedithiol
DL-Dithiothreitol [for Electrophoresis]
DL-1,4-Dithiothreitol ,98%
DITHIOTHREITOL RESEARCH GRADE
Dithiothreitol in Ethyl acetate@1000 μg/mL in Ethyl acetate
DTT-MBG
DITHIOTHRIETOL
1,4-DITHIO-DL-THREITOL
1,4-DITHIOTHREITOL
(2R,3R)-1,4-dimercaptobutane-2,3-diol
Cleland's reagent