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ChemicalBook > Product Catalog >Biochemical Engineering >Nucleoside drugs >Nucleotides and their analogs >4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Structure
CAS No.
3680-69-1
Chemical Name:
4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
Synonyms
4-CHLOROPYRROLO[2,3-D]PYRIMIDINE;6-CHLORO-7-DEAZAPURINE;6-CHLORO-7-DEAZAPURINE 4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLORO-1H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLOROPYRROLO[2,3-D]PYRIMIDINE 6-CHLORO-7-DEAZAPURIN;Nsc 64952;Brn 0607871;Tofacitinib-6;oro-7-deazapurine;Tofacitib impurity Q;Chloro-7-deazapurine;Tofatinib Impurity 6
CBNumber:
CB8742621
Molecular Formula:
C6H4ClN3
Molecular Weight:
153.57
MOL File:
3680-69-1.mol
MSDS File:
SDS
Modify Date:
2024/5/24 18:18:52
Request For Quotation

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Properties

Melting point 188-194 °C
Boiling point 289.2±50.0 °C(Predicted)
Density 1.61±0.1 g/cm3(Predicted)
vapor pressure 0Pa at 25℃
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility Soluble in DMSO, ethyl acetate and methanol.
form Crystalline Powder
pka 11.42±0.20(Predicted)
color White to tan
InChI InChI=1S/C6H4ClN3/c7-5-4-1-2-8-6(4)10-3-9-5/h1-3H,(H,8,9,10)
InChIKey BPTCCCTWWAUJRK-UHFFFAOYSA-N
SMILES C1=NC(Cl)=C2C=CNC2=N1
LogP 0.858 at 30℃
CAS DataBase Reference 3680-69-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301
Precautionary statements  P301+P310
Hazard Codes  Xi,T,Xn
Risk Statements  36/37/38-25-20/21/22
Safety Statements  26-37-45-36
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  UY9360000
TSCA  No
HazardClass  IRRITANT
PackingGroup  Ⅲ
HS Code  29335990
NFPA 704
1
3 0

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine price More Price(3)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 699489 6-Chloro-7-deazapurine 97% 3680-69-1 1G ₹14483.85 2022-06-14 Buy
TCI Chemicals (India) C2306 6-Chloro-7-deazapurine min. 98.0 % 3680-69-1 1G ₹5700 2022-05-26 Buy
TCI Chemicals (India) C2306 6-Chloro-7-deazapurine min. 98.0 % 3680-69-1 5G ₹16800 2022-05-26 Buy
Product number Packaging Price Buy
699489 1G ₹14483.85 Buy
C2306 1G ₹5700 Buy
C2306 5G ₹16800 Buy

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Chemical Properties,Uses,Production

Chemical Properties

Lightbrown to brown crystalline powder

Uses

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine is used in the manufacture of Tofacitinib citrate.

Synthesis

The preparation process of pyrimidine includes the first α -alkylation reaction between diethyl malonate and allyl bromide, and the subsequent cyclization reaction with amidine to obtain a six-membered ring of bislactam. The chlorination of carbonyl with phosphorus oxychloride to obtain dichloro pyrimidine ring, followed by the oxidation of the terminal double bond with potassium osmate hydrate and sodium periodate to obtain the aldehyde group. The final reaction with ammonia water to produce SNAr/cyclization reaction, a five-step reaction, total yield of 45.8% to obtain 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine. 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine

4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Pyrrolo[2,3-d]pyrimidin-4-ol Bromoacetaldehyde diethyl acetal Potassium carbonate Sodium Phosphorus oxychloride
Sodium iodide RANEY NICKEL Ammonium chloride Ethyl cyanoacetate Thiourea
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Preparation Products

7H-Pyrrolo[2,3-d]pyrimidine 5-iodo-7-Methyl-7H-pyrrolo[2,3-d]pyriMidin-4-aMine 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile (4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-7-yl)methyl pivalate 4-chloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine
5-IODOTUBERCIDIN
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4-Chloro-7H-pyrrolo[2,3-d]pyrimidine Suppliers

