ENDRIN
- CAS No.
- 72-20-8
- Chemical Name:
- ENDRIN
- Synonyms
- Endrine;Nendrin;1,2,3,4,10,10-hexachloro-6,7-epox;1,2,3,4,10,10-Hexachloro-6,7-epoxy-1,4,4a,5,6,7,8,8a-octahydro-endo-1,4-endo-5,8-dimethanonaphthalene;en57;EN 57;Endrex;oms197;sd3419;ENDRIN
- CBNumber:
- CB4208921
- Molecular Formula:
- C12H8Cl6O
- Molecular Weight:
- 380.91
- MOL File:
- 72-20-8.mol
- Modify Date:
- 2024/3/14 15:18:26
| Melting point | 245℃ (Decomposition) |
|---|---|
| Boiling point | 496.11°C (rough estimate) |
| Density | 1.7 g/cm3 |
| vapor pressure | 2 x 10-7 mmHg at 25 °C (ACGIH, 1986) |
| refractive index | 1.5550 (estimate) |
| Flash point | 11 °C |
| storage temp. | APPROX 4°C |
| Water Solubility | 0.25mg/L(25 ºC) |
| Merck | 13,3612 |
| Henry's Law Constant | 1.78 at 5 °C, 2.96 at 15 °C, 4.54 at 20 °C, 5.63 at 25 °C, 8.68 at 35 °C:in 3% NaCl solution: 5.13 at 5 °C, 9.47 at 15 °C, 18.8 at 25 °C, 19.7 at 35 °C (gas stripping-GC, Cetin et al., 2006) |
| Exposure limits | NIOSH REL: TWA 0.1 mg/m3, IDLH 2 mg/m3; OSHA PEL: TWA 0.1 mg/m3; ACGIH TLV: TWA 0.1 mg/m3. |
| Stability | Stable. Incompatible with strong acids, strong oxidizers. Corrodes some metals. |
| IARC | 3 (Vol. 5, Sup 7) 1987 |
| EPA Substance Registry System | Endrin (72-20-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310-H410 | |||||||||
| Precautionary statements | P262-P264-P273-P280-P301+P310-P302+P352+P310 | |||||||||
| Hazard Codes | T+,N,T,F,Xi,Xn | |||||||||
| Risk Statements | 24-28-50/53-39/23/24/25-23/24/25-11-67-65-38 | |||||||||
| Safety Statements | 22-36/37-45-60-61-16-7-33-62 | |||||||||
| RIDADR | 2761 | |||||||||
| OEB | D | |||||||||
| OEL | TWA: 0.1 mg/m3 [skin] | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | IO1575000 | |||||||||
| HazardClass | 6.1(a) | |||||||||
| PackingGroup | I | |||||||||
| HS Code | 29109000 | |||||||||
| Toxicity | LD50 in female, male rats (mg/kg): 7.5, 18 orally (Gaines) | |||||||||
| IDLA | 2 mg/m3 | |||||||||
| NFPA 704 |
|
ENDRIN Chemical Properties,Uses,Production
Chemical Properties
Endrin is an organochlorine compound. Endrin appears as a white or beige crystalline solid and is stable. It is incompatible with strong acids and strong oxidisers and corrodes some metals. Endrin decomposes on heating above 245°C, producing hydrogen chloride and phosgene. Endrin is incompatible with strong oxidisers, strong acids, and parathion and emits hydrogen chloride and phosgene when heated or burned.
Physical properties
White, crystalline solid when pure; light tan color with faint chemical odor for technical grades. Odor threshold concentrations in air ranged from 18 to 41 ppb (quoted, Keith and Walters, 1992). Robeck et al. (1965) reported an odor threshold concentration of 9 ppb.
Uses
All uses of endrin in the United States were canceled by the manufacturer in 1986; formerly used as an insecticide, avicide, and rodenticide
Definition
A stereoisomer of dieldrin which is the endo, exo isomer.
