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HUMULONE

HUMULONE Structure
CAS No.
26472-41-3
Chemical Name:
HUMULONE
Synonyms
HUMULONE;α-bitter acid;[R,(-)]-Humulone;HUMULONE USP/EP/BP;Phloroglucinol Impurity T;(R)-Humulone DISCONTINUED;α-Bitter acid, α-Lupulic acid;Humulone, mixture of homologues;(6R)-3,5,6-trihydroxy-2-isovaleryl-4,6-bis(3-methylbut-2-enyl)cyclohexa-2,4-dienone;(6R)-4,6-Diprenyl-3,5,6-trihydroxy-2-(1-oxo-3-methylbutyl)-2,4-cyclohexadiene-1-one
CBNumber:
CB3497674
Molecular Formula:
C21H30O5
Molecular Weight:
362.46
MOL File:
26472-41-3.mol
Modify Date:
2024/7/2 8:55:06

HUMULONE Properties

Melting point 65-66.5℃
alpha D20 -212° (1.0 g in 15.5 g 96% alc)
Boiling point 414.06°C (rough estimate)
Density 1.157±0.06 g/cm3 (20 ºC 760 Torr)
refractive index 1.6120 (estimate)
storage temp. −20°C
solubility DMSO : 100 mg/mL (275.89 mM; Need ultrasonic)
form Powder
pka 4.50±1.00(Predicted)
color Light yellow to yellow

SAFETY

Risk and Safety Statements

WGK Germany  3
10-23

HUMULONE Chemical Properties,Uses,Production

Uses

(R)-Humulone (CAS# 26471-41-3) can be used as a chemosensory receptor ligand.

Purification Methods

Crystallise humulon from Et2O. It dissolves slightly in hot H2O but precipitates on cooling. It has max () 237 (13,760) and 282 (8,330) in EtOH. [Wollmer Chem Ber 49 780 1916, Carson J Am Chem Soc 73 4652 1951, Beilstein 8 II 537, 8 III 4034, 8 IV 3410.]

HUMULONE Preparation Products And Raw materials

Global( 45)Suppliers
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CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Chengdu GLP biotechnology Co Ltd 028-87075086 13350802083 CHINA 1824 58 Inquiry
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Dideu Industries Group Limited +86-29-89586680 +86-15129568250 China 26216 58 Inquiry
Hangzhou MolCore BioPharmatech Co.,Ltd. +86-057181025280; +8617767106207 China 49739 58 Inquiry
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Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Nantong Hanfang Biotechnology Co. , Ltd. 18616537568 China 30968 58 Inquiry
Chengdu Push Bio-Technology Co., Ltd. 028-85370565-229 18080489829 China 9408 60 Inquiry
Foshan Treasure Biotechnology Co., Ltd 0757-85921206 18520245316 China 12664 58 Inquiry
(6R)-3,5,6-trihydroxy-2-isovaleryl-4,6-bis(3-methylbut-2-enyl)cyclohexa-2,4-dienone α-bitter acid Humulone, mixture of homologues α-Bitter acid, α-Lupulic acid (6R)-2-(3-Methylbutyryl)-3,5,6-trihydroxy-4,6-bis(3-methyl-2-butenyl)-2,4-cyclohexadiene-1-one (6R)-4,6-Diprenyl-3,5,6-trihydroxy-2-(1-oxo-3-methylbutyl)-2,4-cyclohexadiene-1-one [R,(-)]-3,5,6-Trihydroxy-4,6-bis(3-methyl-2-butenyl)-2-(3-methyl-1-oxobutyl)-2,4-cyclohexadien-1-one [R,(-)]-Humulone HUMULONE (6S)-3,5,6-trihydroxy-2-(3-methylbutanoyl)-4,6-bis(3-methylbut-2-enyl)cyclohexa-2,4-dien-1-one 2,4-Cyclohexadien-1-one,3,5,6-trihydroxy-4,6-bis(3-methyl-2-buten-1-yl)-2-(3-methyl-1-oxobutyl)-, (6R)- HUMULONE USP/EP/BP (R)-Humulone DISCONTINUED Phloroglucinol Impurity T (R)-3,5,6-Trihydroxy-4,6-bis(3-methylbut-2-en-1-yl)-2-(3-methylbutanoyl)cyclohexa-2,4-dienone 26472-41-3 Miscellaneous Natural Products