ChemicalBook > Product Catalog >Organic Chemistry >Carboxylic acids and derivatives >Carboxylic acid esters and derivatives >Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate

Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate

Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate Structure
CAS No.
887267-53-0
Chemical Name:
Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate
Synonyms
Ethyl 3-(2,5-difluorophenyl);ETHYL 2,5-DIFLUOROBENZOYLACETATE;Ethyl 2,5-difluoro-β-oxobenzenepropanoate;ETHYL 3-(2,5-DIFLUOROPHENYL)-3-OXOPROPANOATE;Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate 95+%;Benzenepropanoic acid, 2,5-difluoro-β-oxo-, ethyl ester;3-(2,5-Difluoro-phenyl)-3-oxo-propionic acid ethyl ester;2-fluoro-3-(3-fluorophenyl)-3-oxopropanoic acid ethyl ester
CBNumber:
CB3689431
Molecular Formula:
C11H10F2O3
Molecular Weight:
228.19
MOL File:
887267-53-0.mol
MSDS File:
SDS
Modify Date:
2023/10/20 10:42:06

Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate Properties

Boiling point 275.7±25.0 °C(Predicted)
Density 1.251±0.06 g/cm3(Predicted)
pka 10.28±0.50(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319
Precautionary statements  P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313
HS Code  2916399090

Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate Chemical Properties,Uses,Production

Uses

Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate is commonly utilized in organic synthesis as C-nucleophiles. One specific example is its reaction with the N-terminal electrophile CF3CHN2, resulting in the formation of CF3-heterocycles, namely ethyl 6-fluoro-4-oxo-1-(2,2,2-trifluoroethyl)-1,4-dihydrocinnoline-3-carboxylate[1].
Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate

References

[1] Arkhipov A, et al. Unexpected Reactivity of Trifluoromethyl Diazomethane (CF3CHN2): Electrophilicity of the Terminal N?Atom. Organic Letters, 2016; 18: 3406–3409.

Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 58)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Capot Chemical Co.,Ltd. 571-85586718 +8613336195806 China 29798 60 Inquiry
Shanghai Gubang New Materail Technology Co. LTD 21-51317962 +8618721305404 CHINA 272 58 Inquiry
Dayang Chem (Hangzhou) Co.,Ltd. 571-88938639 +8617705817739 China 52861 58 Inquiry
PT CHEM GROUP LIMITED China 35426 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 57511 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Cool Pharm, Ltd 021-60455363 18019463053 China 12357 58 Inquiry
Combi-Blocks Inc. 858 635 8950 United States 6632 69 Inquiry
Shanghai Sunway Pharmaceutical Technology Co.,Ltd. 021-51816796-820 13611835272 China 44462 58 Inquiry
ETHYL 3-(2,5-DIFLUOROPHENYL)-3-OXOPROPANOATE ETHYL 2,5-DIFLUOROBENZOYLACETATE 3-(2,5-Difluoro-phenyl)-3-oxo-propionic acid ethyl ester Ethyl 3-(2,5-difluorophenyl) 2-fluoro-3-(3-fluorophenyl)-3-oxopropanoic acid ethyl ester Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate 95+% Benzenepropanoic acid, 2,5-difluoro-β-oxo-, ethyl ester Ethyl 2,5-difluoro-β-oxobenzenepropanoate 887267-53-0