General Description
ENDRIN is a white crystalline, odorless solid dissolved in a liquid carrier. ENDRIN is water emulsifiable. ENDRIN is toxic by inhalation, skin absorption, and/or ingestion. When heated or burned ENDRIN may emit toxic hydrogen chloride and phosgene. ENDRIN is used as a pesticide.
Reactivity Profile
While a mixture of parathion and ENDRIN was being blended into a petroleum solvent, an exothermic reaction occurred that caused some of the petroleum solvent to vaporize. The solvent-vapor-air mixture exploded. The mechanical agitation possibly initiated the exothermic reaction, Doyle(1973). Toxic hydrogen chloride and phosgene may be generated when solution burns. Avoid strong oxidizers, strong acids and parathion. [EPA, 1998].
Hazard
Toxic by inhalation and skin absorption, use may be restricted. Headache, liver damage, and central nervous system impairment. Questionable carcinogen.
Health Hazard
ENDRIN is extremely toxic. It is rapidly absorbed through the skin. Symptoms appear between 20 minutes and 12 hours after exposure. There is evidence that ENDRIN may cause chromosomal damage. Doses of 1 mg/kg can cause symptoms. It is a suspected carcinogen. Also, it is a central nervous system depressant and hepatotoxin. Pregnant women are considered to be at special risk.
Fire Hazard
Toxic hydrogen chloride and phosgene may be generated when solution burns. Avoid strong oxidizers, strong acids and parathion.
Agricultural Uses
Insecticide, Avicide: Not approved for use in EU countries. A U.S. EPA restricted Use Pesticide (RUP). It is a persistent and acutely toxic insecticide. Endrin is an insecticide which has been used to control insects, rodents, and birds, mainly on field crops such as cotton, maize, sugarcane, rice, cereals, ornamentals, and other crops. It has also been used for grasshoppers in non-cropland and to control voles and mice in orchards. Once widely used in the U.S., most uses were canceled in 1980 and it has not been produced nor sold in the U.S. since 1986. It is not easily dissolved in water and can remain in the soil for more than 14 years.
Trade name
COMPOUND 269®; EN 57®; ENDREX®; ENDRICOL®; ENDRIN CHLORINATED HYDROCARBON INSECTICIDE®; HEXADRIN®; MENDRIN®; NENDRIN®; OKTANEX®
Safety Profile
Poison by ingestion, skin contact, and intravenous routes. Experimental teratogenic and reproductive effects. Questionable carcinogen. Mutation data reported. A central nervous system stimulant. Highly toxic to birds, fish, and humans. Many cases of fatal poisoning have been attributed to it. Does not accumulate in human tissue. In humans, ingestion of 1 mg/kg has caused symptoms. A dangerous fire hazard. Mixtures with parahon dlssolve very exothermically in petroleum solvents and may cause an air-vapor explosion. See also ALDFUN.
Potential Exposure
A potential danger to those involved in manufacture, formulation and field application of this insecticide, avicide, and rodenticide. Pesticide not in use; TRI and/ or IUR indicates importers or manufacturers are unlikely.
Shipping
UN2761 Organochlorine pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials
Incompatibilities
Incompatible with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids (forms explosive vapors), oxoacids, epoxides, and parathion. Slightly corrosive to metal
Waste Disposal
A disposal procedure recommended by the manufacturer consists of absorption, if necessary, and burial at least 18 in deep; preferably in sandy soil in a flat or depressed location away from wells, livestock, children, wildlife, etc. Incineration is the recommended method. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
Precautions
Students and occupational workers should be careful during handling of endrin. Workers should not wash away the chemical waste into the sewer, but sweep spilled chemical substance into sealable containers. Workers should use extra personal protection, face shield and eye protection, a chemical protection suit, and self-contained breathing apparatus. Exposures to endrin cause effects on the CNS leading
ENDRIN Preparation Products And Raw materials
Raw materials
Preparation Products
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