Ravuconazole

CAS No.: 182760-06-1

Chemical Name:: Ravuconazole

Synonyms: Rcz;Er-30346;Aids057176;Bms-207147;The health;Bms-207,147;Aids-057176;Rafconazole;Ravuconazole;Levaconazole

CBNumber:: CB41257944

Molecular Formula:: C22H17F2N5OS

Molecular Weight:: 437.47

MOL File:: 182760-06-1.mol

Modify Date:: 2024/7/2 8:55:07

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Ravuconazole Properties

Melting point	64-66°C
alpha	D24 -29.1° (c = 1.03 in methanol)
Boiling point	674.9±65.0 °C(Predicted)
Density	1.38±0.1 g/cm3(Predicted)
storage temp.	-20°C Freezer
solubility	DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.25 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
form	A crystalline solid
pka	11.62±0.29(Predicted)
color	Off-white to yellow

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P280-P305+P351+P338-P337+P313

NFPA 704

	0
2		0

Ravuconazole Chemical Properties,Uses,Production

Description

Ravuconazole is an orally available triazole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml). Like other azoles, ravuconazole inhibits cytochrome P450 (CYP) isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes. Ravuconazole specifically inhibits sterol 14α-demethylase (CYP51). As this enzyme is also important in the development of trypanosomes, ravuconazole is effective against T. cruzi infections in animal models of Chagas disease.

Chemical Properties

Off-White Solid

Uses

Ergosterol biosynthesis inhibitor. Antifungal.

Ravuconazole Preparation Products And Raw materials

Raw materials

(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)butanethioaMide (αS,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanenitrile 2-Chloro-2',4'-difluoroacetophenone 4-(2-Bromoacetyl)benzonitrile (2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide

3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde (S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile 4-Acetylbenzonitrile

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Preparation Products

Ravuconazole Suppliers

Global( 97)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
AFINE CHEMICALS LIMITED	+86-0571-85134551	China	15395	58	Inquiry
Guangzhou TongYi biochemistry technology Co.,LTD	+8613073028829	China	2996	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
Nanjing Doge Biomedical Technology Co., Ltd	+86-25-58227606 +86-15305155328	China	4128	58	Inquiry
LEAP CHEM CO., LTD.	+86-852-30606658	China	24738	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
AFINE CHEMICALS LIMITED	58
Guangzhou TongYi biochemistry technology Co.,LTD	58
InvivoChem	58
Nanjing Doge Biomedical Technology Co., Ltd	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58

182760-06-1(Ravuconazole)Related Search:

Voriconazole Fosfluconazole

Aids057176 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile Aids-057176 Benzonitrile, 4-[2-[(1R,2R)-2-(2,4-difluro-phenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]- Bms-207,147 Bms-207147 Er-30346 Rcz Benzonitrile, 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]- Ravuconazole, BMS-207147 [R-(R*,R*)]-4-{2-[2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)-propyl]-4-thiazolyl}-benzonitrile BMS-207147/Ravuconazole 4-(2-((2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile The health Ravuconazole inhibit,ER30346,BMS207147,Ravuconazole,BMS 207147,Fungal,ER 30346,Inhibitor Ravuconazole Impurity 1 Levaconazole Rafconazole 182760-06-1 C22H17F2N5OS Aromatics Chiral Reagents Heterocycles Inhibitors Intermediates & Fine Chemicals Pharmaceuticals