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ChemicalBook > Product Catalogue >API >Antibiotics >Other antibiotic Drugs >Brefeldin A

Brefeldin A

Brefeldin A Structure
  • ₹9500 - ₹84088.6
  • Product name: Brefeldin A
  • CAS: 20350-15-6
  • MF: C16H24O4
  • MW: 280.36
  • EINECS:606-528-3
  • MDL Number:MFCD12913297
  • Synonyms:NSC 107456;(1R,2E,6S,10E,11aS,13S,14aR)-1,13-dihydroxy-6-Methyl-6,7,8,9,12,13,14,14a-octahydro-1H-cyclopenta[f][1]oxacyclotridecin-4(11aH)-one;Ascotoxin, Cyanein, DecuMbin;Brefeldin A, FroM EupenicilliuM brefeldianuM;NECTROLIDE;SYNERGISIDIN;4h-cyclopent(f)oxacyclotridecin-4-one,1,6,7,8,9,11a-beta,12,13,14,14a-alpha-de ;cahydro-1-beta-13-alpha-dihydroxy-6-beta-methyl-
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Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 2MG
  • 200μL
  • 1MG
  • 5MG
  • 10MG
  • 25MG
  • 50MG
  • ManufacturerTCI Chemicals (India)
  • Product numberB3820
  • Product descriptionBrefeldin A
  • Packaging10MG
  • Price₹9500
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB3820
  • Product descriptionBrefeldin A
  • Packaging50MG
  • Price₹35200
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number203729
  • Product description(+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis
  • Packaging1MG
  • Price₹10680
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number5.00583
  • Product descriptionInSolution (+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem A 25 mM solution of (+)-Brefeldin A in DMSO.
  • Packaging2MG
  • Price₹12940
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberB5936
  • Product descriptionBrefeldin A from Penicillium brefeldianum, Ready Made Solution, 10?mg/mL in DMSO
  • Packaging200μL
  • Price₹15255.1
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberB7651
  • Product descriptionBrefeldin A from Penicillium brefeldianum, ≥99% (HPLC and TLC)
  • Packaging5MG
  • Price₹23230.45
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberB7651
  • Product descriptionBrefeldin A from Penicillium brefeldianum, ≥99% (HPLC and TLC)
  • Packaging25MG
  • Price₹84088.6
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B3820 Brefeldin A 10MG ₹9500 2022-05-26 Buy
TCI Chemicals (India) B3820 Brefeldin A 50MG ₹35200 2022-05-26 Buy
Sigma-Aldrich(India) 203729 (+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem Specifically and reversibly blocks translocation of proteins from the endoplasmic reticulum (ER) to the Golgi apparatus without affecting endocytosis 1MG ₹10680 2022-06-14 Buy
Sigma-Aldrich(India) 5.00583 InSolution (+)-Brefeldin A, Eupenicillium brefeldianum - CAS 20350-15-6 - Calbiochem A 25 mM solution of (+)-Brefeldin A in DMSO. 2MG ₹12940 2022-06-14 Buy
Sigma-Aldrich(India) B5936 Brefeldin A from Penicillium brefeldianum, Ready Made Solution, 10?mg/mL in DMSO 200μL ₹15255.1 2022-06-14 Buy
Sigma-Aldrich(India) B7651 Brefeldin A from Penicillium brefeldianum, ≥99% (HPLC and TLC) 5MG ₹23230.45 2022-06-14 Buy
Sigma-Aldrich(India) B7651 Brefeldin A from Penicillium brefeldianum, ≥99% (HPLC and TLC) 25MG ₹84088.6 2022-06-14 Buy

Properties

Melting point :200-205 °C
Boiling point :492.7±45.0 °C(Predicted)
alpha :93 º (C=2 IN MEOH)
Density :1.108±0.06 g/cm3(Predicted)
vapor pressure :0.56 hPa ( 20 °C)
Flash point :87 °C
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :methanol: 10 mg/mL, clear, colorless to faintly yellow
pka :12.92±0.60(Predicted)
form :Crystalline Powder
color :White to almost white
Water Solubility :Soluble in dimethylsulfoxide, dichloromethane and ethanol. Slightly soluble in water.
Merck :13,1355
BRN :25191
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
InChIKey :QSECOIOBNZLGOD-OBCVZTHZSA-N
CAS DataBase Reference :20350-15-6

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Description

Brefeldin A (BFA) is a natural fungal metabolite which has been used extensively to study intracellular transport by vesicles or endosomes. Early studies demonstrated that BFA reversibly interferes with protein trafficking and secretion mediated by the Golgi apparatus and endoplasmic reticulum. BFA directly and reversibly inhibits Sec7 domain-containing guanine-exchange factors which are necessary for ADP-ribosylation factor activation associated with vesicular transport (IC50 = ~10 μM). BFA is used to study endosomal trafficking and function in cells of plants as well as those of fungi, invertebrates, and vertebrates.

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