N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-aMine
- CAS No.
- 662163-81-7
- Chemical Name:
- N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-aMine
- Synonyms
- CS-2426;ImportazoL;Importazole;Apoptosis,Importazole,Inhibitor,inhibit;N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-aMine;4-Quinazolinamine, N-(1-phenylethyl)-2-(1-pyrrolidinyl)-
- CBNumber:
- CB62640068
- Molecular Formula:
- C20H22N4
- Molecular Weight:
- 318.42
- MOL File:
- 662163-81-7.mol
- Modify Date:
- 2023/9/4 16:42:00
| Boiling point | 516.8±42.0 °C(Predicted) |
|---|---|
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: >5mg/mL |
| pka | 7.27±0.59(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months. |
N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-aMine price More Price(2)
N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-aMine Chemical Properties,Uses,Production
Description
Importazole is a cell-permeable inhibitor of importin-β, which transports cargo molecules bearing a nuclear localization signal into the nucleus. Importazole prevents nuclear import of GFP-tagged nuclear factor of activated T cells (NFAT-GFP) in HEK293 cells (IC50 = 15 μM), which is reversible upon importazole washout. Importazole does not interfere with transportin-mediated nuclear import or chromosomal maintenance 1 (CRM1)-mediated nuclear export. Importazole inhibits nuclear import of topoisomerase IIβ binding protein 1 (TopBP1) in Xenopus egg extracts and of NF-κB in multiple myeloma cells. It also induces defects in spindle and microtubule formation in vitro.
Uses
Importazole is an importin-β inhibitor.
Biochem/physiol Actions
Importazole is an inhibitor of importin-β transport receptors. During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. Importazole somehow disrupts the importin/RAN interaction. Importazole is selective among other transporters. Compounds are imported into, but not out of, cells.
N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-aMine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| A.J Chemicals | 91-9810153283 | New Delhi, India | 6124 | 58 | Inquiry |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | China | 32836 | 60 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29825 | 58 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
| Tianjin Xinshengjiahe Science & Technology Development Co,.Ltd | +86-86-22-87899925 +86-8618522618860 | China | 694 | 58 | Inquiry |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | China | 10522 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| LEAP CHEM CO., LTD. | +86-852-30606658 | China | 24738 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | China | 11681 | 58 | Inquiry |