5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE

CAS No.: 256414-75-2

Chemical Name:: 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE

Synonyms: SW2871;SEW 2871;BUTTPARK 82\12-95;S1P? Receptor Agonist, SEW2871;SPHINGOSINE-1-PHOSPATE, RECEPTOR S1P1 AGONIST;S1P Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem;5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE;5-[4-Phenyl-5-(trifluoromethyl)thien-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole;1,2,4-Oxadiazole, 5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]-;5-[4-PHENYL-5-(TRIFLUOROMETHYL)THIOPHEN-2-YL]-3-[3-(TRIFLUOROMETHYL)PHENYL]1,2,4-OXADIAZOLE

CBNumber:: CB4131568

Molecular Formula:: C20H10F6N2OS

Molecular Weight:: 440.36

MOL File:: 256414-75-2.mol

Modify Date:: 2023/6/30 15:45:59

Request For Quotation

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Properties

Melting point	94.5-95.3 °C
Boiling point	490.3±55.0 °C(Predicted)
Density	1.415±0.06 g/cm3(Predicted)
storage temp.	2-8°C
solubility	DMSO: 17 mg/mL
form	solid
pka	-3.48±0.43(Predicted)
color	white
InChIKey	OYMNPJXKQVTQTR-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS06

Signal word

Danger

Hazard statements

H300

Precautionary statements

P264-P270-P301+P310-P321-P330-P405-P501

Hazard Codes

Risk Statements

Safety Statements

RIDADR

UN 2811 6.1/PG 3

WGK Germany

HS Code

2934999090

NFPA 704

	1
2		0

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	S3944	SEW2871 ≥98% (HPLC), solid	256414-75-2	1MG	₹22505.18	2022-06-14	Buy
Sigma-Aldrich(India)	S3944	SEW2871 ≥98% (HPLC), solid	256414-75-2	5MG	₹101895.73	2022-06-14	Buy

Product number	Packaging	Price	Buy
S3944	1MG	₹22505.18	Buy
S3944	5MG	₹101895.73	Buy

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Chemical Properties,Uses,Production

Description

Sphingosine-1-phosphate receptor 1 (S1P₁) is one of five high affinity G protein-coupled S1P receptors which mediate a variety of effects including lymphocyte recirculation in the blood. Non-selective S1P receptor agonists, such as FTY720, produce clinical immunosuppression useful for preventing transplant rejection and treating autoimmune diseases. However, they also cause bradycardia by activating S1P₃, the receptor responsible for regulation of heart rate. SEW2871 is a selective S1P₁ receptor agonist in both human and mouse that is not active at the S1P_2-5 receptors. SEW2871, therefore, suppresses the immune response by decreasing the number of lymphocytes circulating in blood without causing bradycardia.

Uses

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE is used as medicament for treating and/or preventing cardiovascular conditions in patients with Fabry disease.

Biological Activity

Novel, potent and selective sphingosine-1-phosphate 1 (S1P 1 ) receptor agonist. Activates S1P 1 receptor with an EC 50 of 13 nM, but does not activate S1P 2 , S1P 3 , S1P 4 or S1P 5 receptors at concentrations up to 10 μ M. Cell-permeable and active in vivo .

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Suppliers

Global( 102)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CHEMSWORTH	+91-261-2397244	New Delhi, India	6707	30	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32835	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29820	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	19892	58	Inquiry
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LEAP CHEM CO., LTD.	+86-852-30606658	China	24738	58	Inquiry
Aladdin Scientific	+1-+1(833)-552-7181	United States	57511	58	Inquiry
Amadis Chemical Company Limited	571-89925085	China	131980	58	Inquiry
Shanghai Minmin Biotechnology Co., Ltd.	18021003406	CHINA	6530	58	Inquiry

Supplier	Advantage
CHEMSWORTH	30
CLEARSYNTH LABS LTD.	58
ATK CHEMICAL COMPANY LIMITED	60
career henan chemical co	58
TargetMol Chemicals Inc.	58
InvivoChem	58
LEAP CHEM CO., LTD.	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Shanghai Minmin Biotechnology Co., Ltd.	58

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE Spectrum

5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE(256414-75-2)MS

256414-75-2(5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE)Related Search:

Benzotribromide 2,4,6-Trimethylaniline 2-(TRIFLUOROMETHYL)THIOPHENE 5-METHYL-3-PHENYL-1,2,4-OXADIAZOLE 3,5-DIMETHYL-1,2,4-OXADIAZOLE

2,3,5-Trimethylthiophene 3-PHENYLTHIOPHENE 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE

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SEW 2871 SPHINGOSINE-1-PHOSPATE, RECEPTOR S1P1 AGONIST SW2871 5-[4-PHENYL-5-(TRIFLUOROMETHYL)-2-THIENYL]-3-[3-(TRIFLUOROMETHYL)PHENYL]-1,2,4-OXADIAZOLE 5-[4-PHENYL-5-(TRIFLUOROMETHYL)THIOPHEN-2-YL]-3-[3-(TRIFLUOROMETHYL)PHENYL]1,2,4-OXADIAZOLE BUTTPARK 82\12-95 SEW-2871, 5-[4-Phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 1,2,4-oxadiazole 5-[4-Phenyl-5-(trifluoromethyl)thien-2-yl]-3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazole S1P? Receptor Agonist, SEW2871 S1P Receptor Agonist, SEW2871 - CAS 256414-75-2 - Calbiochem 1,2,4-Oxadiazole, 5-[4-phenyl-5-(trifluoromethyl)-2-thienyl]-3-[3-(trifluoromethyl)phenyl]- 256414-75-2 C20H10F6N2OS Lysophospholipid receptor and related Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds