Glutaraldehyde
- CAS No.
- 111-30-8
- Chemical Name:
- Glutaraldehyde
- Synonyms
- Gluteraldehyde;glutaral;GLUTARIC DIALDEHYDE;1,5-PENTANEDIAL;Pentanedial;GDA;GLUTARDIALDEHYDE;Aqucar;PENTANDIAL;GLUTARADEHYDE
- CBNumber:
- CB3762723
- Molecular Formula:
- C5H8O2
- Molecular Weight:
- 100.12
- MOL File:
- 111-30-8.mol
- Modify Date:
- 2024/4/9 22:15:29
| Melting point | -15 °C |
|---|---|
| Boiling point | 100 °C |
| Density | 1.058 g/mL at 20 °C |
| vapor density | 1.05 (vs air) |
| vapor pressure | 15 mmHg ( 20 °C) |
| refractive index |
n |
| Flash point | 100°C |
| storage temp. | Store below +30°C. |
| solubility | Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly) |
| form | Solution |
| color | Clear to slight haze |
| Specific Gravity | 1.06 |
| PH | >3.0 (H2O, 20°C) |
| Odor | pungent aldehyde odor |
| Water Solubility | miscible |
| Merck | 14,4472 |
| BRN | 605390 |
| Exposure limits | Ceiling (ACGIH) 0.8 mg/m3 (0.2 ppm). |
| Stability | Light Sensitive |
| InChIKey | SXRSQZLOMIGNAQ-UHFFFAOYSA-N |
| LogP | -0.180 (est) |
| CAS DataBase Reference | 111-30-8(CAS DataBase Reference) |
| NIST Chemistry Reference | Glutaral(111-30-8) |
| EPA Substance Registry System | Glutaraldehyde (111-30-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |     GHS05,GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301+H331-H312-H314-H317-H334-H335-H411 | |||||||||
| Precautionary statements | P261-P273-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338 | |||||||||
| Hazard Codes | T,N,Xn | |||||||||
| Risk Statements | 36/37/38-42/43-34-23-22-50-23/25-41-37/38-20/22 | |||||||||
| Safety Statements | 23-26-36/37-45-36/37/39-61 | |||||||||
| RIDADR | UN 2922 8/PG 2 | |||||||||
| OEL | Ceiling: 0.2 ppm (0.8 mg/m3) (Aldehydes) | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MA2450000 | |||||||||
| F | 8-10-23 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 8 | |||||||||
| PackingGroup | II | |||||||||
| HS Code | 29121900 | |||||||||
| Toxicity | LD50 of 25% soln orally in rats: 2.38 ml/kg; by skin penetration in rabbits: 2.56 ml/kg (Smyth) | |||||||||
| NFPA 704 |
|
Glutaraldehyde price More Price(50)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | W512303 | Glutaric dialdehyde solution 50?wt. % in H2O, FCC | 111-30-8 | 1SAMPLE-K | ₹5293.43 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W512303 | Glutaric dialdehyde solution 50?wt. % in H2O, FCC | 111-30-8 | 1KG | ₹7902.25 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G7776 | Glutaraldehyde solution Grade I, 70% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use | 111-30-8 | 10ML | ₹9590.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G7776 | Glutaraldehyde solution Grade I, 70% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use | 111-30-8 | 10X10ML | ₹30310 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | G7651 | Glutaraldehyde solution Grade I, 50% in H2O, specially purified for use as an electron microscopy fixative or other sophisticated use | 111-30-8 | 10ML | ₹9212.08 | 2022-06-14 | Buy |
Glutaraldehyde Chemical Properties,Uses,Production
Description
Glutaraldehyde is a well-known sensitizer among cleaners and health workers. It is also found in X-ray developers products.
Chemical Properties
Glutaraldehyde is a colorless liquid with a pungent odor, which readily changes to a glossy polymer. The Odor Threshold is 0.04 ppm (NY) and 0.2 ppm (NJ). It is miscible in water and organic solvents. Glutaraldehyde may be incompatible with strong oxidizers and strong bases. It should be noted that alkaline solutions containing glutaraldehyde may react with alcohol, ketones, amines, hydrazines, and proteins.
Uses
Glutaraldehyde (Symbol GTA; glutaric dialdehyde, 1,5-pentanedial, glutaral) is commonly used in the medical industry in cold sterilization and in the X-ray development process. It can also be encountered in the leather industry as a tanning ingredient and in mortuary workers. There are no reports which indicate that glutaraldehyde is a naturally occurring compound. Cidex and Acusol, 2% buffered solutions, use this aldehyde as an active ingredient. Sodium bicarbonate is required to activate the solution, which then has a shelf life of 1–2 weeks. Despite health hazards involved with its use, glutaraldehyde is one of the most effective biocides used. It is particularly effective against bacteria and viruses, including the human immunodeficiency virus.
