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marcfortine A

marcfortine A Structure
CAS No.
75731-43-0
Chemical Name:
marcfortine A
Synonyms
UK 111866;marcfortine A;Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,2'(3'H)-[1H,4H-3a,9a](iminomethano)cyclopenta[b]quinolizine]-9,11'(10H)-dione, 6',7',8',9',10',10'a-hexahydro-1',1',4,4,12'-pentamethyl-, (2'R,3'aS,9'aS,10'aS)-
CBNumber:
CB41323193
Molecular Formula:
C28H35N3O4
Molecular Weight:
477.602
MOL File:
75731-43-0.mol
Modify Date:
2023/5/21 10:59:17
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marcfortine A Properties

Melting point 245 °C
Boiling point 660.6±55.0 °C(Predicted)
Density 1.33±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Methanol: soluble
form A solid
pka 12.05±0.60(Predicted)

marcfortine A Chemical Properties,Uses,Production

Description

Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM)., Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.

Uses

Marcfortine A is an indole alkaloid, isolated from Aspergillus and Pencillium species, with potent nematocidal activity. The marcfortines are structurally related to paraherquamides and are thought to act by blocking cholinergic neuromuscular transmission.

marcfortine A Preparation Products And Raw materials

Raw materials

Preparation Products

marcfortine A Suppliers

Global( 16)Suppliers
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BOC Sciences 58
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TargetMol Chemicals Inc. 58
Shenzhen Polymeri Biochemical Technology Co., Ltd. 58
Beijing Fubo Biotechnology Co., Ltd. 58
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Shanghai Bosheng Biotechnology Co., Ltd. 58
Beijing Bolide Biotechnology Co., Ltd. 58
Beijing Sizhengbai Biotechnology Co., Ltd. 58
Lynnchem 58

75731-43-0(marcfortine A)Related Search:

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marcfortine A UK 111866 Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,2'(3'H)-[1H,4H-3a,9a](iminomethano)cyclopenta[b]quinolizine]-9,11'(10H)-dione, 6',7',8',9',10',10'a-hexahydro-1',1',4,4,12'-pentamethyl-, (2'R,3'aS,9'aS,10'aS)- 75731-43-0