NOGALAMYCIN
- CAS No.
- 1404-15-5
- Chemical Name:
- NOGALAMYCIN
- Synonyms
- U-15167;U 15167;nsc-70845;noramycin;AIDS031122;NOGALAMYCIN;nogalomycin;Nogalamyicn;Nogalamycine;Nogalamycinum
- CBNumber:
- CB3752063
- Molecular Formula:
- C39H49NO16
- Molecular Weight:
- 787.8
- MOL File:
- 1404-15-5.mol
- Modify Date:
- 2023/6/8 9:02:59
| Melting point | 195-196° (dec) |
|---|---|
| alpha | D25 +425° (c = 0.11 in CHCl3) |
| Boiling point | 658.61°C (rough estimate) |
| Density | 1.2095 (rough estimate) |
| refractive index | 1.7650 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMF: Soluble; DMSO: Soluble; Ethanol: soluble; Methanol: Soluble |
| form | A solid |
| pka | 7.45 (60% ethanol) |
| color | Orange-red solid from MeOH |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H312-H332-H350-H360 | |||||||||
| Precautionary statements | P201-P280-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 45-46-61-20/21/22 | |||||||||
| Safety Statements | 53-22-36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RA4550000 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 11.75 i.v., 4.79 i.p. (Hadidian) | |||||||||
| NFPA 704 |
|
NOGALAMYCIN Chemical Properties,Uses,Production
Uses
Nogalamycin is an unusual anthracycline produced by Streptomyces nogalater var. nogalater, reported by researchers at Upjohn in 1965. Nogalamycin contains two saccharides. The neutral monosaccharide attaches to the D ring, similar to the aminoglycoside moieties of the doxorubicin class, while the second, basic saccharide attaches to the phenolic group on the A ring in the ortho position to form a unique family of hexacyclic anthracyclines. Nogalamycin is potent antibacterial and antitumor agent that interacts with DNA by intercalation.
Biochem/physiol Actions
Anthracyclic antitumor antibiotic.
Safety Profile
Poison by intravenous andintraperitoneal routes. Human mutation data reported. Anantibiotic. When heated to decomposition it emits toxicfumes of NOx.
NOGALAMYCIN Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 49)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Fuxin Pharmaceutical | +86-021-021-50872116 +8613122107989 | China | 10297 | 58 | Inquiry |
| SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | China | 5738 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| BOC Sciences | 16314854226; +16314854226 | United States | 19743 | 58 | Inquiry |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 | China | 2969 | 58 | Inquiry |
| RD International Technology Co., Limited | 18024082417 | China | 9155 | 58 | Inquiry |
| TargetMol Chemicals Inc. | 15002134094 | China | 28118 | 58 | Inquiry |
| Shanghai Yanchun Biopharmaceutical Technology Co., Ltd | 4001-009266 17349750668 | China | 2811 | 58 | Inquiry |
| Shanghai Jiahua Herong Biotechnology Co., Ltd | 13296077563 13296077563 | China | 9937 | 58 | Inquiry |
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nsc-70845
NOGALAMYCIN, STREPTOMYCES NOGALATER
NOGALAMYCIN
AIDS031122
NOGALAMYCIN FROM STREPTOMYCES NOGALATER
Nogalamycin >=95%, from Streptomyces nogalater
antibiotic205t3
antibioticnsc70845
nogalomycin
U 15167
U-15167
Nogalamycine
Nogalamycinum
Nogalamyicn
2,6-Epoxy-2H-naphthaceno[1,2-b]oxocin-14-carboxylic acid, 11-[(6-deoxy-3-C-methyl-2,3,4-tri-O-methyl-α-L-mannopyranosyl)oxy]-4-(dimethylamino)-3,4,5,6,9,11,12,13,14,16-decahydro-3,5,8,10,13-pentahydroxy-6,13-dimethyl-9,16-dioxo-, methyl ester, (2R,3S,4R,5R,6R,11S,13S,14R)-
noramycin
1404-15-5
C39H49NO16
Antibiotics
Antibiotics A to Z
Antibiotics N-S
BioChemical
Antibiotics
Antibiotics A to
Antibiotics by Application
Antibiotics N-SAntibiotics
Antineoplastic and Immunosuppressive AntibioticsAntibiotics
Inhibits an EnzymeAntibiotics
Interferes with DNA Synthesis
Mechanism of Action