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GW583340 DIHYDROCHLORIDE

GW583340 DIHYDROCHLORIDE Structure
CAS No.
388082-81-3
Chemical Name:
GW583340 DIHYDROCHLORIDE
Synonyms
4-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]P;4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-;4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride;N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinaminedihydrochloride
CBNumber:
CB3503522
Molecular Formula:
C28H25ClFN5O3S2
Molecular Weight:
598.11
MOL File:
388082-81-3.mol
Modify Date:
2023/5/4 17:34:38
Request For Quotation

GW583340 DIHYDROCHLORIDE Properties

Melting point 259.8-262.4 °C(lit.)
storage temp. 2-8°C
solubility DMSO: 9 mg/mL
form solid

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3

GW583340 DIHYDROCHLORIDE Chemical Properties,Uses,Production

Biological Activity

Potent dual EGFR/ErbB2 tyrosine kinase inhibitor (IC 50 values are 0.01 and 0.014 μ M respectively). Selectively inhibits growth of human tumor cells overexpressing EGFR and ErbB2: IC 50 values are 0.11 μ M for inhibition of HN5, N87 and BT474 tumor cell lines vs. > 30 μ M for inhibition of non-tumor cell line HFF. In vivo, inhibits tumor growth by ~ 80% in a murine xenograft model following oral administration.

GW583340 DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

GW583340 DIHYDROCHLORIDE Suppliers

Global( 8)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
821-50328103-801 18930552037 China 15839 69 Inquiry
Service Chemical Inc. 888-895-6920 Germany 6350 71 Inquiry
Wako Pure Chemical Industries, Ltd. +81 6 6203 3741 Japan 6819 80 Inquiry
American Custom Chemicals Corporation 858 201 6118 United States 6820 51 Inquiry
SIGMA-RBI 800 736 3690 (Orders) Switzerland 6896 91 Inquiry
Tocris Bioscience +44 (0) 117 916 3333 United Kingdom 5726 77 Inquiry
Absin Bioscience Inc. 021-38015121-8802 CHINA 6208 58 Inquiry
Supplier Advantage
69
Service Chemical Inc. 71
Wako Pure Chemical Industries, Ltd. 80
American Custom Chemicals Corporation 51
SIGMA-RBI 91
Tocris Bioscience 77
Absin Bioscience Inc. 58

388082-81-3(GW583340 DIHYDROCHLORIDE)Related Search:

3-Chloro-4-(3-fluorobenzyloxy)aniline 4-BENZYLOXY-3-CHLOROANILINE 96 GW583340 DIHYDROCHLORIDE (2-Thiazolyl)methylamine
4-[3-CHLORO-4-[(3-FLUOROPHENYL)METHOXY]P 4-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenylamino]-6-[2-[[2-(methylsulfonyl)ethyl]aminomethyl]-4-thiazolyl]quinazoline dihydrochloride N-[3-Chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]-4-quinazolinaminedihydrochloride 4-Quinazolinamine, N-[3-chloro-4-[(3-fluorophenyl)methoxy]phenyl]-6-[2-[[[2-(methylsulfonyl)ethyl]amino]methyl]-4-thiazolyl]- 388082-81-3 C28H25ClFN5O3S22HCl C28H25ClFN5O3S2