2,2'-Dithiosalicylic acid

- CAS No.
- 119-80-2
- Chemical Name:
- 2,2'-Dithiosalicylic acid
- Synonyms
- DSTA;DITHIOSALICYLIC ACID;2,2'-disulfanediyldibenzoic acid;NSC 213;NSC 5346;NSC 405662;NSC 633230;AKOS AUF01570;Dithioslicylicacid;2,2'-Dithiodibenzoic
- CBNumber:
- CB1420317
- Molecular Formula:
- C14H10O4S2
- Molecular Weight:
- 306.36
- MOL File:
- 119-80-2.mol
- MSDS File:
- SDS
- Modify Date:
- 2025/1/27 9:38:02
Melting point | 287-290 °C(lit.) |
---|---|
Boiling point | 416.97°C (rough estimate) |
Density | 1.4555 (rough estimate) |
vapor pressure | 0Pa at 25℃ |
refractive index | 1.4950 (estimate) |
storage temp. | Refrigerator |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 3.02±0.36(Predicted) |
form | Powder |
color | Brown |
Water Solubility | insoluble |
BRN | 2221810 |
InChIKey | LBEMXJWGHIEXRA-UHFFFAOYSA-N |
LogP | 1.61 at 25℃ and pH6.2-6.48 |
CAS DataBase Reference | 119-80-2(CAS DataBase Reference) |
EPA Substance Registry System | Benzoic acid, 2,2'-dithiobis- (119-80-2) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H315-H319-H335 | |||||||||
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313 | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36-24/25 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | DG9660000 | |||||||||
Hazard Note | Harmful/irritant | |||||||||
TSCA | Yes | |||||||||
HS Code | 29309070 | |||||||||
Toxicity | LD50 ipr-mus: 367 mg/kg ARZNAD 21,284,71 | |||||||||
NFPA 704 |
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2,2'-Dithiosalicylic acid price More Price(7)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich(India) | PHR2590 | Thimerosal Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material | 119-80-2 | 100MG | ₹45529.95 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 43761 | 2,2′-Dithiodibenzoic acid ≥95.0% (NT) | 119-80-2 | 100G | ₹3279.98 | 2022-06-14 | Buy |
TCI Chemicals (India) | D1437 | 2,2'-Dithiodibenzoic Acid | 119-80-2 | 25G | ₹4200 | 2022-05-26 | Buy |
TCI Chemicals (India) | D1437 | 2,2'-Dithiodibenzoic Acid | 119-80-2 | 100G | ₹9800 | 2022-05-26 | Buy |
TCI Chemicals (India) | D1437 | 2,2'-Dithiodibenzoic Acid | 119-80-2 | 500G | ₹33200 | 2022-05-26 | Buy |
2,2'-Dithiosalicylic acid Chemical Properties,Uses,Production
Chemical Properties
brown powder
Uses
2,2'-Dithiosalicylic acid is an organosulfur compound produced from dibenzothiophene metabolites that is in turn biodegraded into transient metabolites such as benzoic acid.It is used in the preparation of a new class of anti-HIV-1 agents.
General Description
2,2′-Dithiodibenzoic acid is an sulfhydryl modifying reagent. 2,2′-Dithiodibenzoic acid on cocrystallization with imidazole or 4-methylimidazole affords bis(imidazolium) 2,2′-dithiodibenzoate and 4-methylimidazolium 2-[(2-carboxyphenyl)disulfanyl]benzoate organic salt, respectively. It also cocrystallizes with isonicotinohydrazide from methanol solution to afford the 1:2 cocrystal, 2,2′-dithiodibenzoic acid-isonicotinohydrazide.
Safety Profile
Poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofSOx.
Synthesis
A preparation method of 2,2'-dithiosalicylic acid is as follows: using anthranilic acid as raw material and performing a diazotization reaction with sodium nitrite and hydrochloric acid at 0 to 10°C to obtain a diazo liquid. The liquid reacts with liquid sulfur dioxide for 0.5 to 3 hours in the presence of a catalyst and a cocatalyst at -20~~-10°C and then is kept at 80~100°C for 0.5~2 hours, cooled, and filtered to obtain 2,2'-Dithiosalicylic acid.
2,2'-Dithiosalicylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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GLR Innovations | 58 |
PARAGON FINE AND SPECIALITY CHEMICAL PVT LTD | 58 |
Vasant Chemicals Pvt Ltd | 58 |
Shreyaa Medilife Private Limited | 58 |
Reax Chemicals | 58 |
Prashant Dyechem | 58 |
HiMedia Laboratories | 58 |
Ambuja Intermediates Private Limited | 58 |
Clearsynth Labs | 58 |
Colour Finders | 58 |
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