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Hexamethylene bisacetamide

CAS No.: 3073-59-4

Chemical Name:: Hexamethylene bisacetamide

Synonyms: NSC-95580;1,6-DIACETAMIDOHEXANE;1,6-Hexanebisacetamide;Hexamethylenediacetamide;hexamethylenebisacetamide;HEXAMETHYLENE BISCETAMIDE;Hexamethylene bisacetamide;N,N'-Diacetyl-1,6-hexadiamine;N-(6-acetamidohexyl)acetamide;N,N'-HEXAMETHYLENEBISACETAMIDE

CBNumber:: CB3374289

Molecular Formula:: C10H20N2O2

Molecular Weight:: 200.28

MOL File:: 3073-59-4.mol

MSDS File:: SDS

Modify Date:: 2024/7/23 10:38:52

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Hexamethylene bisacetamide Properties

Melting point	128-129 °C(lit.)
Boiling point	338.01°C (rough estimate)
Density	0.974
refractive index	1.4710 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	water: soluble5%, clear, colorless
pka	16.20±0.46(Predicted)
form	A solid
BRN	1775764
InChI	InChI=1S/C10H20N2O2/c1-9(13)11-7-5-3-4-6-8-12-10(2)14/h3-8H2,1-2H3,(H,11,13)(H,12,14)
InChIKey	BNQSTAOJRULKNX-UHFFFAOYSA-N
SMILES	C(NC(=O)C)CCCCCNC(=O)C
CAS DataBase Reference	3073-59-4(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Risk Statements

Safety Statements

22-24/25

WGK Germany

RTECS

AC2976200

HS Code

29241990

Toxicity

human,TDLo,intravenous,4270mg/kg/10D (4270mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGBLOOD: THROMBOCYTOPENIA,Cancer Research. Vol. 47, Pg. 5788, 1987.

NFPA 704

	0
1		0

Hexamethylene bisacetamide price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	224235	N,N′-Hexamethylene bis(acetamide) 98%	3073-59-4	10G	₹2154.18	2022-06-14	Buy
Sigma-Aldrich(India)	224235	N,N′-Hexamethylene bis(acetamide) 98%	3073-59-4	50G	₹2933.58	2022-06-14	Buy

Product number	Packaging	Price	Buy
224235	10G	₹2154.18	Buy
224235	50G	₹2933.58	Buy

Hexamethylene bisacetamide Chemical Properties,Uses,Production

Chemical Properties

white crystalline powder or flakes

Uses

N,N′-Hexamethylene bis(acetamide) was used as an inducing agent in obtaining mononuclear cells from the peripheral blood (PB) sample by Ficoll-Hypaque gradient separation.

Biological Activity

Hexamethylene bisacetamide is a tumor cell-differentiating agent. It induces complete differentiation of 754A murine erythroleukemia cells when used at a concentration of 5 mM. Hexamethylene bisacetamide also induces latent HIV-1 viral production in chronically HIV-1-infected U1 cells in a concentration-dependent manner. Implantation of HT-29 colon cancer cells cultured with hexamethylene bisacetamide for seven days, but not 28, reduces tumorigenesis of those cells in mice. Hexamethylene Bisacetamide (HMBA) is a hybrid polar compound originally developed as a differentiation-inducing agent. HMBA can inhibit the activation of several NF kappaB target genes in both lung and breast cancer cell lines. Furthermore, consistent with its ability to inhibit NF kappaB function, HMBA can also sensitize cells to apoptosis. HMBA mediates inhibition of the Akt and ERK/MAPK cascade, both critical for cell survival and proliferation and are well-known regulators of NF kappaB activation[1].

References

[1] Anwesha Dey. “Hexamethylene bisacetamide (HMBA) simultaneously targets AKT and MAPK pathway and represses NF kappaB activity: implications for cancer therapy.” Cell Cycle 7 23 (2008): 3759–67.

Hexamethylene bisacetamide Preparation Products And Raw materials

Raw materials

Preparation Products

Hexamethylene bisacetamide Suppliers

Global( 74)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CHEMSWORTH	+91-261-2397244	New Delhi, India	6707	30	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
DSHare Pharmaceutical Science Technology Co.Ltd.	+8613962878782	China	42	58	Inquiry
Shaanxi Dideu Medichem Co. Ltd	+86-029-81138252 +86-18789408387	China	3100	58	Inquiry
Kindchem(Nanjing)Co.,Ltd	+86-025-025-85281586 +8618651653755	China	1227	58	Inquiry
Golden Pharma Co., Limited	+undefined18958062155	China	5905	58	Inquiry
Henan Aochuang Chemical Co.,Ltd.	+86-0371-63689365 +8618638391208	China	9425	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
Henan Allgreen Chemical Co.,LTD	+86-37155567971 +86-13633837469	China	5986	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry

Supplier	Advantage
CHEMSWORTH	30
CLEARSYNTH LABS LTD.	58
DSHare Pharmaceutical Science Technology Co.Ltd.	58
Shaanxi Dideu Medichem Co. Ltd	58
Kindchem(Nanjing)Co.,Ltd	58
Golden Pharma Co., Limited	58
Henan Aochuang Chemical Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Henan Allgreen Chemical Co.,LTD	58
LEAPCHEM CO., LTD.	58

Hexamethylene bisacetamide Spectrum

N,N'-DIACETYL-1,6-DIAMINOHEXANE(3073-59-4)MS N,N'-DIACETYL-1,6-DIAMINOHEXANE(3073-59-4)¹HNMR N,N'-DIACETYL-1,6-DIAMINOHEXANE(3073-59-4)IR1 N,N'-DIACETYL-1,6-DIAMINOHEXANE(3073-59-4)IR2 N,N'-DIACETYL-1,6-DIAMINOHEXANE(3073-59-4)Raman

3073-59-4(Hexamethylene bisacetamide)Related Search:

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Acetamide, N,N'-1,6-hexanediylbis- N,N'-HEXAMETHYLENEBISACETAMIDE N,N'-DIACETYL-1,6-DIAMINOHEXANE N,N'-DIACETYL-1,6-HEXANEDIAMINE 1,6-Hexanebisacetamide N,N'-(Hexane-1,6-diyl)diacetaMide N,N'-Diacetyl-1,6-diaminohexane, 98+% N,N'-Diacetyl-1,6-hexadiamine N,Nμ-Diacetyl-1,6-hexanediamine, HMBA N,N'-Hexamethylenebisacetamide,98% Acetamide, N,N'-hexamethylenebis- Hexamethylene bisacetamide hexamethylenebisacetamide Hexamethylenediacetamide n,n’-1,6-hexanediylbis-acetamid n,n’-1,6-hexanediylbisacetamide n,n’-diacetylhexamethylenediamine n,n’-hexamethylenebis-acetamid N,N'-Diacetylhexamethylenediamine N-[6-(Acetylamino)hexyl]acetamide NSC-95580 1,6-DIACETAMIDOHEXANE HEXAMETHYLENE BISCETAMIDE N-(6-acetamidohexyl)acetamide Inhibitor,Hexamethylene bisacetamide,HMBA,inhibit N,N'-Diacetyl-1,6-diarninohexane N,N'-DIACETYL-1,6-DIAMINOHEXANE 3073-59-4 C4H14O2N2 CH3CONHCH26NHCOCH3 Nitrogen Compounds Organic Building Blocks Protected Amines Building Blocks