N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-aMine
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- ₹13253.4 - ₹52480.8
- Product name: N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-aMine
- CAS: 662163-81-7
- MF: C20H22N4
- MW: 318.42
- EINECS:
- MDL Number:MFCD04077630
- Synonyms:N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-aMine;Importazole;CS-2426;ImportazoL;4-Quinazolinamine, N-(1-phenylethyl)-2-(1-pyrrolidinyl)-;Apoptosis,Importazole,Inhibitor,inhibit
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0341
- Product descriptionImportazole ≥98% (HPLC)
- Packaging25MG
- Price₹52480.8
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0341
- Product descriptionImportazole ≥98% (HPLC)
- Packaging5MG
- Price₹13253.4
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0341 | Importazole ≥98% (HPLC) | 25MG | ₹52480.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0341 | Importazole ≥98% (HPLC) | 5MG | ₹13253.4 | 2022-06-14 | Buy |
Properties
Boiling point :516.8±42.0 °C(Predicted)
Density :1?+-.0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
pka :7.27±0.59(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Density :1?+-.0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >5mg/mL
pka :7.27±0.59(Predicted)
form :powder
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
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Description
Importazole is a cell-permeable inhibitor of importin-β, which transports cargo molecules bearing a nuclear localization signal into the nucleus. Importazole prevents nuclear import of GFP-tagged nuclear factor of activated T cells (NFAT-GFP) in HEK293 cells (IC50 = 15 μM), which is reversible upon importazole washout. Importazole does not interfere with transportin-mediated nuclear import or chromosomal maintenance 1 (CRM1)-mediated nuclear export. Importazole inhibits nuclear import of topoisomerase IIβ binding protein 1 (TopBP1) in Xenopus egg extracts and of NF-κB in multiple myeloma cells. It also induces defects in spindle and microtubule formation in vitro.Related product price
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