N-(1-페닐에틸)-2-(피롤리딘-1-일)퀴나졸린-4-아민
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N-(1-페닐에틸)-2-(피롤리딘-1-일)퀴나졸린-4-아민 속성
- 끓는 점
- 516.8±42.0 °C(Predicted)
- 밀도
- 1?+-.0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- 에 용해됨 DMSO: >5mg/mL
- 산도 계수 (pKa)
- 7.27±0.59(Predicted)
- 물리적 상태
- 가루
- 색상
- 흰색에서 베이지색
- 안정성
- 제공된 대로 구매일로부터 1년 동안 안정적입니다. DMSO의 솔루션은 -20°에서 최대 3개월 동안 보관할 수 있습니다.
안전
| WGK 독일 | 3 |
|---|
N-(1-페닐에틸)-2-(피롤리딘-1-일)퀴나졸린-4-아민 C화학적 특성, 용도, 생산
개요
Importazole is a cell-permeable inhibitor of importin-β, which transports cargo molecules bearing a nuclear localization signal into the nucleus. Importazole prevents nuclear import of GFP-tagged nuclear factor of activated T cells (NFAT-GFP) in HEK293 cells (IC50 = 15 μM), which is reversible upon importazole washout. Importazole does not interfere with transportin-mediated nuclear import or chromosomal maintenance 1 (CRM1)-mediated nuclear export. Importazole inhibits nuclear import of topoisomerase IIβ binding protein 1 (TopBP1) in Xenopus egg extracts and of NF-κB in multiple myeloma cells. It also induces defects in spindle and microtubule formation in vitro.용도
Importazole is an importin-β inhibitor.Biochem/physiol Actions
Importazole is an inhibitor of importin-β transport receptors. During interphase, the transport receptor importin-β carries cargoes into the nucleus, where RanGTP releases them. Importazole somehow disrupts the importin/RAN interaction. Importazole is selective among other transporters. Compounds are imported into, but not out of, cells.N-(1-페닐에틸)-2-(피롤리딘-1-일)퀴나졸린-4-아민 준비 용품 및 원자재
원자재
준비 용품
N-(1-페닐에틸)-2-(피롤리딘-1-일)퀴나졸린-4-아민 공급 업체
글로벌( 72)공급 업체
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