Definition
ChEBI: A dialdehyde comprised of pentane with aldehyde functions at C-1 and C-5.
General Description
Light yellow liquid. Mixes with water.
Air & Water Reactions
Polymerizes in the presence of water.
Reactivity Profile
GLUTARALDEHYDE may discolor on exposure to air. Pentanedial polymerizes on heating. Pentanedial is incompatible with strong oxidizing agents. Pentanedial polymerizes in the presence of water.
Health Hazard
Glutaraldehyde is a strong irritant to the nose,eyes, and skin. In rabbits, 250 μg and 500 mg in 24 hours produced severe irritation in theeyes and skin, respectively. The corrosiveeffect on human skin of 6 mg over 3 dayswas severe. However, the acute toxicity ofglutaraldehyde by the oral and dermal routesis low to mild. Ohsumi and Kuroki (1988)determined that the symptoms of acute toxicityof this compound were less severethan those of formaldehyde. But the restraintof growth was more pronounced in micetreated with glutaraldehyde. An oral LD50value of 1300 mg/kg was reported for mice.Inhalation of this compound can cause upperrespiratory tract irritation, headache, and nervousness.Mice exposed at 33 ppm showedsymptoms of hepatitis.
Fire Hazard
Literature sources indicate that Pentanedial is nonflammable.
Contact allergens
Glutaraldehyde is a well-know sensitizer in cleaners and health workers. It can also be found in X-ray developers or in cosmetics.
Safety Profile
Poison by ingestion, intravenous, and intraperitoneal routes. Moderately toxic by inhalation, skin contact, and subcutaneous routes. Experimental teratogenic and reproductive effects. A severe eye and human skin irritant. Mutation data reported. When heated to decomp osition it emits acrid smoke and irritating fumes. See also ALDEHYDES.
Potential Exposure
Glutaraldehyde is used in leather tanning; in embalming fluids; as a germicide; as a cross-linking agent for protein and polyhydroxy materi als; as a fixative for tissues; and as an intermediate. Buffered solutions are used as antimicrobial agents in hospitals.
Shipping
UN2810 Toxic liquids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Purification Methods
Likely impurities are oxidation products-acids, semialdehydes and polymers. It can be purified by repeated washing with activated charcoal (Norit) followed by vacuum filtration, using 15-20g charcoal/100mL of glutaraldehyde solution. Distil it at 60-65o/15mm, discarding the first 5-10%, then dilute with an equal volume of freshly distilled water at 70-75o, using magnetic stirring under nitrogen. The solution is stored at low temperature (3-4o), in a tightly stoppered container, and protected from light. Standardise by titration with hydroxylamine. [Anderson J Histochem Cytochem 15 652 1967, Beilstein 1 IV 3659.]
Incompatibilities
Water contact forms a polymer solution. A strong reducing agent. Incompatible with strong acids; caustics, ammonia, amines, and strong oxidizers. Note: Alkaline solutions of glutaraldehyde (i.e., activated glutar aldehyde) react with alcohol, ketones, amines, hydrazines, and proteins.
Waste Disposal
Dissolve or mix the material with a combustible solvent and burn in a chemical incinera tor equipped with an afterburner and scrubber. All federal, state, and local environmental regulations must be observed.
Glutaraldehyde Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
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chevron_right| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| PAARICHEM RESOURCES LLP | +91-8104961021 +91-8104961021 | Maharashtra, India | 82 | 58 | Inquiry |
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| DeFINE CHEMICALS | +91-8010769889 +91-9320057099 | Maharashtra, India | 120 | 58 | Inquiry |
| Melzer Chemicals Pvt Ltd | +91-2041004800 +91-2041004800 | Maharashtra, India | 17 | 58 | Inquiry |
| Acuro Organics Limited | +91-8882777000 +91-8882777000 | New Delhi, India | 44 | 58 | Inquiry |
| ALPHA CHEMIKA | +91-22-22061123 +91-22-66382501 | Mumbai, India | 1681 | 43 | Inquiry |
| Scientific OEM | +91-22- 2343 7546 / 2341 3094 | New Delhi, India | 1996 | 38 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Alfa Aesar | 1 800 209 7001 | Maharashtra, India | 6913 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| PAARICHEM RESOURCES LLP | 58 |
| JSK Chemicals | 58 |
| DeFINE CHEMICALS | 58 |
| Melzer Chemicals Pvt Ltd | 58 |
| Acuro Organics Limited | 58 |
| ALPHA CHEMIKA | 43 |
| Scientific OEM | 38 |
| Otto Chemie Pvt. Ltd. | 58 |
| TCI Chemicals (India) Pvt. Ltd. | 58 |
| Alfa Aesar | 58 |
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