LACOSAMIDE
- CAS No.
- 175481-36-4
- Chemical Name:
- LACOSAMIDE
- Synonyms
- ViMpat;Erlosamide;Lacosamide API;(R)-2-Acetamido-N-benzyl-3-methoxypropanamide;(2R)-2-acetamido-N-benzyl-3-methoxy-propanamide;SPM 927;LACOSAMIDE;ADD 243037;Lacoxamide;Lacosamine
- CBNumber:
- CB41011740
- Molecular Formula:
- C13H18N2O3
- Molecular Weight:
- 250.29
- MOL File:
- 175481-36-4.mol
- Modify Date:
- 2024/5/8 15:48:26
| Melting point | 141-143?C |
|---|---|
| alpha | D23 +16.0° (c = 1 in CH3OH) |
| Boiling point | 536.4±50.0 °C(Predicted) |
| Density | 1.120±0.06 g/cm3(Predicted) |
| Flash point | 2℃ |
| storage temp. | Refrigerator |
| solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 2 mg/ml |
| form | A crystalline solid |
| pka | 14.19±0.46(Predicted) |
| InChI | InChI=1S/C13H18N2O3/c1-10(16)15-12(9-18-2)13(17)14-8-11-6-4-3-5-7-11/h3-7,12H,8-9H2,1-2H3,(H,14,17)(H,15,16)/t12-/m1/s1 |
| InChIKey | VPPJLAIAVCUEMN-GFCCVEGCSA-N |
| SMILES | C(NCC1=CC=CC=C1)(=O)[C@H](NC(C)=O)COC |
| CAS DataBase Reference | 175481-36-4 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS02,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H225-H302+H312+H332-H319 | |||||||||
| Precautionary statements | P210-P280-P305+P351+P338 | |||||||||
| Hazard Codes | F,Xn | |||||||||
| Risk Statements | 11-20/21/22-36 | |||||||||
| Safety Statements | 16-26-36/37 | |||||||||
| RIDADR | UN 1648 3 / PGII | |||||||||
| WGK Germany | 2 | |||||||||
| HS Code | 2924296000 | |||||||||
| NFPA 704 |
|
LACOSAMIDE Chemical Properties,Uses,Production
Description
Although epilepsy is a neurological disorder with varying etiology and severity, the common feature is unprovoked, recurring seizures. Whether classified as generalized, involving both cerebral hemispheres, or partial with only localized portions of brain participation at onset, effective treatment relies on accurate assessment of syndrome type to optimally decrease the frequency, duration, and severity of seizures. The latest weapon against partial onset epilepsy is lacosamide, formerly known as harkoseride and erlosamide. The data also indicate that lacosamide binds to collapsing response mediator protein 2 (CRMP2); CRMP2 is involved in neuronal differentiation, control of axonal outgrowth, and possibly epileptogenesis. Furthermore, lacosamide is heralded as having a dual mode of action as it has also displayed efficacy against diabetic neuropathy, possibly as a result of stabilization of neuronal hyperexcitability. Currently,lacosamide is approved as adjunctive treatment of partial onset seizures in patients 17 years or older and is in development as a monotherapy for epilepsy and for neuropathic pain.
Chemical Properties
White to Off-White Solid
Uses
A potent anticonvulsant.
LACOSAMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Jigs Chemical ltd | +919099003427 | Gujarat, India | 239 | 58 | Inquiry |
| SGMR PHARMACEUTICALS PVT LTD | +91-9032001889 +91-9032001889 | Telangana, India | 83 | 58 | Inquiry |
| KARPSCHEM LABORATORIES | +91-7249203006 +91-7249203006 | Maharashtra, India | 786 | 58 | Inquiry |
| Varanous Labs Pvt Ltd | +91-7036248882 +91-7036248882 | Hyderabad, India | 1541 | 58 | Inquiry |
| Metrochem API Private Limited | +91-4069069999 +91-4069069999 | Telangana, India | 78 | 58 | Inquiry |
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Lee Pharma Ltd | +91-9849085929 +91-9849085929 | Hyderabad, India | 42 | 58 | Inquiry |
| Hikal Ltd. | +91-9538444622 +91-8067356100 | Maharashtra, India | 31 | 58 | Inquiry |
| Bajaj Healthcare Ltd | +91-2266177400 +91-2266177400 | Maharashtra, India | 86 | 58 | Inquiry |
| Divis Laboratories Ltd | +91-4066966413 +91-4066966413 | Hyderabad, India | 34 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Jigs Chemical ltd | 58 |
| SGMR PHARMACEUTICALS PVT LTD | 58 |
| KARPSCHEM LABORATORIES | 58 |
| Varanous Labs Pvt Ltd | 58 |
| Metrochem API Private Limited | 58 |
| Hetero Drugs Limited | 58 |
| Lee Pharma Ltd | 58 |
| Hikal Ltd. | 58 |
| Bajaj Healthcare Ltd | 58 |
| Divis Laboratories Ltd | 58 |
Related articles
- What is LACOSAMIDE?Uses,Pharmacodynamics,Mechanism of action,Side effects
- Lacosamide is a functionalized amino acid that has activity in the maximal electroshock seizure test, and is indicated for the....
- Aug 24，2020
175481-36-4(LACOSAMIDE)Related Search:
1of4
chevron_right