UK 1

UK 1 Structure
CAS No.
151271-53-3
Chemical Name:
UK 1
Synonyms
UK 1;UK 1 (cytotoxin);2'-(2-Hydroxyphenyl)-[2,4'-bibenzoxazole]-4-carboxylic acid methyl ester;[2,4'-Bibenzoxazole]-4-carboxylic acid, 2'-(2-hydroxyphenyl)-, methyl ester
CBNumber:
CB41370041
Molecular Formula:
C22H14N2O5
Molecular Weight:
386.36
MOL File:
151271-53-3.mol
MSDS File:
SDS
Modify Date:
2023/6/30 15:45:59

UK 1 Properties

Melting point 209-210℃
Boiling point 541.4±30.0 °C(Predicted)
Density 1.396±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO;Soluble in dimethyl formamide
form solid
pka 8.55±0.30(Predicted)
color White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302+H332-H319
Precautionary statements  P261-P264-P270-P271-P280-P301+P312-P330-P304+P340-P305+P351+P338-P337+P313-P501
NFPA 704
0
3 0

UK 1 Chemical Properties,Uses,Production

Uses

UK-1 is an unusual bis-benzoxazole metabolite isolated from a species of Streptomyces. UK-1 exhibits good antitumour activity but is devoid of antimicrobial activity. UK-1 acts as a magnesium ion-dependent, DNA binding agent and inhibitor of human topoisomerase II.

UK 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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UK 1 UK 1 (cytotoxin) 2'-(2-Hydroxyphenyl)-[2,4'-bibenzoxazole]-4-carboxylic acid methyl ester [2,4'-Bibenzoxazole]-4-carboxylic acid, 2'-(2-hydroxyphenyl)-, methyl ester 151271-53-3