ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine dihydrochloride

N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine dihydrochloride

CAS No.: 1260590-51-9

Chemical Name:: N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine dihydrochloride

Synonyms: N-Methyl-N-((3R,4R);-4-methylpiperidin-3-yl);N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin;N-METHYL-N-((3R,4R)-4-METHYLPIPERIDIN-3-YL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE HCL;N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 2HCl;N-Methyl-N-[(3R,4R)-4-methyl-3-piperidyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine Hydrochloride;N-Methyl-N-[(3R,4R)-4-methyl-3-piperidyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine x hydrochloride;N-Methyl-N-[(3R,4R)-4-methyl-3-piperidinyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride;N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine dihydrochloride;N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-amine dihydrochloride (N-1 HCl)

CBNumber:: CB42718116

Molecular Formula:: C13H20ClN5

Molecular Weight:: 281.79

MOL File:: 1260590-51-9.mol

Modify Date:: 2023/6/10 9:26:26

Request For Quotation

N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine dihydrochloride Properties

Melting point	>225°C (dec.)
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Aqueous Acid (Slightly, Sonicated), Aqueous Base (Slightly), Water (Slightly)
form	Solid
color	White to Off-White

N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine dihydrochloride Chemical Properties,Uses,Production

Synthesis

Add TFTB-1, sodium hydroxide, ethanol and water to a 20L reaction flask, heat to 85 ° C, and keep the reaction for 3 hours. At the end of the reaction, vacuum distillation at 80-90 ° C until no liquid flows out. Add purified water and continue stirring. The mixture was cooled to room temperature, extracted with dichloromethane, and the aqueous layer was extracted with methylene chloride. The organic layer was combined, and the organic layer was washed with purified water. Filtration, evaporation of the filtrate, addition of acetone, reflux for 30 min, cooling to 20 ° C, filtration, filter cake into a dry box, drying at 60 ° C ± 5 ° C for 4 h, to obtain a white solid, that is, TFTB-2, yield 86%.

Application

N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine is a substance used in the identification of related substances in the degradation products of tofacitinib citrate using LC-MS technique for process monitoring and quality assurance. A reagent for the synthesis of Tofacitinib (CP-690,550), a Janus tyrosine kinase (JAK3) specific inhibitor.

N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine dihydrochloride Suppliers

Global( 77)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	China	29798	60	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29899	58	Inquiry
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	China	39916	58	Inquiry
Shanghai Yingrui Biopharma Co.,Ltd	21-33585366	CHINA	1320	58	Inquiry
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	China	5738	58	Inquiry
Chengdu Aslee Biopharmaceuticals, Inc.	28-85305008	CHINA	964	58	Inquiry
Senova Technology Co. Ltd.	+86-0755-86703119 +8618503098836	China	351	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
Capot Chemical Co.,Ltd.	60
career henan chemical co	58
Chongqing Chemdad Co., Ltd	58
Shanghai Yingrui Biopharma Co.,Ltd	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58
Chengdu Aslee Biopharmaceuticals, Inc.	58
Senova Technology Co. Ltd.	58

1260590-51-9(N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine dihydrochloride)Related Search:

N-Methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine dihydrochloride N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine 2-Isopropyl-4-[(N-methylamino)methyl]thiazole hydrochloride Tofacitinib citrate 3-bis(4-Methylbenzoyloxy)succinate)

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

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N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine dihydrochloride N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-amine dihydrochloride (N-1 HCl) N-Methyl-N-[(3R,4R)-4-methyl-3-piperidyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine x hydrochloride -4-methylpiperidin-3-yl) N-Methyl-N-((3R,4R) N-METHYL-N-((3R,4R)-4-METHYLPIPERIDIN-3-YL)-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE HCL N-Methyl-N-[(3R,4R)-4-methyl-3-piperidyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine Hydrochloride N-Methyl-N-[(3R,4R)-4-methyl-3-piperidinyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine hydrochloride N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin N-Methyl-N-((3R,4R)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 2HCl 1260590-51-9 C13H20ClN5