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6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE

6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE Structure
CAS No.
1140-81-4
Chemical Name:
6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE
Synonyms
6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE;6-Acetamido-2-methyl-4-hydroxyquinoline;N-Acetyl-4-hydroxy-2-methyl-6-quinolinamine;N-(2-methyl-4-oxo-1H-quinolin-6-yl)acetamide;N-(4-hydroxy-2-Methylquinolin-6-yl)acetaMide;N-(4-Hydroxy-2-methyl-6-quinolinyl)acetamide;Acetamide, N-(4-hydroxy-2-methyl-6-quinolinyl)-;n-(2-Methyl-4-oxo-1,4-dihydroquinolin-6-yl)acetamide
CBNumber:
CB41091481
Molecular Formula:
C12H12N2O2
Molecular Weight:
216.24
MOL File:
1140-81-4.mol
MSDS File:
SDS
Modify Date:
2023/5/24 8:28:53
Request For Quotation

6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE Properties

Melting point >300 °C
Boiling point 496.0±40.0 °C(Predicted)
Density 1.314±0.06 g/cm3(Predicted)
solubility Ethyl Acetate; Toluene
pka 4.29±0.40(Predicted)
form Solid
color Yellow

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P

6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE Chemical Properties,Uses,Production

Uses

N-(4-Hydroxy-2-methyl-6-quinolinyl)acetamide is an intermediate in the synthesis of NSC 23766 (N900280), which is a highly soluble and membrane permeable Rac GTPase inhibitor. NSC 23766 inhibits Rac GTPase by targeting Rac activation by guanine nucleotide exchange factor (GEF). NSC 23766 has been shown to inhibit the anchorage-independent growth and invasion phenotypes of human prostate cancer PC-3 cells.

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 4065, 1948 DOI: 10.1021/ja01192a031

6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE Preparation Products And Raw materials

Raw materials

Ethyl 3-(p-acetamidoanilino)crotonate (E)-Methyl 3-(4-acetaMidophenyliMino)butanoate

Preparation Products

6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE Suppliers

Global( 15)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
CONIER CHEM AND PHARMA LIMITED +8618523575427 China 49391 58 Inquiry
Hebei Guanlang Biotechnology Co., Ltd. +86-19930503259 +86-19930503259 China 18446 58 Inquiry
Amadis Chemical Company Limited 571-89925085 China 131980 58 Inquiry
Shanghai Hao Zhun Biological Technology Co., Ltd. 15800340161 CHINA 6846 58 Inquiry
Shanghai Haohong Pharmaceutical Co., Ltd. 400-400-8210725 4008210725 China 40036 58 Inquiry
Riedel-de Haen AG 800 558-9160 United States 6825 87 Inquiry
Syntastic AB +46 705927309 Sweden 181 38 Inquiry
Alfa Chemistry +1 (201) 478-8534 United States 6824 0 Inquiry
Shanghai Qiao Chemical Science Co., Ltd 021-58892003 China 5906 65 Inquiry
Supplier Advantage
CLEARSYNTH LABS LTD. 58
CONIER CHEM AND PHARMA LIMITED 58
Hebei Guanlang Biotechnology Co., Ltd. 58
Amadis Chemical Company Limited 58
Shanghai Hao Zhun Biological Technology Co., Ltd. 58
Shanghai Haohong Pharmaceutical Co., Ltd. 58
Riedel-de Haen AG 87
Syntastic AB 38
Alfa Chemistry 0
Shanghai Qiao Chemical Science Co., Ltd 65

1140-81-4(6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE)Related Search:

4-HYDROXY-2-METHYLQUINOLINE 4-Hydroxy-2-methylquinoline 4-Quinolinol,6-amino-(9CI) 6-AMINO-2-METHYLQUINOLINE 6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE
6-ACETAMIDO-4-HYDROXY-2-METHYLQUINOLINE N-(4-Hydroxy-2-methyl-6-quinolinyl)acetamide N-Acetyl-4-hydroxy-2-methyl-6-quinolinamine N-(4-hydroxy-2-Methylquinolin-6-yl)acetaMide N-(2-methyl-4-oxo-1H-quinolin-6-yl)acetamide 6-Acetamido-2-methyl-4-hydroxyquinoline Acetamide, N-(4-hydroxy-2-methyl-6-quinolinyl)- n-(2-Methyl-4-oxo-1,4-dihydroquinolin-6-yl)acetamide 1140-81-4