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Pemetrexed

Pemetrexed Structure
CAS No.
137281-23-3
Chemical Name:
Pemetrexed
Synonyms
PEMETREXED;(S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid;Premetred;PEMETREXED;Pemetrexedum;Pemetrexed99%;Pemetrexedaci;(R)-Pemetrexed;PeMetrexed-15C5;PeMetrexed-13C5
CBNumber:
CB4170583
Molecular Formula:
C20H21N5O6
Molecular Weight:
427.41
MOL File:
137281-23-3.mol
Modify Date:
2024/1/22 14:59:33
Request For Quotation

Pemetrexed Properties

Density 1.59±0.1 g/cm3(Predicted)
storage temp. 2-8°C(protect from light)
solubility slightly sol. in Methanol
form powder to crystal
pka 3.58±0.10(Predicted)
color White to Blue
Merck 14,7077
CAS DataBase Reference 137281-23-3(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
RTECS  LZ9950100
HS Code  2933.99.9701

Pemetrexed price More Price(2)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemicals (India) P2288 Pemetrexed 137281-23-3 250MG ₹4800 2022-05-26 Buy
TCI Chemicals (India) P2288 Pemetrexed 137281-23-3 1G ₹10100 2022-05-26 Buy
Product number Packaging Price Buy
P2288 250MG ₹4800 Buy
P2288 1G ₹10100 Buy

Pemetrexed Chemical Properties,Uses,Production

Chemical Properties

N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt is Off-White Solid

Uses

Pemetrexed is used in the treatment of malignant pleural mesothelioma (MPM) and erectile dysfunction therapy.

Definition

ChEBI: Pemetrexed is an N-acylglutamic acid in which the N-acyl group is specified as 4-[2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl. Inhibits thymidylate synthase (TS), 421 dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT). It has a role as an antineoplastic agent, an antimetabolite, an EC 2.1.1.45 (thymidylate synthase) inhibitor, an EC 1.5.1.3 (dihydrofolate reductase) inhibitor and an EC 2.1.2.2 (phosphoribosylglycinamide formyltransferase) inhibitor. It is a pyrrolopyrimidine and a N-acyl-L-glutamic acid. It is a conjugate acid of a pemetrexed(2-).

Side effects

The most common side effects for pemetrexed include fatigue, nausea, vomiting, anorexia, mucositis, myelosuppression ± infection, bleeding, rash, diarrhea and ↑ LFTs.
Severe myelosuppression is often dose-limiting for pemetrexed. Sepsis, in some cases fatal, have occurred in approximately 1% of patients in clinical trials. Prophylactic folic acid and intramuscular vitamin B12 supplements are necessary to reduce hematologic or non-hematologic toxicities.
Pemetrexed may cause serious and in some cases fatal dermatologic toxicities. Rarely, StevensJohnson syndrome and toxic epidermal necrolysis have been reported.

Mode of action

Pemetrexed is a pyrrolopyrimidine antifolate that exerts its antineoplastic activity by inhibiting thymidylate synthase (TS), glycinamide ribonucleotide formyltransferase (GARFT) and dihydrofolate reductase (DHFR), which are involved in folate metabolism and DNA synthesis, resulting in inhibition of purine and thymidine nucleotide synthesis.

Pemetrexed Preparation Products And Raw materials

Raw materials

Preparation Products

Pemetrexed Suppliers

Global( 360)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Varanous Labs Pvt Ltd +91-7036248882 +91-7036248882 Hyderabad, India 1541 58 Inquiry
Dodhia Group +91-9619867345 +91-9619867345 Mumbai, India 129 58 Inquiry
HRV Global Life Sciences +91-9820219686 +91-9820219686 Telangana, India 379 58 Inquiry
Shreyaa Medilife Private Limited +91-6354474696 +91-9879513108 Ahmedabad, India 67 58 Inquiry
Gland Chemicals Pvt Ltd +91-9492733833 +91-9346729196 Telangana, India 16 58 Inquiry
Kekule Pharma Limited +919849798889 Hyderabad, India 59 58 Inquiry
Raising Sun Pharma +91-9399941155 +91-9399941155 Telangana, India 127 58 Inquiry
Laurus Labs Ltd +91-4066594333 +91-4039804333 Telangana, India 50 58 Inquiry
Shivalik Rasayan Ltd +91-1147589500 +91-9811043611 New Delhi, India 12 58 Inquiry
Akums Lifesciences Ltd +91-1147511000 +91-1147511000 New Delhi, India 38 58 Inquiry
Supplier Advantage
Varanous Labs Pvt Ltd 58
Dodhia Group 58
HRV Global Life Sciences 58
Shreyaa Medilife Private Limited 58
Gland Chemicals Pvt Ltd 58
Kekule Pharma Limited 58
Raising Sun Pharma 58
Laurus Labs Ltd 58
Shivalik Rasayan Ltd 58
Akums Lifesciences Ltd 58

Pemetrexed Spectrum

Pemetrexed(137281-23-3)1HNMR

137281-23-3(Pemetrexed)Related Search:

Pemetrexed Disodium Pemetrexed disodium hemipentahydrate Pemetrexed Pyrrolo[2,3-d]pyrimidin-4-ol 2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine
CHEMBRDG-BB 9071517 2-AMINO-5-METHYL-3,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-ONE CHEMBRDG-BB 9071952 CHEMBRDG-BB 9071469
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PeMetrexed-13C5 PeMetrexed-15C5 N-[4-[2-(2-aMino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]L-GlutaMic acid (PeMetrexed acid) N-[4-[2-(2-AMino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl]benzoyl]-L-glutaMic acid (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedi N-[4-[2-(2-Amino-4,7 (2R)-2-{[4-(2-{2-aMino-4-oxo-1H,4H,7H-pyrrolo[2,3-d]pyriMidin-5-yl}ethyl)phenyl]forMaMido}pentanedioic acid N-(4- 2-(2-AMino-4,7-Dihydro-4-oxo-1H-pyrrol... PeMetrexed disodiuM INT-6 (S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid The sour sour of the United States Pemetrexed Hydrate Pemetrexed - Labeled 15N,13C5 (R)-Pemetrexed (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-1H-pyrrolo-[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentan PEMETREXED ACID PEMETREXED N-(4-[2-(2-Amino-4,7-Dihydro-4-oxo-1H-pyrrolo)[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-Gluamic Acid Pemetrexed99% L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]- N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt PEFLOXACINMESYLATE Premetred disodium Pemetrexedum Premetred PemetrexedHydrate> (S)-2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrroL )benzamido)pentanedioic acid 3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid disodium salt N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidi... PemetrexedQ: What is Pemetrexed Q: What is the CAS Number of Pemetrexed Q: What is the storage condition of Pemetrexed Q: What are the applications of Pemetrexed PEMETREXED (S)-2-(4-(2-(2-AMino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyriMidin-5-yl)ethyl)benzaMido)pentanedioic acid Pemetrexedaci 137281-23-3 C20H21N5O6xH2O Anti-cancer & immunity API CIALIS