Endosidin 2
- CAS No.
- 1839524-44-5
- Chemical Name:
- Endosidin 2
- Synonyms
- Endosidin 2;Endosidin-2 (ES-2);3-fluoro-benzoicacid,(2E)-2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylene]hydrazide;Benzoic acid, 3-fluoro-, (2E)-2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylene]hydrazide
- CBNumber:
- CB34666449
- Molecular Formula:
- C15H12FIN2O3
- Molecular Weight:
- 414.17
- MOL File:
- 1839524-44-5.mol
- Modify Date:
- 2023/7/14 17:49:01
| Density | 1.67±0.1 g/cm3(Predicted) |
|---|---|
| storage temp. | 2-8°C |
| solubility | Soluble in DMSO (greater than 40 mg/ml), in DMF (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml) |
| form | powder |
| pka | 7.75±0.36(Predicted) |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20°C for up to 1 month. |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| NFPA 704 |
|
Endosidin 2 price More Price(2)
Endosidin 2 Chemical Properties,Uses,Production
Uses
Endosidin 2 binds to the EXO70 (exocyst component of 70 kDa) subunit of the exocyst complex, resulting in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking. A valuable tool for exocytosis studies.
Biochem/physiol Actions
Endosidin2 is a cell-permeable benzylidene-benzohydrazide based compound that binds to the exocyst component of 70 kDa (EXO70) subunit of exocyst complex (Kd?= 253 μM for interaction with EXO70A1) and reduces exocytosis and endosomal recycling in plant and mammalian cells. Displays good aqueous stability. Endosidin2 has shown to disrupt the trafficking of proteins between the plasma membrane and endosome, which leads to enhanced trafficking to the vacuole for degradation. It is reported to inhibit the recycling of endocytosed transferrin to plasma membrane in HeLa cells, and can target multiple isoforms of EXO70 in mammals, resulting in misregulation of exocytosis.
Endosidin 2 Preparation Products And Raw materials
Raw materials
Preparation Products
Endosidin 2 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| Jingmo (Xiamen) Biotechnology Co., Ltd | 13621943973 13515979683 | China | 1085 | 58 | Inquiry |
| United States Biological | 1-800-520-3011 | United States | 6106 | 58 | Inquiry |
| Shanghai Hao Zhun Biological Technology Co., Ltd. | 15800340161 | CHINA | 6846 | 58 | Inquiry |
| Sigma-Aldrich | 021-61415566 800-8193336 | China | 51471 | 80 | Inquiry |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | China | 11289 | 58 | Inquiry |
| United States Biological | 800.520.3011 or 781.639.5092 | United States | 6256 | 80 | Inquiry |
| EBRATOR BIOCHEMICALS,INC. | (714)-884-4183 | United States | 577 | 58 | Inquiry |
| Focus Biomolecules | 855-362-8721 | United States | 1284 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 4008200310 | China | 24016 | 58 | Inquiry |