Global( 924)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED +919966658228 Hyderabad, India 486 58 Inquiry
EPOCH LABS +91-7702174901 +91-9515109812 Hyderabad, India 68 58 Inquiry
A.R. LIFE SCIENCES PVT. LTD. +91-914040267679 +91-8519993257 Hyderabad, India 100 58 Inquiry
GOALSY PHARMA +91-8247562464 +91-9885583385 Hyderabad, India 479 58 Inquiry
REAX CHEMICALS +91-9347443900 +91-9347443900 Hyderabad, India 169 58 Inquiry
Bulat Pharmaceutical Pvt Ltd +91-8448085659 +91-8448085660 Haryana, India 123 58 Inquiry
Credas Labs Pvt Ltd +91 9133918031 Hyderabad, India 119 58 Inquiry
PRODIGIOUS LIFE SCIENCES +91-9177472555 +91-9177472555 Hyderabad, India 236 58 Inquiry
TYNDAL LABS PVT LTD +91-8008166674 +91-8008166674 AndhraPradesh, India 95 58 Inquiry
VGS SYNTHESIS PRIVATE LIMITED +91-9866975588 +91-9866975588 Hyderabad, India 1818 58 Inquiry
Supplier Advantage
ALTRAKEM PHARMA LIFE SCIENCES PRIVATE LIMITED 58
EPOCH LABS 58
A.R. LIFE SCIENCES PVT. LTD. 58
GOALSY PHARMA 58
REAX CHEMICALS 58
Bulat Pharmaceutical Pvt Ltd 58
Credas Labs Pvt Ltd 58
PRODIGIOUS LIFE SCIENCES 58
TYNDAL LABS PVT LTD 58
VGS SYNTHESIS PRIVATE LIMITED 58

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4-chloro-7,7a-dihydro-4aH-pyrrolo[2,3-d]pyrimidine 4-chloro-7H-pyrrolo[2,3-d]pyrimidine(SALTDATA: FREE) 4-Chloropyrrolo[2,3-d]pyriMidine 6-Chloro-7-deazapurine 7H-pyrrolo[2,3-d]pyriMidine, 6-Chloro-7-deazapurine 4-chloro-7H-pyrollo[2,3d]pyriMidine 4-Methyl-1,3-thiazole-2,5-diaMine Tofacitinib interMediate C 6-Chloro-7-deazapurine ,98% 4-chloro-7H-pyrrolo[2,3-d]pyrimidine/6-Chloro-7-deazapurine Nsc 64952 Brn 0607871 7H-pyrrolo[2,3-d]pyrimidine, 4-chloro- Tofacitinib Impurity Q 4-Chloropyrro[2,3-d] pyriMidine 4-Chloro-(2,3-d)pyrimidine 4-chloro-7H-pyrrolo[3,2-e]pyrimidine Tofacitinib int-2 4-Chloropyrrolo[2,3-d]pyrimidine 4-Chloropyrrolo[2,3-d]pyrimidine 4-Chloro-1H-pyrrolo[2,3-d]pyrimidine 3-d)pyrimidine,4-chloro-7h-pyrrolo( 4-METHYL-2,5-DIAMINETHIAZOLE 6-Chloro-7-deazapurine, 4-Chloro-1H-pyrrolo[2,3-d]pyrimidine 6-CHLORO-7-DEAZAPURINE 98.5% 4-CHLORO-4H-PYRROLO[2,3-D]PYRIMIDINE 6-Chloro-7-deazapurin 4-Chloro-1H-pyrrolo[2,3-d]pyrimidine4-Chloropyrrolo[2,3-d]pyrimidine 4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLORO-1H-PYRROLO(2,3-D)PYRIMIDINE Tofacitib impurity Q oro-7-deazapurine 6-Chloro-7-deazapurine> Chloro-7-deazapurine Tofacitinib-6 Tofacitinib citrate intermediate 6-CHLORO-7-DEAZAPURINE 4-CHLORO-7 4-chloropyrrolopyrimidine 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine(Cas number：3680-69-1) 4-Chloro-7H-pyrrolo[2,3-d]pyridine 8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta 4-Chloro-7H-pyrrolo[2,3-d]pyrimidine USP/EP/BP -Chloro-7H-pyrrolo[2,3-d]pyrimidine -Chloropyrrolo(2,3-d)pyrimidine Azilsartan medoxomil impurity348 4-Chloro-1H-pyrrolo(2,3-d)pyrimidine(3680-69-1) 4-Chloro-7H-pyrrolo[2,3-d]py 6-CHLORO-7-DEAZAPURINE 4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLORO-1H-PYRROLO[2,3-D]PYRIMIDINE 4-CHLOROPYRROLO[2,3-D]PYRIMIDINE 6-CHLORO-7-DEAZAPURIN 6-CHLORO-7-DEAZAPURINE 4-CHLOROPYRROLO[2,3-D]PYRIMIDINE 4-chloropyrropyrimidine Tofatinib Impurity 6 4-Chloro-7H-pyrrolo4-Chloro-7H-pyrrolo[2,3-d]pyrimidine[2,3-d]pyrimidine Baricitinib intermediate 3 4-Chloropyrrolidone pyrimidine 3680-69-1 Fused Ring Systems Heterocyclic Building Blocks Heterocycle-Pyrimidine series Baricitinib Ruxolitinib