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narciclasine

narciclasine Structure
CAS No.
29477-83-6
Chemical Name:
narciclasine
Synonyms
rciclasin;NSC 266535;Narciclasin;BRN 1087400;Lycorcidinol;narciclasine;Lycoricidin-A;Narciclasine, 99.9%;(13β)-1,19-Didehydro-2α,3β,4β,7-tetrahydroxy-11,12-dinor-5,19-secocrinan-6-one;3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one
CBNumber:
CB41341322
Molecular Formula:
C14H13NO7
Molecular Weight:
307.26
MOL File:
29477-83-6.mol
MSDS File:
SDS
Modify Date:
2023/9/4 15:51:00
Request For Quotation

narciclasine Properties

Melting point 250-252℃
Boiling point 447.77°C (rough estimate)
Density 1.85±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 1.5300 (estimate)
storage temp. Store at -20°C
solubility DMSO: ≥10mg/mL
pka 7.72±0.70(Predicted)
form Solid
color white to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310+P330
Hazard Codes  Xn
Risk Statements  46
Safety Statements  36

narciclasine price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) SML2805 Narciclasine ≥98% (HPLC) 29477-83-6 1MG ₹13693.63 2022-06-14 Buy
Sigma-Aldrich(India) SML2805 Narciclasine ≥98% (HPLC) 29477-83-6 5MG ₹56246.7 2022-06-14 Buy
Product number Packaging Price Buy
SML2805 1MG ₹13693.63 Buy
SML2805 5MG ₹56246.7 Buy

narciclasine Chemical Properties,Uses,Production

Description

Narciclasine is a plant growth inhibitor that can be isolated from Narcissus bulbs. At 1 μM, it has been shown to induce apoptosis-mediated cytotoxicity in human cancer cells in vitro but not in normal fibroblasts. Narciclasine has been shown to regulate the Rho/Rho kinase/LIM kinase/cofilin signaling pathway by increasing GTPase RhoA activity, as well as inducing actin stress fiber formation in a RhoA-dependent manner.

Uses

Narciclasine is reasonably abundant in some Narcissus spp. and has served as a very useful intermediate for synthetic conversion into (+)-pancratistatin and to conduct a series of structure–activity relationship studies . Bicolorine, another member of the narciclasine series, is an unusual, completely aromatized quaternary alkaloid with an N-methyl group.

Definition

ChEBI: A natural product found in Narcissus pseudonarcissus.

References

Ceriotti., Nature, 213,595 (1967)
Piozzi et al., Tetrahedron, 24, 1119 (1968)
Revised structure: Mondon, Krohn., Tetrahedron Lett., 2123 (1970)
Savona, Piozzi, Marino., Chern. Cornrnun., 1006 (1970)
Absolute configuration: Fuganti, Mazza.,J. Chern. Soc., Chern. Cornrnun., 239 (1972)
Crystal structure: Immirzi, Fuganti., J. Chern. Soc., Chern. Cornrnun., 240 (1972)
Stereochemistry: Mondon, Krohn., Tetrahedron Lett., 2085 (1972)

narciclasine Preparation Products And Raw materials

Raw materials

Preparation Products

narciclasine Suppliers

Global( 99)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Chengdu Biopurify Phytochemicals Ltd. +86-28-82633860 +86-18080483897 China 3424 58 Inquiry
BOC Sciences +1-631-485-4226 United States 19553 58 Inquiry
Neostar United (Changzhou) Industrial Co., Ltd. +86-519-519-85557386 China 11667 58 Inquiry
InvivoChem +1-708-310-1919 +1-13798911105 United States 6393 58 Inquiry
LEAPCHEM CO., LTD. +86-852-30606658 China 43348 58 Inquiry
Shanghai Acmec Biochemical Technology Co., Ltd. +undefined18621343501 China 33350 58 Inquiry
Aladdin Scientific +1-+1(833)-552-7181 United States 52927 58 Inquiry
Hubei CuiRan Biotechnology Co., Ltd. 181-86211184 18162791556 China 4351 58 Inquiry
InvivoChem 13549236410 China 6749 58 Inquiry
SHANGHAI ZZBIO CO., LTD. 18019219489 19921389125 China 12064 58 Inquiry
Supplier Advantage
Chengdu Biopurify Phytochemicals Ltd. 58
BOC Sciences 58
Neostar United (Changzhou) Industrial Co., Ltd. 58
InvivoChem 58
LEAPCHEM CO., LTD. 58
Shanghai Acmec Biochemical Technology Co., Ltd. 58
Aladdin Scientific 58
Hubei CuiRan Biotechnology Co., Ltd. 58
InvivoChem 58
SHANGHAI ZZBIO CO., LTD. 58

narciclasine Spectrum

narciclasine(29477-83-6)1HNMR

29477-83-6(narciclasine)Related Search:

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narciclasine (13β)-1,19-Didehydro-2α,3β,4β,7-tetrahydroxy-11,12-dinor-5,19-secocrinan-6-one (2S)-3,4,4aβ,5-Tetrahydro-2α,3β,4β,7-tetrahydroxy[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one Lycorcidinol (2S,3R,4S,4aR)-3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one (2S-(2-alpha,3-beta,4-beta,4a-beta))-3,4,4a,5-tetrahydro-2,3,4,7-tetrahydroxy-(1,3)Dioxolo(4,5-j)phenanthridin-6(2H)-one 3,4,4a,5-Tetrahydro-2,3,4,7-tetrahydroxy-(1,3)dioxolo(4,5-j)phenanthridin-6(2H)-one BRN 1087400 Lycoricidin-A NSC 266535 Narciclasin Narciclasine, 99.9% rciclasin [1,3]Dioxolo[4,5-j]phenanthridin-6(2H)-one, 3,4,4a,5-tetrahydro-2,3,4,7-tetrahydroxy-, (2S,3R,4S,4aR)- Rho-associated kinase,ROCK,inhibit,Inhibitor,ROK,Narciclasine,Rho-associated protein kinase,Rho-kinase (2S,3R,4S,4aR)-2,3,4,7-Tetrahydroxy-3,4,4a,5-tetrahydro-[1,3]dioxolo[4,5-j]phenanthridin-6(2H)-one 29477-83-6