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2,2'-Dithiosalicylic acid

2,2'-Dithiosalicylic acid Structure
CAS No.
119-80-2
Chemical Name:
2,2'-Dithiosalicylic acid
Synonyms
DSTA;DITHIOSALICYLIC ACID;2,2'-disulfanediyldibenzoic acid;NSC 213;NSC 5346;NSC 405662;NSC 633230;AKOS AUF01570;Dithioslicylicacid;2,2'-Dithiodibenzoic
CBNumber:
CB1420317
Molecular Formula:
C14H10O4S2
Molecular Weight:
306.36
MOL File:
119-80-2.mol
MSDS File:
SDS
Modify Date:
2024/6/29 22:56:24

2,2'-Dithiosalicylic acid Properties

Melting point 287-290 °C(lit.)
Boiling point 416.97°C (rough estimate)
Density 1.4555 (rough estimate)
vapor pressure 0Pa at 25℃
refractive index 1.4950 (estimate)
storage temp. Refrigerator
solubility DMSO (Slightly), Methanol (Slightly)
form Powder
pka 3.02±0.36(Predicted)
color Brown
Water Solubility insoluble
BRN 2221810
InChIKey LBEMXJWGHIEXRA-UHFFFAOYSA-N
LogP 1.61 at 25℃ and pH6.2-6.48
CAS DataBase Reference 119-80-2(CAS DataBase Reference)
EPA Substance Registry System Benzoic acid, 2,2'-dithiobis- (119-80-2)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36-24/25
WGK Germany  3
RTECS  DG9660000
Hazard Note  Harmful/irritant
TSCA  Yes
HS Code  29309070
Toxicity LD50 ipr-mus: 367 mg/kg ARZNAD 21,284,71
NFPA 704
1
2 0

2,2'-Dithiosalicylic acid price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) PHR2590 Thimerosal Related Compound A Pharmaceutical Secondary Standard; Certified Reference Material 119-80-2 100MG ₹45529.95 2022-06-14 Buy
Sigma-Aldrich(India) 43761 2,2′-Dithiodibenzoic acid ≥95.0% (NT) 119-80-2 100G ₹3279.98 2022-06-14 Buy
TCI Chemicals (India) D1437 2,2'-Dithiodibenzoic Acid 119-80-2 25G ₹4200 2022-05-26 Buy
TCI Chemicals (India) D1437 2,2'-Dithiodibenzoic Acid 119-80-2 100G ₹9800 2022-05-26 Buy
TCI Chemicals (India) D1437 2,2'-Dithiodibenzoic Acid 119-80-2 500G ₹33200 2022-05-26 Buy
Product number Packaging Price Buy
PHR2590 100MG ₹45529.95 Buy
43761 100G ₹3279.98 Buy
D1437 25G ₹4200 Buy
D1437 100G ₹9800 Buy
D1437 500G ₹33200 Buy

2,2'-Dithiosalicylic acid Chemical Properties,Uses,Production

Chemical Properties

brown powder

Uses

2,2'-Dithiosalicylic acid is an organosulfur compound produced from dibenzothiophene metabolites that is in turn biodegraded into transient metabolites such as benzoic acid.It is used in the preparation of a new class of anti-HIV-1 agents.

General Description

2,2′-Dithiodibenzoic acid is an sulfhydryl modifying reagent. 2,2′-Dithiodibenzoic acid on cocrystallization with imidazole or 4-methylimidazole affords bis(imidazolium) 2,2′-dithiodibenzoate and 4-methylimidazolium 2-[(2-carboxyphenyl)disulfanyl]benzoate organic salt, respectively. It also cocrystallizes with isonicotinohydrazide from methanol solution to afford the 1:2 cocrystal, 2,2′-dithiodibenzoic acid-isonicotinohydrazide.

Safety Profile

Poison by intraperitoneal route.When heated to decomposition it emits toxic vapors ofSOx.

Synthesis

A preparation method of 2,2'-dithiosalicylic acid is as follows: using anthranilic acid as raw material and performing a diazotization reaction with sodium nitrite and hydrochloric acid at 0 to 10°C to obtain a diazo liquid. The liquid reacts with liquid sulfur dioxide for 0.5 to 3 hours in the presence of a catalyst and a cocatalyst at -20~~-10°C and then is kept at 80~100°C for 0.5~2 hours, cooled, and filtered to obtain 2,2'-Dithiosalicylic acid.

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2,2'-Dithiodibenzoic acid >=95.0% (NT) 2,2’-dithiobis(benzoicacid) 2,2’-dithiobis-benzoicaci Thimerosal Related Compound A 2,2'-DITHIOSALICYLIC ACID, TECH., 85% 2-Hydroxybenzenecarbothioic acid 2-Carboxyphenyl disulfide, Bis(2-carboxyphenyl) disulfide, Dithiosalicylic acid 2,2'-DITHIOBENZOCI ACID 2,2 -DITHIOSALICYCLIC ACID 2,2 '-dithio-dibenzoate 2-Hydroxybenzenethionothiolic acid o-Hydroxydithiobenzoic acid 2'-Dithiodibenzoic acid 2,2'-Dithiodibenzoic Benzoic acid, 2,2-dithiobis- 2,2'-Dithiosalicylic acid 82% DL-Tryptophan, 5-methoxy- NSC 405662 Bis(o-carboxylphenyl)disulfide 2,2'-Dithiosalicylic acid,98% NSC 213 NSC 5346 NSC 633230 o,o'-Dithiodibenzoic acid 2,2'-DITHIODIBENZOIC ACID FOR SYNTHESIS DTSA)2,2′-Dithiodiben 2,2'-Dithiosalicylic acid(DTSA) 2,2’-dithiodibenzoesaeure 2,2’-dithiodi-benzoicaci bis(o-carboxyphenyl)disulfide AKOS AUF01570 2-(2-CARBOXYPHENYL)DISULFANYLBENZOIC ACID 2,2'-DITHIOSALICYLIC ACID 2,2'-DITHIODIBENZOIC ACID 2,2-DITHIODIBENZOIC ACID 2,2'-DITHIOBENZOIC ACID 2,2-DITHIOBENZOIC ACID 2-CARBOXYPHENYL DISULFIDE BIS(2-CARBOXYPHENYL) DISULFIDE DIPHENYL DISULFIDE-2,2'-DICARBOXYLIC ACID di(2-carboxyphenyl) disulphide 2-Carboxyphenyl disulfide 2,2'-Dithiodibenzoic Acid 2,2'-Dithiosalicy acid 2,2'-Disulphanediyldibenzoic acid 82% 2-[(2-carboxylatophenyl)disulfanyl]benzoate 2,2-Dithiodibenzoic acid(Technical) 2,2'-Dithiodibenzoic Acid > 2,2'-Dithiosalicylic acid (DSTA) Thimerosal Related Compound A (2,2''-Disulfanediyldibenzoic acid) (1659001) DSTA 2,2'-disulfanediyldibenzoic acid DITHIOSALICYLIC ACID Dithioslicylicacid 2,2'-Dithiosalicylic acid 2,2'-Dithiodibenzoic acid 2,2'- dithiobenzoic acid 119-80-2 119-60-7