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3-Deazauridine

CAS No.: 23205-42-7

Chemical Name:: 3-Deazauridine

Synonyms: NSC-126849;3-deazuridine;3-DEAZAURIDINE;3-DEAZAURIDINE CRYSTALLINE;3Deazauridine,3 Deazauridine;3-Deazauridine,anticancer antiviral;1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone;4-Hydroxy-1-(β-D-ribofuranosyl)-2-pyridone;4-Hydroxy-1-β-D-ribofuranosyl-2(1H)pyridone;4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridone

CBNumber:: CB4125871

Molecular Formula:: C10H13NO6

Molecular Weight:: 243.21

MOL File:: 23205-42-7.mol

Modify Date:: 2023/12/20 10:15:24

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3-Deazauridine Properties

Melting point	233-235°C
Boiling point	569.2±50.0 °C(Predicted)
Density	1.718±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	DMSO (Slightly), Methanol (Slightly), Water (Slightly)
form	Solid
pka	4.50±1.00(Predicted)
color	White to Pale Beige
InChI	InChI=1/C10H13NO6/c12-4-6-8(15)9(16)10(17-6)11-2-1-5(13)3-7(11)14/h1-3,6,8-10,12-13,15-16H,4H2/t6-,8-,9-,10-/s3
InChIKey	CBOKZNLSFMZJJA-FNMQVXAUNA-N
SMILES	[C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=CC(O)=CC1=O \|&1:0,1,3,5,r\|
LogP	-1.693 (est)

SAFETY

Risk and Safety Statements

RTECS	UV1148000

3-Deazauridine Chemical Properties,Uses,Production

Description

3-Deazauridine is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase, which is considered to be the primary mode of action of this nucleoside analog. This compound has been shown to possess in vitro activity against leukemia L1210 tumor cells, Ehrlich ascites tumor cells, Escherichia coli, and Streptococcus faecium. Despite a paucity of clinical attention given to this drug as a single agent, it has generated much enthusiasm as a biological response modulator because of its synergistic effect with several antitumor agents, including Cytosine Arabinoside, 5-aza-2'-deoxycytidine, 5-azacytidine, thymidine and D-galactosamine. However, only the cytosine arabinoside/3-Deazauridine combination has been explored clinically[1-2].

Uses

Antimetabolite antiviral dosing regimen for hepatitis C virus or flaviviridae therapy.

References

[1] W J Moriconi, S Taylor, M Slavik. “3-Deazauridine (NSC 126849): an interesting modulator of biochemical response.” Investigational New Drugs 4 1 (1986): 67–84.
[2] W M Shannon, F M Schabel, G Arnett. “3-Deazauridine: inhibition of ribonucleic acid virus-induced cytopathogenic effects in vitro.” Antimicrobial Agents and Chemotherapy 2 3 (1972): 159–63.

3-Deazauridine Preparation Products And Raw materials

Raw materials

Preparation Products

3-Deazauridine Suppliers

Global( 74)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
Biokemix	+91 (40) 6662-6366	New Delhi, India	487	50	Inquiry
PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD	0371-55159968 18137130222	China	512	58	Inquiry
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	China	10311	58	Inquiry
Career Henan Chemica Co	+86-0371-86658258 +8613203830695	China	30250	58	Inquiry
BOC Sciences	16314854226; +16314854226	United States	19743	58	Inquiry
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	China	9980	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry
Wuhan Fortuna Chemical Co.,Ltd	+8618007136271	China	5964	58	Inquiry
ROSEWA HOLDING GROUP CO.,LIMITED	+86-023-62871537	China	2844	58	Inquiry

Supplier	Advantage
Biokemix	50
PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD	58
Shenzhen Nexconn Pharmatechs Ltd	58
Career Henan Chemica Co	58
BOC Sciences	58
NewCan Biotech Limited	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Wuhan Fortuna Chemical Co.,Ltd	58
ROSEWA HOLDING GROUP CO.,LIMITED	58

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4-HYDROXY-1-BETA-D-RIBOFURANOSYL-2[1H]PYRIDONE 3-DEAZAURIDINE 3-deazuridine 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridinon 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridinone 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridon 3-DEAZAURIDINE CRYSTALLINE 1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone 4-Hydroxy-1-(β-D-ribofuranosyl)-2-pyridone 4-Hydroxy-1-β-D-ribofuranosyl-2(1H)pyridone 4-Hydroxy-1-(β-D-ribofuranosyl)-1,2-dihydropyridin-2-one 4-Hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone NSC-126849 4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridone 1-[(2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-2-HYDROXYPYRIDIN-4-ONE 2(1H)-Pyridinone, 4-hydroxy-1-β-D-ribofuranosyl- 3-Deazauridine, 4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, 3-DAU, NSC 126849 2(1H)-Pyridinone,4-hydroxy-1-b-D-ribofuranosyl- 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxypyridin-2(1H)-one 3-Deazauridine,4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, synthetase inhibitor, anticancer drug, NSC126849, 3D2U 4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, NSC126849 3Deazauridine,3 Deazauridine 3-Deazauridine,anticancer antiviral 23205-42-7 232005-42-7 20235-47-2 C10H13NO6 Bases & Related Reagents Heterocycles Intermediates & Fine Chemicals Nucleotides Pharmaceuticals