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ChemicalBook > Product Catalog >Pharmaceutical intermediates >Bulk Drug Intermediates >(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Structure
CAS No.
1062580-52-2
Chemical Name:
(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride
Synonyms
(3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride;TOF30;Tofacitinib-1;Tofatinib Impurity 5;Tofacitinib interMediate A;Tofacitinib intermediate 3;piperidin-3-amine dihydrochL;Tofacitinib Impurity 123 DiHCl;Azilsartan medoxomil impurity351;Tofacitinib Impurity 5 Dihydrochloride
CBNumber:
CB21011155
Molecular Formula:
C14H23ClN2
Molecular Weight:
254.8
MOL File:
Mol file
Modify Date:
2024/5/18 8:51:57
Request For Quotation

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Properties

Melting point 249～251℃
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Aqueous Acid (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly)
form Solid
color White to Off-White
InChI InChI=1/C14H22N2.ClH/c1-12-8-9-16(11-14(12)15-2)10-13-6-4-3-5-7-13;/h3-7,12,14-15H,8-11H2,1-2H3;1H/t12-,14+;/s3
InChIKey FVRZQLQXDPJADE-WLZBWWFYNA-N
SMILES C(C1C=CC=CC=1)N1CC[C@@H](C)[C@@H](NC)C1.Cl |&1:10,12,r|

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P264-P270-P301+P312-P330-P501
HazardClass  IRRITANT
HS Code  2933399990

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Chemical Properties,Uses,Production

Uses

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production processes.

Uses

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride is a related compound of Tofacitinib (T528000). (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride can be used to prepare janus kinase 1 selective inhibitor.

Synthesis

Synthesis_1062580-52-2
TiCl4(0.2g, 1mmol) and NEt3(0.15 g, 1.5 mmol) were added to toluene, and then add 1-benzyl-4-methyl-3-ketone piperidine (20.3 g, 100 mmol) at 35 ℃. The methylamine solution is added to the reaction solution (9.32 g, 120 mmol) and reaction for 4 h, followed by adding NaBH (OAC) 3 (0.32 g, 1.5 mmol) and glacial acetic acid 2 ml. After the reaction is complete, add saturated salt water to wash the reaction mixture. (3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride was obtained after further purification.

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Preparation Products And Raw materials

Raw materials

(3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE 1-benzyl-4-methylpiperidin-3-one (1-Benzyl-4-Methyl-1,2,5,6-tetrahydropyridin-3-yl)carbaMic acid Methyl ester Methanamine Acetate
3-Amino-4-methylpyridine
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Preparation Products

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Suppliers

Global( 357)Suppliers
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Bulat Pharmaceutical Pvt Ltd +91-8448085659 +91-8448085660 Haryana, India 123 58 Inquiry
Shree Jaya Laboratories Pvt. Ltd. +91-91-40-29881167 +91-9966167167 Hyderabad, India 78 58 Inquiry
VGS SYNTHESIS PRIVATE LIMITED +91-9866975588 +91-9866975588 Hyderabad, India 1818 58 Inquiry
Vidgas science and technologies Pvt Ltd +91-9030019844 +91-9030019844 Telangana, India 76 58 Inquiry
Synergene Active Ingredients Pvt. Ltd. +91-04023700774 +91-04023700774 Telangana, India 96 58 Inquiry
Actis Generics Pvt Ltd +91-9949094333 +91-9866922779 AndhraPradesh, India 44 58 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
A.J Chemicals 91-9810153283 New Delhi, India 6124 58 Inquiry
Changsha Junyu Chemexpress.co., Ltd +86-13723890100 China 134 58 Inquiry
Shanghai Boc Chemical Co., Ltd. 021-34975602; +8618721111801 China 138 58 Inquiry
Supplier Advantage
Bulat Pharmaceutical Pvt Ltd 58
Shree Jaya Laboratories Pvt. Ltd. 58
VGS SYNTHESIS PRIVATE LIMITED 58
Vidgas science and technologies Pvt Ltd 58
Synergene Active Ingredients Pvt. Ltd. 58
Actis Generics Pvt Ltd 58
CLEARSYNTH LABS LTD. 58
A.J Chemicals 58
Changsha Junyu Chemexpress.co., Ltd 58
Shanghai Boc Chemical Co., Ltd. 58

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride Spectrum

(3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride(1062580-52-2)1HNMR

1062580-52-2((3R,4R)-1-benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride)Related Search:

