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Xanomeline

CAS No.: 131986-45-3

Chemical Name:: Xanomeline

Synonyms: XANOMELINE;Memcor;Lomeron;LY-246708;NNC-11-0232;3-(Hexyloxy);Xanomeline(LY-246708);Xanomeline L-tartrate hydrate;Xanomeline L-tartrate hydrate >=98% (HPLC);-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)

CBNumber:: CB4144966

Molecular Formula:: C14H23N3OS

Molecular Weight:: 281.42

MOL File:: 131986-45-3.mol

MSDS File:: SDS

Modify Date:: 2024/5/8 14:34:25

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Xanomeline Properties

Boiling point	397.0±42.0 °C(Predicted)
Density	1.101±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,2-8°C
solubility	H2O: soluble10mg/mL, clear (warmed)
form	powder
pka	7.34±0.40(Predicted)
color	off-white
InChIKey	JOLJIIDDOBNFHW-UHFFFAOYSA-N

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS06
Signal word	Danger
Hazard statements	H301
Precautionary statements	P264-P270-P301+P312-P330
WGK Germany	3

Xanomeline price More Price(1)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	X2754	Xanomeline L-tartrate hydrate ≥98% (HPLC)	131986-45-3	25MG	₹103432.88	2022-06-14	Buy

Product number	Packaging	Price	Buy
X2754	25MG	₹103432.88	Buy

Xanomeline Chemical Properties,Uses,Production

Description

Xanomeline is used as a potent and selective muscarinic type 1 and type 4 (M1/M4) receptor agonist to increase neuronal excitability. Xanomeline is used in studies of neurological disorders such as Alzheimer's disease and schizophrenia. However, development of the drug was halted due to severe cholinergic adverse effects. Currently, xanomeline-trospium (KarXT) (a peripheral cholinergic antagonist) has been explored for the treatment of schizophrenia and a New Drug Application has been filed with the FDA, with a decision on whether it will be approved or not expected on 26 September 2024.

Uses

Alzheimer’s disease treatment (cholinergic agonist).

Mechanism of action

Xanomeline's mechanism of action is is to rebalance key neurotransmitter circuits, including acetylcholine, dopamine and glutamate, which are disrupted in schizophrenia and related disorders.

Xanomeline Preparation Products And Raw materials

Raw materials

3-PYRIDYLACETONITRILE Sodium borohydride Sodium hexylate Iodomethane Praseodymium(III) nitrate hexahydrate

Formamide

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Preparation Products

Xanomeline Suppliers

Global( 72)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CHEMSWORTH	+91-261-2397244	New Delhi, India	6707	30	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
Finetech Industry Limited	+86-27-87465837 +8618971612321	China	9626	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	26415	58	Inquiry
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	China	10522	58	Inquiry
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	China	3136	58	Inquiry
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	China	8474	58	Inquiry
LEAPCHEM CO., LTD.	+86-852-30606658	China	43348	58	Inquiry

Supplier	Advantage
CHEMSWORTH	30
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
Finetech Industry Limited	58
career henan chemical co	58
Dideu Industries Group Limited	58
Zhejiang J&C Biological Technology Co.,Limited	58
Nantong HI-FUTURE Biology Co., Ltd.	58
Wuhan Topule Biopharmaceutical Co., Ltd	58
LEAPCHEM CO., LTD.	58

131986-45-3(Xanomeline)Related Search:

(-)-Huperzine A Donepezil SABCOMELINE 1,2,5-THIADIAZOL-3-OL 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE

3-[4-(Hexy loxy)-1，2，5-thiadiazol-3-y1]-1，2，5，6-tetrahydro-1-methylpyridine 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE Lomeron LY-246708 Memcor NNC-11-0232 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole Xanomeline L-tartrate hydrate 3-(Hexyloxy) -4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl) 3-Hexoxy-4-(1-methyl-3,6-dihydro-2H-pyridin-5-yl)-1,2,5-thiadiazole Pyridine, 3-[4-(hexyloxy)-1,2,5-thiadiazol-3-yl]-1,2,5,6-tetrahydro-1-methyl- Xanomeline L-tartrate hydrate >=98% (HPLC) 5-(4-HEXYLOXY-[1,2,5]THIADIAZOL-3-YL)-1-METHYL-1,2,3,6-TETRAHYDRO-PYRIDINE USP/EP/BP XANOMELINE Xanomeline(LY-246708) 3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydro-3-pyridyl)-1,2,5-thiadiazole 131986-45-3 C14H23N3OS