BENPROPERINE
- CAS No.
- 2156-27-6
- Chemical Name:
- BENPROPERINE
- Synonyms
- pirexyl;Benproperin;BRN 1258822;BRN-1258822;BENPROPERINE;Bemproperina;Benproperinum;Benproperine Monomer;BENPROPERINE USP/EP/BP;1-(2-Benzylphenoxy)-2-piperidinopropane
- CBNumber:
- CB4187277
- Molecular Formula:
- C21H27NO
- Molecular Weight:
- 309.45
- MOL File:
- 2156-27-6.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/4 17:34:35
BENPROPERINE Chemical Properties,Uses,Production
Originator
Tussafug,Medipharm,Switz.
Manufacturing Process
A mixture of 26.1 g of o-benzylphenoxy-β-chloropropane and 17 g of piperidine is refluxed over a period of 32 hours until the temperature is about 124°C and a nearly solid mixture is formed due to the precipitation of a salt. The mixture is then refluxed over a period of 48 hours at about 160°C and the reaction product obtained is cooled and dissolved in methanol. The solution is concentrated under reduced pressure to yield an oil which is added to 200 ml 3N hydrochloric acid whereupon the mixture is shaken with ether, 3 x 100 ml, until the aqueous phase is clear. The ether solution is washed with water, 3 x 50 ml, and the water present in the combined aqueous phase and water used for washing is evaporated under reduced pressure methanol being added three times when the residue appears to be dry. The impure hydrochloride of o-benzylphenoxy-β-N-piperidinopropane, 41 g, obtained is dissolved in 100 ml water and 100 ml 30% aqueous sodium hydroxide solution are added, whereupon precipitated oil is extracted with ether, 1 x 100 and 2 x 50 ml. The ether solution is washed with water, 4 x 50 ml, dried with magnesium sulfate and the ether is removed under reduced pressure. The residue, 25.2 g, is distilled under reduced pressure and the main fraction, 23.2 g, BP 159°-161°C/0.2 mm.
Therapeutic Function
Antitussive
BENPROPERINE Preparation Products And Raw materials
BENPROPERINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29900 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | 18192627656 | China | 1393 | 58 | Inquiry |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | China | 34571 | 58 | Inquiry |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | China | 26114 | 58 | Inquiry |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | China | 52861 | 58 | Inquiry |
| changzhou huayang technology co., ltd | +8615250961469 | China | 9821 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 | United States | 19973 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| DONBOO AMINO ACID COMPANY | +8613063595538 | China | 9365 | 58 | Inquiry |
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