EC 3.4.15.1
- CAS No.
- 9015-82-1
- Chemical Name:
- EC 3.4.15.1
- Synonyms
- ACE;ANGIOTENSIN CONVERTING ENZYME;ACE (HUMAN);EC 3.4.15.1;ACE (enzyme);Carboxycathepsin;Carboxypeptidase Zace2;PEPTIDYLDIPEPTIDE HYDROLASE;ACE, Peptidyl-dipeptidaseA;Dipeptidyl carboxypeptidase A
- CBNumber:
- CB3358160
- Molecular Formula:
- C2H5NO
- Molecular Weight:
- 59.0672
- MOL File:
- 9015-82-1.mol
- Modify Date:
- 2024/7/2 8:55:06
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H334 |
| Precautionary statements | P261-P284-P501 |
| WGK Germany | 3 |
| F | 10-21 |
EC 3.4.15.1 price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | A6778 | Angiotensin Converting Enzyme from rabbit lung ≥2.0?units/mg protein (modified Warburg-Christian) | 9015-82-1 | 0.1UNIT | ₹7714.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A6778 | Angiotensin Converting Enzyme from rabbit lung ≥2.0?units/mg protein (modified Warburg-Christian) | 9015-82-1 | 0.25UNIT | ₹16228.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A6778 | Angiotensin Converting Enzyme from rabbit lung ≥2.0?units/mg protein (modified Warburg-Christian) | 9015-82-1 | 1UNIT | ₹50915.7 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A6778 | Angiotensin Converting Enzyme from rabbit lung ≥2.0?units/mg protein (modified Warburg-Christian) | 9015-82-1 | 2UNITS | ₹92107.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | A6778 | Angiotensin Converting Enzyme from rabbit lung ≥2.0?units/mg protein (modified Warburg-Christian) | 9015-82-1 | 5UNITS | ₹199467 | 2022-06-14 | Buy |
EC 3.4.15.1 Chemical Properties,Uses,Production
Uses
Angiotensin converting enzyme from rabbit lung has been used:
- for measuring inhibitory effect of egg white protein hydrolysates on ACE activity by high performance liquid chromatography (HPLC)
- to measure the ACE inhibition by litchi pericarp and cooked chicken breast using hippuryl-L-histidyl-L-leucine (HHL) as substrate by reverse phase-HPLC (RP-HPLC)3 and HPLC respectively
- in releasing GPI anchored protein in vitro in few cell lines like HeLa, HEK293 and in vivo in mice sperm.
General Description
The angiotensin-converting enzyme (ACE) is a dipeptidyl-carboxypeptidase which exists in somatic and testicular isoforms with zinc binding motif HEXXH in their active site. ACE regulates blood pressure through renin-angiotensin system. ACE elevates blood pressure by converting angiotensin I to a key vasoconstrictor angiotensin II and inhibiting a potent vasodilator bradykinin. Inhibition of ACE is a targeted therapeutic strategy for high blood pressure. Several ACE synthetic inhibitory peptides available for clinical use include captopril, enalapril and lisinopril. Currently, developing inhibitory peptides from natural food sources, or phenolic compounds from plant sources to inhibit ACE is underway. ACE plays a critical role in fertilization by releasing the proteins anchored to glycosylphosphatidylinositol (GPI) in sperm membrane.
Purification Methods
Purify ACE by fractionation on DEAE-cellulose, Ca phosphate gel chromatography, elution from Sephadex G-200 and lectin affinity chromatography. The MW varied with glycosidation and is higher by gel filtration. It contains one atom of Zn/mol and has Km values for hydrolysis of hippurylhistidinylleucine and angiotensin I of 2.3 and 0.07 mM, and turnover of 15,430 and 792 mol/min/mol at 37o, respectively. The activity is inhibited by EDTA and increased amounts of Ca ions but required Ca ions. [Das & Soffer J Biol Chem 250 6762 1975, Reviewed by Ehlers & Riordan Biochemistry 28 5311 1989.]
EC 3.4.15.1 Preparation Products And Raw materials
Raw materials
Preparation Products
EC 3.4.15.1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
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| Watson Biotechnology Co.,Ltd | +86-18186686046 +86-18186686046 | China | 5822 | 58 | Inquiry |
| Lingyuan Bebiansen Biological Technology Co., Ltd | 18642120371 | China | 7994 | 58 | Inquiry |
| Beijing Boorsen Biotechnology Co., Ltd | 400-901-9800 18611424007 | China | 9518 | 58 | Inquiry |
| Shenzhen Regent Biochemical Technology Co., Ltd. | 0755-0755-85201366 18938635012 | China | 9305 | 58 | Inquiry |
| Shanghai Huzhen Industrial Co., LTD | 021-60345367 13916550749 | China | 9965 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | 029-81124267 15229202216 | China | 10011 | 58 | Inquiry |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | China | 4550 | 62 | Inquiry |