(1-Benzyl-4-Methyl-1,2,5,6-tetrahydropyridin-3-yl)carbaMic acid Methyl ester Methyl (1-benzyl-4-Methylpiperidin-3-yl)carbaMate 13-Deoxyepirubicin 3-((3R,4S)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile 3-METHOXYCARBONYLAMINO-4-METHYLPYRIDINE
1-[2-(2-methoxyphenoxy)ethylamino]-3-(9-methylcarbazol-4-yl)oxypropan-2-ol:hydrochloride Methyl (4-Methylpiperidin-3-yl)carbaMate 3-((3S,4R)-4-Methyl-3-(Methyl(7H-pyrrolo[2,3-d]pyriMidin-4-yl)aMino)piperidin-1-yl)-3-oxopropanenitrile 3-PiperidinaMine, 1-acetyl-N,4-diMethyl-N-1H-pyrrolo[2,3-d]pyriMidin-4-yl-, (3R,4R)- (9CI) 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
N-((3R,4R)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (3R,4R)-1-Benzyl-N,4-dimethylpiperidin-3-amine 2,4-DICHLORO-7H-PYRROLO2,3-DPYRIMIDINE 7H-Pyrrolo[2,3-d]pyriMidin-4-aMine, N-Methyl-N-[(3R,4R)-4-Methyl-1-(phenylMethyl)-3-piperidinyl]-7-[(4-Met hylphenyl)sulfonyl]-
4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE Tofacitinib citrate 3-bis(4-Methylbenzoyloxy)succinate)
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CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE) cis-1-Benzyl-N,4-dimethylpiperidin-3-amine dihydrochloride cis-1-Benzyl-4-methyl-3-(methylamino)piperidine dihydrochloride 95+% cis-1-Benzyl-N3,4-dimethylpiperidin-3-amine dihydrochloride (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORIDE (3R,4R)-1-benzyl-N,4-diMethylpiperidin-3-aMine BIS-(HYDROCHLORIDE) 3-PiperidinaMine, N,4-diMethyl-1-(phenylMethyl)-, hydrochloride (1:2), (3R,4R)- (3R,4R)-N,4-DiMethyl-1-(phenylMethyl)-3-piperidi (3R,4R)- Cis-1-benzyl-4-Methyl-3-(MethylaMino)piperidine Tofacitinib interMediate A (3R,4R)- cis-1-Benzyl-4-Methyl-3-(MethylaMino)piperidine dihydrochloride (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE DIHYDROCHLORID 3-Piperidinamine, N,4-dimethyl-1-(phenylmethyl)-, dihydrochloride, (3R,4R)- Tofacitinib intermediate 3 (3R,4R)-(1-Benzyl-4-methyl-piperidin-3-yl)-methyl-amine dihydrochloride Azilsartan medoxomil impurity351 (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydro... Tofacitinib Impurity 5 Dihydrochloride N-((3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINE 2HCL (3R,4R)-1-BENZYL-N,4-DIMETHYLPIPERIDIN-3-AMINEDITYDROCHLORIDE Cis-n-benzyl-3-methylamino-4-methyl-piperidine bis-(, HCl ) (3R,?4R)?-N,?4-?Dimethyl-?1-?(phenylmethyl)?-3-?piperidinamine Dihydrochloride piperidin-3-amine dihydrochL (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine, hydrochloride (1:2) Cis 1-benzyl-4-methyl-3-methylamino-piperidine hydrochloride Tofacitinib-1 TOF30 (3R,4R)-1-Benzyl-3-(methylamino)-4-methylpiperidine Dihydrochloride (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine HCl (3R,4R)-N,4-Dimethyl-1-(phenylmethyl)-3-piperidinamine hydrochloride (3R,4R)-N, 4-dimethyl-1 -(phenylmethyl) -3-piperidamine hydrochloride Tofatinib Impurity 5 (3R,4R)-N,4-Dimethy1-(phenylmethyl)-3-piperidinamine hydrochloride CIS-N-BENZYL-3-METHYLAMINO-4-METHYL-PIPERIDINE BIS-(HYDROCHLORIDE) Tofacitinib （Int.） Tofacitinib Impurity 123 DiHCl (3R,4R)-N,4-Dimethyl-1-(benzyl)-3-piperidinamine 2HCl (3R,4R)-1-Benzyl-N,4-dimethyl-3-piperidinamine dihydrochloride 1062580-52-2 C14H22N22HCl 1