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OXOTREMORINE

OXOTREMORINE Structure
CAS No.
70-22-4
Chemical Name:
OXOTREMORINE
Synonyms
oxotremorin;OXOTREMORINE;2’-oxopyrrolidino-1-pyrrolidino-4-butyne;1-(4-pyrrolidin-1-ylbut-2-ynyl)-2-pyrrolidone;1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidinon;1-[4-(1-PYRROLIDINYL)-2-BUTYNYL]-2-PYRROLIDINONE;1-(4-(pyrrolidin-1-yl)but-2-ynyl)pyrrolidin-2-one;1-[4-(Pyrrolidin-1-yl)-2-butynyl]pyrrolidin-2-one;1-(4-(Pyrrolidin-1-yl)but-2-yn-1-yl)pyrrolidin-2-one;1-(2-Oxopyrrolidin-1-yl)-4-(pyrrolidin-1-yl)-2-butyne
CBNumber:
CB4133678
Molecular Formula:
C12H18N2O
Molecular Weight:
206.28
MOL File:
70-22-4.mol
Modify Date:
2023/5/4 17:34:41
Request For Quotation

OXOTREMORINE Properties

Melting point <25 °C
Boiling point 124 °C0.1 mm Hg(lit.)
Density 1 g/mL at 25 °C(lit.)
refractive index n20/D 1.517(lit.)
Flash point 113 °C
storage temp. 2-8°C
solubility H2O: 50 mg/mL
form liquid
pka 8.29±0.20(Predicted)
color clear, light yellow
Merck 13,7020

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS06
Signal word  Danger
Hazard statements  H300-H314
Precautionary statements  P264-P270-P301+P310-P321-P330-P405-P501-P260-P264-P280-P301+P330+P331-P303+P361+P353-P363-P304+P340-P310-P321-P305+P351+P338-P405-P501
Hazard Codes  T+,C
Risk Statements  28-34
Safety Statements  26-36/37/39-45
RIDADR  UN 2810 6.1/PG 1
WGK Germany  3
RTECS  UY5950100
F  10-23
HazardClass  6.1(a)
PackingGroup  I
Toxicity LD50 ipr-rat: 4400 mg/kg TXAPA9 14,67,69

OXOTREMORINE Chemical Properties,Uses,Production

General Description

Oxotremorine [1-(-pyrrolidono)-4-pyrrolidino-2-butyne] has been regarded as a CNS muscarinicstimulant. Its action on the brain produces tremors inexperimental animals. It increases ACh brain levels in ratsup to 40% and has been studied as a drug in the treatment ofAlzheimer disease. Although earlier studies suggested thatthis approach of elevating levels of ACh to treat Alzheimerdisease is useful, this belief was highly disputed by manyresearchers.

Clinical Use

Nevertheless, oxotremorine, as a cholinergicagonist, facilitates memory storage. These findings haveserved as important leads in the development of agents usefulin treating Alzheimer disease. Although it possessesgroups that do not occur in other highly active muscarinicagents, oxotremorine’s trans conformation shows that distancesbetween possible active centers correspond with (+)-muscarine.

Safety Profile

Poison by ingestion and intraperitoneal routes. Moderately toxic by intravenous route. When heated to decomposition it emits toxic fumes of NOx.

OXOTREMORINE Preparation Products And Raw materials

Raw materials

Preparation Products

OXOTREMORINE Suppliers

Global( 17)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Finetech Industry Limited +86-27-87465837 +8618971612321 China 9640 58 Inquiry
Nanjing Bicbiotechnology Co., Ltd +86-2552131256 +86-18251840740 China 6000 58 Inquiry
Finetech Industry Limited 027-87465837 19945049750 China 9649 58 Inquiry
Pfaltz & Bauer, Inc. (800) 225-5172 United States 6830 72 Inquiry
Research Organics Inc. 800 321-0570 United States 1324 72 Inquiry
Tocris Bioscience +44 (0) 117 916 3333 United Kingdom 5729 77 Inquiry
Service Chemical Inc. 888-895-6920 Germany 6373 71 Inquiry
3B Scientific Corporation 847.281.9822 United States 6744 47 Inquiry
Advance Scientific & Chemical (954) 327-0900 United States 6434 71 Inquiry
Lanospharma Laboratories Co.,Ltd 13440048448 China 6343 56 Inquiry
Supplier Advantage
Finetech Industry Limited 58
Nanjing Bicbiotechnology Co., Ltd 58
Finetech Industry Limited 58
Pfaltz & Bauer, Inc. 72
Research Organics Inc. 72
Tocris Bioscience 77
Service Chemical Inc. 71
3B Scientific Corporation 47
Advance Scientific & Chemical 71
Lanospharma Laboratories Co.,Ltd 56

OXOTREMORINE Spectrum

OXOTREMORINE(70-22-4)MSOXOTREMORINE(70-22-4)IR1

70-22-4(OXOTREMORINE)Related Search:

Diethylacetamide N,N-Dimethylacetamide N,N-Dimethylformamide PROPARGYLAMINE 1-Methylpyrrolidine
1-PROP-2-YN-1-YLPYRROLIDINE 2-Pyrrolidinone N,N-Dimethylpropionamide 2-Butyne N,N-Diethylpropargylamine
OXOTREMORINE N,N-Diethylformamide 1-DIMETHYLAMINO-2-PROPYNE N-METHYLPROPARGYLAMINE 1-Ethyl-2-pyrrolidone
N-ETHYLPROPIONAMIDE 1-PROP-2-YNYL-PYRROLIDIN-2-ONE N-ETHYLPYRROLIDINE
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2’-oxopyrrolidino-1-pyrrolidino-4-butyne oxotremorin 1-(4-(pyrrolidin-1-yl)but-2-ynyl)pyrrolidin-2-one 1-(2-Oxo-pyrrolidin-1-yl)-4-(pyrrolidin-1-yl)-2-butyne 1-(2-Oxopyrrolidin-1-yl)-4-(pyrrolidin-1-yl)-2-butyne 1-[4-(Pyrrolidin-1-yl)-2-butynyl]pyrrolidin-2-one 1-(4-pyrrolidin-1-ylbut-2-ynyl)-2-pyrrolidone 1-(4-(Pyrrolidin-1-yl)but-2-yn-1-yl)pyrrolidin-2-one 1-[4-(1-PYRROLIDINYL)-2-BUTYNYL]-2-PYRROLIDINONE OXOTREMORINE 1-(4-(1-pyrrolidinyl)-2-butynyl)-2-pyrrolidinon 2-Pyrrolidinone, 1-[4-(1-pyrrolidinyl)-2-butyn-1-yl]- 70-22-4