kobusine
- CAS No.
- 27530-78-5
- Chemical Name:
- kobusine
- Synonyms
- kobusine;Hetisan-11β,15β-diol;Hetisan-11,15-diol, (11β,15β)-
- CBNumber:
- CB41376856
- Molecular Formula:
- C20H27NO2
- Molecular Weight:
- 313.43
- MOL File:
- 27530-78-5.mol
kobusine Chemical Properties,Uses,Production
Description
Obtained by Suginome and Shimanouti from the precipitation liquors of crude jesaconitine from Aconitum sachalinense, Fr. Schmidt, this alkaloid crystallizes from Me2CO in the rhombic-bisphenoidal system and has (a:b:c = 1.0736: I: 0.9811). It furnishes crystalline salts: the hydrobromide crystallizes as the mono_x0002_hydrate, m.p. 288°C (dec.); [α]22D + 40.68° (H20); hydrochloride (1.5 H20) has m.p. 300°C (dec.);[α]21Dl + 41.4° (H20); perchlorate, m.p. 185-7°C (dec.) although a value of 220°C has also been recorded for this salt; platinichloride, m.p. 262°C (dec.); picrate, m.p. 282-4°C (dec.) and methiodide, m.p. 287°C (dec.). The alkaloid forms a diacetyl derivative, m.p. 139-140°C and catalytic reduction followed by acetylation yields a triacetyltetrahydrokobusine, m.p. 183-4°C (dec.). The alkaloid cannot be hydrolyzed and is non-toxic.
References
Suginome, Shimanouti., Annalen, 545, 220 (1940)
Okamoto., Chern. Pharm. Bull. (Tokyo), 7,44 (1959)
Natsume., ibid, 7,539 (1959)
kobusine Preparation Products And Raw materials
Raw materials
Preparation Products
kobusine Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| CHEMICAL LAND21 | 82- 2 -783 - 8063 | South Korea | 6315 | 74 | Inquiry |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| CHEMICAL LAND21 | 74 |