AC-YVAD-CHO
- CAS No.
- 143313-51-3
- Chemical Name:
- AC-YVAD-CHO
- Synonyms
- YVAD-CHO;L-709049;AC-YVAD-CHO;ICE INHIBITOR;ICE INHIBITOR I;AC-YVAD-ALDEHYDE;TYR-VAL-ALA-ASP-CHO;CASPASE INHIBITOR I;BIOTINYL-AC-YVAD-CHO;ACETYL-YVAD-ALDEHYDE
- CBNumber:
- CB4158149
- Molecular Formula:
- C23H32N4O8
- Molecular Weight:
- 492.52
- MOL File:
- 143313-51-3.mol
- MSDS File:
- SDS
- Modify Date:
- 2024/7/2 8:55:08
| Boiling point | 937.7±65.0 °C(Predicted) |
|---|---|
| Density | 1.276±0.06 g/cm3(Predicted) |
| storage temp. | −20°C |
| solubility |
DMF:30.0(Max Conc. mg/mL);60.91(Max Conc. mM) DMSO:30.0(Max Conc. mg/mL);60.91(Max Conc. mM) Ethanol:30.0(Max Conc. mg/mL);60.91(Max Conc. mM) PBS (pH 7.2):5.0(Max Conc. mg/mL);10.15(Max Conc. mM) |
| form | Powder |
| pka | 4.20±0.10(Predicted) |
| color | White to off-white |
| Sensitive | Moisture Sensitive |
AC-YVAD-CHO price More Price(2)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 400010 | Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is prim | 143313-51-3 | 1MG | ₹12829.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 400010 | Caspase-1 Inhibitor I - CAS 143313-51-3 - Calbiochem The Caspase-1 Inhibitor I, also referenced under CAS 143313-51-3, controls the biological activity of Caspase-1. This small molecule/inhibitor is prim | 143313-51-3 | 5MG | ₹41830 | 2022-06-14 | Buy |
AC-YVAD-CHO Chemical Properties,Uses,Production
Description
Ac-YVAD-CHO is an inhibitor of caspase-1/interleukin-1β converting enzyme (ICE; Ki = 0.76 nM) and an acetylated form of the caspase-1 inhibitor YVAD-CHO . It is selective for caspase-1 over caspase-4, -5, -8, -9, and -10 (Kis = 163-970 nM), as well as over caspase-2, -3, -6, and -7 (Kis = >10,000 nM for all). It inhibits activation of caspase-1 and IL-1β in a cell-free assay using LPS-treated THP-1 cell homogenates when used at a concentration of 5 μM. Ac-YVAD-CHO (12.5 μmol/kg) reduces pancreatic levels of IL-18 and serum levels of IL-1β, as well as reduces pyroptosis of pancreatic cells, in a mouse model of cerulein-induced acute pancreatitis but does not decrease pancreatic expression of NOD-like receptor protein 3 (NLRP3). It increases susceptibility to lethal E. coli infection but prevents LPS-induced death in C3H/HeN mice when administered at doses of 5 and 10 mg/kg, respectively.
Uses
A potent, specific, and reversible inhibitor of caspases-1, -4 and -5
AC-YVAD-CHO Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 92)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | China | 10312 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 24639 | 58 | Inquiry |
| Nextpeptide Inc | +86-0571-81612335 +8613336028439 | China | 19915 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
| Nanjing TGpeptide | +86-13347807150 +86-13347807150 | China | 3279 | 58 | Inquiry |
| Zhejiang Hangyu API Co., Ltd | +8617531972939 | China | 2944 | 58 | Inquiry |
| Aladdin Scientific | +1-+1(833)-552-7181 | United States | 52927 | 58 | Inquiry |
| DONBOO AMINO ACID COMPANY | +8613063595538 | China | 9365 | 58 | Inquiry |
143313-51-3(AC-YVAD-CHO)Related Search:
N-acetyl-N-methyl-L-tyrosyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-L-Alaninamide
AC-TYR-VAL-LYS(BIOTINYL)-ASP-2,6-DIMETHYLBENZOYLOXYMETHYLKETONE
ASN-GLU-ALA-TYR-VAL-HIS-ASP-ALA-PRO-VAL-ARG-SER-LEU-ASN
AC-YVAD-AFC
DABCYL-TYR-VAL-ALA-ASP-ALA-PRO-VAL-EDANS
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N-ACETYL-L-TYROSYL-L-VALYL-N-[(1S)-2-CARBOXYL-1-FORMYLETHYL]-L-ALANINAMIDE
N-ACETYL-TYR-VAL-ALA-ASP-CHO (ALDEHYDE)
N-ACETYL-TYR-VAL-ALA-GLU-AL
N-AC-TYR-VAL-ALA-ASP-CHO
N-ACETYL-ALA-ALA-VAL-ALA-LEU-LEU-PRO-ALA-VAL-LEU-LEU-ALA-LEU-LEU-ALA-PRO-TYR-VAL-ALA-ASP-CHO (ALDEHYDE)
TYR-VAL-ALA-ASP-CHO
YVAD-CHO
ICE INHIBITOR
ICE INHIBITOR I
IL-1BETA CONVERTING ENZYME (ICE) INHIBITOR I
IL-1BETA CONVERTING ENZYME INHIBITOR I
IL-1BETA CONVERTING ENZYME INHIBITOR
L-709049
CASPASE INHIBITOR I
CASPASE 1 (ICE) INHIBITOR I
CASPASE-1 INHIBITOR (ALDEHYDE)
CASPASE-1 INHIBITOR I
CELL-PERMEABLE YVAD-CHO
BIOTINYL-AC-YVAD-CHO
BIOTINYL-AC-TYR-VAL-ALA-ASP-CHO
ACETYL-TYR-VAL-ALA-ASP-ALDEHYDE
ACETYL-YVAD-ALDEHYDE
ACETYL-L-TYROSYL-L-VALYL-L-ALANYL-L-ASPART-1-AL
AC-TYR-VAL-ALA-ASP-H (ALDEHYDE)
AC-YVAD-ALDEHYDE
AC-YVAD-CHO
AC-TYR-VAL-ALA-ASP-ALDEHYDE
AC-TYR-VAL-ALA-ASP-ALDEHYDE (PSEUDO ACID)
AC-TYR-VAL-ALA-ASP-CHO
ACETYL-YVAD ALDEHYDE L-709,049, SYNTHETI C
ICE (CASPASE I) INHIBITOR I
Caspase 1 (ICE) Inhibitor 2
N-acetyl-Tyr-Val-Ala-aspartinal
Acetyl-tyrosyl-valyl-alanyl-aspartal
N-Acetyl-Tyr-Val-Ala-Asp-al
(S)-N-Acetyl-L-tyrosyl-L-valyl-N-(2-carboxy-1-formylethyl)-L-alaninamide
Acetyl-tyrosyl-valyl-alanyl-aspartinal
Acetyl-Tyr-Val-Ala-Asp-cho
Ac-YVAD-CHO, L-709049
L-Alaninamide, N-acetyl-L-tyrosyl-L-valyl-N-[(1S)-2-carboxy-1-formylethyl]-
AC-YVAD-CHO USP/EP/BP
Ac-YVAD-CHO (N-Ac-Tyr-Val-Ala-Asp-CHO)
N-Ac-Tyr-Val-Ala-Asp-Aldehyde
143313-51-3
C23H32N4O8
Biochemicals and Reagents
BioChemical
Amino Acids and Peptides
Other Peptides
Peptides
Caspases/Apoptosis
peptide
Pepetides
peptides